Results 41 to 50 of about 368,090 (311)

Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis

Journal for ImmunoTherapy of Cancer, 2021
Background Neutrophils-linked premetastatic niche plays a key role in tumor metastasis, but not much is known about the heterogeneity and diverse role of neutrophils in niche formation.
Ke Wang, Jian Huang, Zhen Wang, Haijun Wang, Jun Pan, Jun Yan, Zhigang Zhang, Fang Jia, Lili Li, Chenghui Yang, Fuming Qiu, Xiaoyan Jin, Pin Wu, Shanshan Sun, Ke Su, Leyi Zhang, Xiuyan Yu, Xuan Shao   +17 more
doaj   +1 more source

Crosstalk between Thyroid Carcinoma and Tumor-Correlated Immune Cells in the Tumor Microenvironment

, 2023
Thyroid cancer (TC) is the most common malignancy in the endocrine system. Although most TC can achieve a desirable prognosis, some refractory thyroid carcinomas, including radioiodine-refractory differentiated thyroid cancer, as well as anaplastic ...
Mingyuan Song, Hao Zhang, Wei Sun, Qi Liu   +3 more
core   +1 more source

The Cellular Tumor Immune Microenvironment of Childhood Solid Cancers: Informing More Effective Immunotherapies

, 2022
SIMPLE SUMMARY: Cellular immunotherapy has emerged as a novel treatment modality of cancer but is largely inefficient in solid cancers of childhood and adolescence.
Altvater, Bianca, Sareetha Kailayangiri, Kailayangiri, Sareetha, Malcolm Holterhus, Rossig, Claudia, Bianca Altvater, Holterhus, Malcolm, Claudia Rossig   +7 more
core   +1 more source

Construction of a MicroRNA-Based Nomogram for Prediction of Lung Metastasis in Breast Cancer Patients

Frontiers in Genetics, 2021
The lung is one of the most common sites of distant metastasis in breast cancer (BC). Identifying ideal biomarkers to construct a more accurate prediction model than conventional clinical parameters is crucial.
Leyi Zhang, Leyi Zhang, Leyi Zhang, Jun Pan, Jun Pan, Jun Pan, Zhen Wang, Zhen Wang, Zhen Wang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Jian Huang, Jian Huang, Jian Huang   +14 more
doaj   +1 more source

Monitoring immune responses in the tumor microenvironment [PDF]

Current Opinion in Immunology, 2016
Immune monitoring in the tumor microenvironment allows for important insights into immune mechanisms of response and resistance to various cancer treatments; however clinical challenges exist using current strategies. Significant questions remain regarding monitoring of archival versus fresh tissue, assessment of static versus dynamic markers ...
Jennifer A, Wargo, Sangeetha M, Reddy, Alexandre, Reuben, Padmanee, Sharma   +3 more
openaire   +2 more sources

Enhanced Thermogenesis in Triple-Negative Breast Cancer Is Associated with Pro-Tumor Immune Microenvironment

, 2021
Mild cold stress induced by housing mice with a 4T1 triple-negative breast cancer (TNBC) cell implantation model at 22 °C increases tumor growth rate with a pro-tumorigenic immune microenvironment (lower CD8 +T cells, higher myeloid-derived suppressor ...
Vijayashree Murthy, Masanori Oshi, Kazuaki Takabe, Shipra Gandhi, Elizabeth A. Repasky   +4 more
core   +1 more source

CD62Ldim Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer

Frontiers in Oncology, 2020
Lung metastasis is one of the leading causes of death in patients with breast cancer. The mechanism of tumor metastasis remains controversial. Recently, the formation of a pre-metastatic niche has been considered a key factor contributing to breast ...
Zhen Wang, Zhen Wang, Zhen Wang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Lili Li, Lili Li, Lili Li, Zhigang Zhang, Zhigang Zhang, Jun Pan, Jun Pan, Jun Pan, Ke Su, Ke Su, Ke Su, Wuzhen Chen, Wuzhen Chen, Jinfan Li, Fuming Qiu, Fuming Qiu, Jian Huang, Jian Huang, Jian Huang   +24 more
doaj   +1 more source

Multi-Omics Profiling Suggesting Intratumoral Mast Cells as Predictive Index of Breast Cancer Lung Metastasis

Frontiers in Oncology, 2022
Breast cancer lung metastasis has a high mortality rate and lacks effective treatments, for the factors that determine breast cancer lung metastasis are not yet well understood.
Leyi Zhang, Leyi Zhang, Leyi Zhang, Leyi Zhang, Jun Pan, Jun Pan, Jun Pan, Jun Pan, Zhen Wang, Zhen Wang, Zhen Wang, Zhen Wang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Jingxin Jiang, Jingxin Jiang, Jingxin Jiang, Jingxin Jiang, Zhiyuan Zheng, Zhiyuan Zheng, Zhiyuan Zheng, Zhiyuan Zheng, Fang Jia, Fang Jia, Fang Jia, Fang Jia, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Jiahuan Jiang, Jiahuan Jiang, Jiahuan Jiang, Jiahuan Jiang, Ke Su, Ke Su, Ke Su, Ke Su, Guohong Ren, Guohong Ren, Guohong Ren, Guohong Ren, Jian Huang, Jian Huang, Jian Huang, Jian Huang   +52 more
doaj   +1 more source

The Tumor Immune Microenvironment in Pancreatic Ductal Adenocarcinoma: Neither Hot nor Cold

, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic tumor and is associated with poor prognosis and treatment response. The tumor microenvironment (TME) is recognized as an important factor in metastatic progression across cancers ...
Sojwal, Raoul S., Samuel J. S. Rubin, John Gubatan, Rubin, Samuel J. S., Gubatan, John, Raoul S. Sojwal, Rogalla, Stephan, Stephan Rogalla   +7 more
core   +1 more source

The Immune Consequences of Lactate in the Tumor Microenvironment [PDF]

, 2020
The tumor microenvironment consists of complex and dynamic networks of cytokines, growth factors, and metabolic products. These contribute to significant alterations in tissue architecture, cell growth, immune cell phenotype, and function. Increased glycolytic flux is commonly observed in solid tumors and is associated with significant changes in ...
Harmon, Cathal, O'Farrelly, Cliona, Robinson, Mark W.   +2 more
openaire   +3 more sources