Results 41 to 50 of about 469,202 (307)
Frontiers in Oncology, 2020 Lung metastasis is one of the leading causes of death in patients with breast cancer. The mechanism of tumor metastasis remains controversial. Recently, the formation of a pre-metastatic niche has been considered a key factor contributing to breast ...
Zhen Wang +24 more
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Frontiers in Oncology, 2022 Breast cancer lung metastasis has a high mortality rate and lacks effective treatments, for the factors that determine breast cancer lung metastasis are not yet well understood.
Leyi Zhang +52 more
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Monitoring immune responses in the tumor microenvironment [PDF]
Current Opinion in Immunology, 2016 Immune monitoring in the tumor microenvironment allows for important insights into immune mechanisms of response and resistance to various cancer treatments; however clinical challenges exist using current strategies. Significant questions remain regarding monitoring of archival versus fresh tissue, assessment of static versus dynamic markers ...
Jennifer A, Wargo +3 more
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Immune suppressive mechanisms in the tumor microenvironment [PDF]
Current Opinion in Immunology, 2016 Effective immunotherapy, whether by checkpoint blockade or adoptive cell therapy, is limited in most patients by a key barrier: the immunosuppressive tumor microenvironment. Suppression of tumor-specific T cells is orchestrated by the activity of a variety of stromal myeloid and lymphoid cells.
Munn, David H, Bronte, Vincenzo
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Role of the tumor immune microenvironment in tumor immunotherapy (Review)
Oncology Letters, 2021 Tumor immunotherapy is considered to be a novel and promising therapy for tumors and it has recently become a hot research topic. The clinical success of tumor immunotherapy has been notable, but it has been less than totally satisfactory because tumor immunotherapy has performed poorly in numerous patients although it has shown appreciable efficacy in
Zhou, Changsheng +4 more
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Acetylcholine From Tuft Cells: The Updated Insights Beyond Its Immune and Chemosensory Functions
Frontiers in Cell and Developmental Biology, 2020 Tuft cells, rare solitary chemosensory cells, are distributed in mucosal epithelium throughout mammalian organs. Their nomenclatures are various in different organs and may be confused with other similar cells.
Jun Pan +10 more
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Cellular interactions in the tumor microenvironment: the role of secretome [PDF]
, 2019 Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix ...
Castelo-Branco, Pedro +6 more
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Immune aspects of the breast tumor microenvironment [PDF]
Breast Cancer Management, 2013 The immune response in the tumor microenvironment is complex, consisting of cells from both the adaptive and innate immune systems. The phenotype and function of these cells are dictated by cytokines present in the microenvironment, as well as by the interactions of these cells with the tumor cells and each other.
Akhil, Chawla +3 more
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Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer [PDF]
, 2015 Purpose: The tumor microenvironment is recognized as an important determinant of progression and outcome in colorectal cancer. The aim of the present study was to evaluate a novel tumor microenvironment–based prognostic score, based on histopathologic ...
Edwards, Joanne +6 more
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Metabolites and Immune Response in Tumor Microenvironments
Cancers, 2023 The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing the levels of macro- and micronutrients and by releasing hormones and cytokines that recruit immunosuppressive immune cells.
Salvatore Cortellino, Valter D. Longo
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