Results 41 to 50 of about 354,584 (265)

Immunometabolism in the tumor microenvironment and its related research progress

Frontiers in Oncology, 2022
The tumor immune microenvironment has been a research hot spot in recent years. The cytokines and metabolites in the microenvironment can promote the occurrence and development of tumor in various ways and help tumor cells get rid of the surveillance of ...
Ziheng Zhang, Yajun Hu, Yuefeng Chen, Zhuoneng Chen, Yexin Zhu, Mingmin Chen, Jichu Xia, Yixuan Sun, Wenfang Xu   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma

Frontiers in Genetics
IntroductionSmall nucleolar RNA (snoRNA) mediates RNA modifications, including 2′-O-methylation (Nm) and pseudouridine (Ψ), which has been proven to impact tumor progression.
Minglu Zhang, Minglu Zhang, Minglu Zhang, Minglu Zhang, Jianbo He, Jianbo He, Jianbo He, Jianbo He, Rao Fu, Rao Fu, Rao Fu, Rao Fu, Guojian Bao, Guojian Bao, Guojian Bao, Yijun Lu, Yijun Lu, Yijun Lu, Zechuan Zhang, Zechuan Zhang, Zechuan Zhang, Jiawu Yan, Jiawu Yan, Jiawu Yan, Jialu Ding, Jialu Ding, Jialu Ding, Fei Yang, Fei Yang, Fei Yang, Fei Yang, Beicheng Sun, Beicheng Sun, Beicheng Sun, Beicheng Sun   +34 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Metabolites and Immune Response in Tumor Microenvironments

Cancers, 2023
The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing the levels of macro- and micronutrients and by releasing hormones and cytokines that recruit immunosuppressive immune cells.
Salvatore Cortellino, Valter D. Longo
openaire   +2 more sources

Sexual dimorphism in cancer: molecular mechanisms and precision oncology perspectives

Biology of Sex Differences
Sex differences play a crucial role in determining tumor incidence, treatment sensitivity, and prognosis among men and women. However, current clinical cancer treatment strategies fail to account for these differences.
Zhen Wang, Hanwen Hu, Yunjia Bao, Guohong Ren, Chenghui Yang   +4 more
doaj   +1 more source

Androgen Receptor in Breast Cancer: From Bench to Bedside

Frontiers in Endocrinology, 2020
Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related mortality in women. Androgen receptor (AR) is frequently expressed in diverse BC subtypes.
Mengyao Chen, Mengyao Chen, Mengyao Chen, Yunben Yang, Yunben Yang, Yunben Yang, Kai Xu, Lili Li, Lili Li, Lili Li, Jian Huang, Jian Huang, Jian Huang, Fuming Qiu, Fuming Qiu, Fuming Qiu   +15 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Tumor microenvironment-mediated immune tolerance in development and treatment of gastric cancer

Frontiers in Immunology, 2022
Tumor microenvironment is the general term for all non-cancer components and their metabolites in tumor tissue. These components include the extracellular matrix, fibroblasts, immune cells, and endothelial cells.
Yuanda Liu, Changfeng Li, Yaoping Lu, Chang Liu, Wei Yang   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source