Results 1 to 10 of about 192,885 (309)

Triple-Negative Breast Cancer [PDF]

New England Journal of Medicine, 2010
Recent advances in biological characterization of breast cancer have eventually increased our understanding of underlying tumour biology. While for endocrine responsive and Her2-positive disease different molecular targeted therapies are available, up to now no specific targeted approach for triple-negative breast cancer has been developed.
William D Foulkes, Ian E Smith, Jorge S Reis-Filho   +2 more
exaly   +11 more sources

Triple-Negative Breast Cancer

International Journal of Breast Cancer, 2012
Ever since the seminal work that was published by Perou et al., triple-negative breast cancer (TNBC) has become a common lexicon among clinicians who care for patients with breast cancer. Beside portending a poor outcome, TNBC is unique in that, unlike the hormone-positive and Her-2-positive cancer cells, it lacks target specific therapy.
Quyen D. Chu, Tari King, Thelma Hurd
doaj   +3 more sources

Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer

Journal for ImmunoTherapy of Cancer, 2022
Background Triple-negative breast cancer is characterized by a poor prognosis and lack of targeted treatments, and thus, new targeting markers and therapeutic strategies are urgently needed.
Cong Chen, Linbo Wang, Xun Zhang, Ling Xu, Misha Mao, Yongxia Chen, Jingjing Yang, Yifan Cheng, Feiyang Ji, Jichun Zhou, Zhaoqing Li, Siwei Ju, Jiahang Zhang   +12 more
doaj   +1 more source

Triple Negative Breast Cancer [PDF]

Klinicka onkologie, 2015
In the Czech Republic, around 6,500 women get breast cancer each year; out of this number, nearly 1,000 women are triple negative subtype. Triple negative breast cancer is characterized by lack of expression of α-estrogen, progesterone, and HER2 receptors.
J, Navrátil, P, Fabian, M, Palácová, K, Petráková, R, Vyzula, M, Svoboda   +5 more
openaire   +2 more sources

Clinical Implications of iNOS Levels in Triple-Negative Breast Cancer Responding to Neoadjuvant Chemotherapy. [PDF]

PLoS ONE, 2015
Triple-negative breast cancer is a high-risk breast cancer with poor survival rate. To date, there is a lack of targeted therapy for this type of cancer. One unique phenomenon is that inflammatory breast cancer is frequently triple negative.
Zining Jin, Wenqian Wang, Nan Jiang, Lei Zhang, Yiming Li, Xiaoyin Xu, Shouliang Cai, Liang Wei, Xuhong Liu, Guanglei Chen, Yizhen Zhou, Cheng Liu, Zhan Li, Feng Jin, Bo Chen   +14 more
doaj   +1 more source

Immunotherapy for Triple-Negative Breast Cancer [PDF]

Pharmaceutics, 2021
Triple-negative breast cancer (TNBC) is characterized by extensive tumor heterogeneity at both the pathologic and molecular levels, particularly accelerated aggressiveness, and terrible metastasis. It is responsible for the increased mortality of breast cancer patients.
Yifeng Cao, Chuyang Chen, Yi Tao, Weifeng Lin, Ping Wang   +4 more
openaire   +3 more sources

Metabolic Reprogramming in Triple-Negative Breast Cancer

Frontiers in Oncology, 2020
Metabolic reprogramming is an emerging hallmark of cancer cells, in which cancer cells exhibit distinct metabolic phenotypes to fuel their proliferation and progression.
Xiangyu Sun, Mozhi Wang, Mengshen Wang, Xueting Yu, Jingyi Guo, Tie Sun, Xinyan Li, Litong Yao, Haoran Dong, Yingying Xu   +9 more
doaj   +1 more source

HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer

Cell Death and Disease, 2022
Triple-negative breast cancer is still a difficult point in clinical treatment at present, and a deep study of its pathogenesis has great clinical value. Therefore, our research mainly focuses on exploring the progression of triple-negative breast cancer
Misha Mao, Yunlu Jia, Yongxia Chen, Jingjing Yang, Ling Xu, Xun Zhang, Jichun Zhou, Zhaoqing Li, Cong Chen, Siwei Ju, Linbo Wang   +10 more
doaj   +1 more source

Molecular characteristics and metastasis predictor genes of triple-negative breast cancer: a clinical study of triple-negative breast carcinomas. [PDF]

PLoS ONE, 2012
BackgroundTriple-negative breast cancer is a subtype of breast cancer with aggressive tumor behavior and distinct disease etiology. Due to the lack of an effective targeted medicine, treatment options for triple-negative breast cancer are few and ...
Wen-Hung Kuo, Yao-Yin Chang, Liang-Chuan Lai, Mong-Hsun Tsai, Chuhsing Kate Hsiao, King-Jen Chang, Eric Y Chuang   +6 more
doaj   +1 more source

Theranostics for Triple-Negative Breast Cancer

Diagnostics, 2023
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis. Current endocrine therapy or anti HER-2 therapy is not available for these patients. Chemotherapeutic treatment response varies among patients due to the disease heterogeneity. To overcome these challenges, theranostics for treating TNBC have been widely
Hyeryeon Choi, Kwangsoon Kim
openaire   +3 more sources