Results 31 to 40 of about 6,967,236 (252)

Qualitative exploration of patients’ experiences with Intrabeam TARGeted Intraoperative radioTherapy (TARGIT-IORT) and External-Beam RadioTherapy Treatment (EBRT) for breast cancer

open access: yesBMJ Open
Objective To gather a deep qualitative understanding of the perceived benefits and impacts of External-Beam RadioTherapy (EBRT) and TARGeted Intraoperative radioTherapy (TARGIT-IORT) using Intrabeam to assess how the treatments affected patient/care ...
Jayant S Vaidya   +10 more
doaj   +1 more source

Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing

open access: yes, 2017
Background: MicroRNAs (miRNAs) are short, non-coding RNA molecules that play critical roles in human malignancy. However, the regulatory characteristics of miRNAs in triple-negative breast cancer, a phenotype of breast cancer that does not express the ...
Chang, Yao-Yin;Kuo, Wen-Hung;Hung, Jui-Hui;Lee, Chien-Yueh;Lee, Yung-Hua;Chang, Ya-Chu;Lin, Wen-Chun;Shen, Cheng-Ying;Huang, Chiun-Sheng;Hsieh, Fon-Jou;Lai, Liang-Chuan;Tsai, Mong-Hsun;Chang, King-Jen;Chuang, Eric Y.   +1 more
core   +1 more source

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk [PDF]

open access: yes, 2013
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were
Side, Lucy E.,   +999 more
core   +4 more sources

GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation

open access: yes, 2018
Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, lacking effective targeted therapies, and whose underlying mechanisms are still unclear.
Liu, Jingjing   +7 more
core   +1 more source

Safety analyses from the phase 3 ASCENT trial of sacituzumab govitecan in metastatic triple-negative breast cancer [PDF]

open access: yes, 2022
Breast cancer; Drug safetyCàncer de mama; Seguretat dels medicamentsCáncer de mama; Seguridad de los medicamentosSacituzumab govitecan (SG) is an anti-Trop-2 antibody-drug conjugate with an SN-38 payload.
Tolaney, Sara M   +6 more
core   +1 more source

Management Options in Triple-Negative Breast Cancer

open access: yesBreast Cancer: Basic and Clinical Research, 2011
Notorious for its poor prognosis and aggressive nature, triple-negative breast cancer (TNBC) is a heterogeneous disease entity. The nature of its biological specificity, which is similar to basal-like cancers, tumors arising in BRCA1 mutation carriers ...
Christina A. Minami   +2 more
doaj   +2 more sources

Prevalence of BRCA1 and BRCA2 gene mutations in Chinese patients with high‐risk breast cancer

open access: yesMolecular Genetics & Genomic Medicine, 2019
Background Breast cancer is the most common cancer among women worldwide. Here, we report the prevalence of BRCA1/2 mutations in patients with high‐risk breast cancer from Inner Mongolia and Jilin, China, which was a part of a nationwide project on the ...
Xiaozhen Wang   +20 more
doaj   +1 more source

Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium.

open access: yes, 2007
Association studies in large series of breast cancer patients can be used to identify single-nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility.
Pharoah, Paul DP   +22 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan.

open access: yesPLoS ONE, 2011
Discrepancies in the prognosis of triple negative breast cancer exist between Caucasian and Asian populations. Yet, the gene signature of triple negative breast cancer specifically for Asians has not become available. Therefore, the purpose of this study
Lee H Chen   +9 more
doaj   +1 more source

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