Results 41 to 50 of about 131,135 (260)
The Challenge of Triple Negative Breast Cancers [PDF]
Indian Journal of Clinical Biochemistry, 2014 The role of hormones (estrogen) in breast carcinogenesis was recognized even in the nineteenth century. About 70 % of breast cancers express estrogen receptors (ER), and ER positive tumors proliferate in response to estrogen. ER positive tumors had better prognosis compared to ER negative ones.
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
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Tumor Biology, 2017 Breast cancer has attracted substantial attention as one of the major cancers causing death in women. It is crucial to find potential biomarkers of prognostic value in breast cancer. In this study, the expression pattern of anterior gradient protein 2 in
Jilong Guo, Guohua Gong, Bin Zhang
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Targeting KK-LC-1 inhibits malignant biological behaviors of triple-negative breast cancer
Journal of Translational Medicine, 2023 Background Cancer/testis antigens (CTAs) participate in the regulation of malignant biological behaviors in breast cancer. However, the function and mechanism of KK-LC-1, a member of the CTA family, in breast cancer are still unclear.
Xudong Zhu +3 more
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Association of Parity with Triple Negative Breast Cancer, A Case Control Study
Pakistan Armed Forces Medical Journal, 2023 Objective: To find out association between number of children and triple negative breast cancer among females presenting at a tertiary care hospital of Karachi. Study Design: Case control study.
Batool Aslam Memon +5 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The Cancer Journal, 2021 Abstract Triple-negative breast cancer (TNBC) is pathologically defined by lack of expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 amplification and portends an aggressive clinical course with worse outcomes compared with other breast cancers.
Sara E, Nunnery +2 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer. [PDF]
PLoS ONE, 2012 A major challenge in breast cancer therapy is the lack of an effective therapeutic option for a particularly aggressive subtype of breast cancer, triple-negative breast cancer.
Yanfeng Qi +6 more
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Imaging of triple-negative breast cancer
Annals of Oncology, 2012 Although triple-negative breast cancer (TNBC) has been studied extensively in the oncology and pathology literature, there are few reports on imaging features. Emerging data suggest that imaging features of TNBC are substantially different from other primary breast cancer immunotypes. In this work, we reviewed multi-modality imaging features of primary
B E, Dogan, L W, Turnbull
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