Results 41 to 50 of about 192,885 (309)

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk [PDF]

open access: yes, 2013
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were
Side, Lucy E.,   +999 more
core   +1 more source

Management Options in Triple-Negative Breast Cancer

open access: yesBreast Cancer: Basic and Clinical Research, 2011
Notorious for its poor prognosis and aggressive nature, triple-negative breast cancer (TNBC) is a heterogeneous disease entity. The nature of its biological specificity, which is similar to basal-like cancers, tumors arising in BRCA1 mutation carriers ...
Christina A. Minami   +2 more
doaj   +2 more sources

A Review of Triple-Negative Breast Cancer

open access: yesCancer Control, 2010
Background An estimated 1 million cases of breast cancer are diagnosed annually worldwide. Of these, more than 170,000 are described as triple-negative. Triple-negative breast cancer (TNBC) is defined by the lack of protein expression of estrogen receptor (ER) and progesterone receptor (PR) and the absence of ...
Roohi, Ismail-Khan, Marilyn M, Bui
openaire   +2 more sources

Safety analyses from the phase 3 ASCENT trial of sacituzumab govitecan in metastatic triple-negative breast cancer [PDF]

open access: yes, 2022
Breast cancer; Drug safetyCàncer de mama; Seguretat dels medicamentsCáncer de mama; Seguridad de los medicamentosSacituzumab govitecan (SG) is an anti-Trop-2 antibody-drug conjugate with an SN-38 payload.
Tolaney, Sara M   +6 more
core   +1 more source

Qualitative exploration of patients’ experiences with Intrabeam TARGeted Intraoperative radioTherapy (TARGIT-IORT) and External-Beam RadioTherapy Treatment (EBRT) for breast cancer

open access: yesBMJ Open
Objective To gather a deep qualitative understanding of the perceived benefits and impacts of External-Beam RadioTherapy (EBRT) and TARGeted Intraoperative radioTherapy (TARGIT-IORT) using Intrabeam to assess how the treatments affected patient/care ...
Jayant S Vaidya   +10 more
doaj   +1 more source

Differences in breast cancer hormone receptor status in ethnic groups: a London population.

open access: yes, 2013
BACKGROUND: Triple negative breast cancer (TNBC) is associated with different ethnic groups in the United States (US), however this has not previously been examined in a population-based study within the United Kingdom (UK). METHODS: Electronic pathology
Jack, Ruth H   +13 more
core   +1 more source

Bcl2 is an independent prognostic marker of triple negative breast cancer (TNBC) and predicts response to anthracycline combination (ATC) chemotherapy (CT) in adjuvant and neoadjuvant settings

open access: yes, 2013
Background: TNBC represents a heterogeneous subgroup of BC with poor prognosis and frequently resistant to CT. Material and methods: The relationship between Bcl2 immunohistochemical protein expression and clinicopathological outcomes was assessed in 736
Ball, G   +7 more
core   +1 more source

Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing

open access: yes, 2017
Background: MicroRNAs (miRNAs) are short, non-coding RNA molecules that play critical roles in human malignancy. However, the regulatory characteristics of miRNAs in triple-negative breast cancer, a phenotype of breast cancer that does not express the ...
Chang, Yao-Yin;Kuo, Wen-Hung;Hung, Jui-Hui;Lee, Chien-Yueh;Lee, Yung-Hua;Chang, Ya-Chu;Lin, Wen-Chun;Shen, Cheng-Ying;Huang, Chiun-Sheng;Hsieh, Fon-Jou;Lai, Liang-Chuan;Tsai, Mong-Hsun;Chang, King-Jen;Chuang, Eric Y.   +1 more
core   +1 more source

Breast cancer receptor status assessment and clinicopathological association in Nigerian women: A retrospective analysis

open access: yes, 2014
Background: Breast cancer markers are becoming increasingly important in breast cancer research due to their impact on prognosis, treatment and survival.
Ayodele, Sanni D.   +5 more
core   +1 more source

Prevalence of BRCA1 and BRCA2 gene mutations in Chinese patients with high‐risk breast cancer

open access: yesMolecular Genetics & Genomic Medicine, 2019
Background Breast cancer is the most common cancer among women worldwide. Here, we report the prevalence of BRCA1/2 mutations in patients with high‐risk breast cancer from Inner Mongolia and Jilin, China, which was a part of a nationwide project on the ...
Xiaozhen Wang   +20 more
doaj   +1 more source

Home - About - Disclaimer - Privacy