Results 61 to 70 of about 6,967,236 (252)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong +6 more
wiley +1 more source
Prognosis and adjuvant treatment effects in very young women (below 35 years) with operable breast cancer [PDF]
, 2009 Background: There is limited knowledge about prognosis of selected breast cancer subtypes among very young women Patients and Methods: We explored patterns of recurrence by age according to four immunohistochemically-defined tumor subtypes: triple ...
Cancello, Giuseppe
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Overcoming Drug Resistance by Paclitaxel Resistance in Triple-Negative Breast Cancer. [PDF]
Adv Sci (Weinh)In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Chen B, Wang Y, Li T, Guo C, Xie Z, Zhang Z, Han X, Wang W, Wang J, Ma X, Min Y. +10 more
europepmc +2 more sources
THE ROLE OF TUMOR-INFILTRATING LYMPHOCYTES IN TRIPLE NEGATIVE BREAST CANCER [PDF]
Romanian Journal of Medical Practice, 2018 Triple-negative breast cancer (TNBC), which lacks the expression of hormone receptors and human epidermal growth factor receptor-2 (HER2) represents the breast cancer subtype with the poorest prognosis.
Anca Zgura, Simona Carniciu, Laurentia Gales, Rodica Anghel +3 more
doaj +1 more source
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer [PDF]
, 2013 IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating ...
Gee, Julia M. W., Hulbert-Williams, Nicholas J., Anderson, Annie, Martin, S.G., Stingl, J., Key, Timothy, Hunter, MS, Walker, Rosemary, Martin, SG, Stephen Hiscox, O’Connor, Rosemary, Smalley, Matthew J., Aboagye, Eric, Williams, K.J., Christine J Watson, Annie S Anderson, Robert B Clarke, Bundred, Nigel, Tutt, Andrew N J, Jo Armes, Evans, D, Brown, N.J., Smalley, Matthew J, Clarke, R.B., Charles H. Streuli (7669838), Eric O Aboagye, Bundred, Nigel J., Groves, Ashley, Aboagye, Eric O., John M. Saxton (7244180), Watson, Christine, Watson, C.J., Montserrat Garcia-Closas (89866), Palmieri, C., Anderson, Annie S.; id_orcid, Miller, WR, Moss, SM, Evans, D., Burchell, JM, Nicola J. Brown (7596590), John F. Marshall (7957925), John M Saxton, Amanda J Harvey, Eccles, Suzanne A., Flanagan, James, Bharat Jasani, Fedor Berditchevski, Pharoah, Paul D.P., Marshall, John F., Stingl, John, Peter Schmid, Macdougall, J.E., Cliona C. Kirwan (3934682), Duffy, Stephen W, Leach, M.O., Stein, R., Eccles, Suzanne A, Hunter, Myra, Miller, William R., Howell, Anthony, Stewart G Martin, Edwards, Dylan R., Kunkler, IH, Silva, IDOSS, Miles, D.W., Paul D P Pharoah, Ian H. Kunkler (7957919), Young, L.S., Evans, DG, Galina Velikova, Goh, V., Kong, A., Jasani, Bharat, Watson, CJ, Paul DP Pharoah (7957952), Gee, JM, Streuli, CH, Berditchevski, F., Walker, R.A., Nick Hulbert-Williams, Groves, Ashley M., Moss, Sue, Sahai, E, Jones, LJ, Goh, Vicky, Leach, Martin O., Charlotte E Coles, Gary JR Cook, Berditchevski, F, Hennessy, Bryan T., Carroll, J.S., Gee, Julia MW, Jennifer E Macdougall, Armes, Jo, Garcia-Closas, M., Aboagye, Eric O, Martin, L.A., O'Connor, J.P.B., Anthony Howell (23576), Key, Timothy J, Mullan, P, Kaye J Williams, Harvie, Michelle N., Brown, NJ, Miles, David, Harvey, AJ, Rakha, Emad A, Isabel dos Santos Silva, Thompson, Alastair M., Palmieri, C, Miller, W.R., David W Miles, Velikova, Galina, Moss, S.M., Bryant, Helen E, Cox, A, Jo Armes (3480905), Reed, E., Eccles, Diana M., Marshall, JF, Cook, Gary J. R., William R Miller, Pharoah, P.D.P., Anderson, Annie S, Fedor Berditchevski (3827920), Duffy, SW, Young, Leonie, Nicola J Brown, Martin, Stewart, Hubbard, G., Saxton, John M., Dekker, Lodewijk, Brown, Nicola, Bundred, N.J., Martin, LA, Cox, Angela, Armes, J., William M. Gallagher (265756), Charlotte E. Coles (7688222), Andrew N J Tutt, Alastair M Thompson, Aboagye, EO, Simak Ali, Paul Mullan (6534653), Jones, Louise, Rosemary O'Connor (94873), Coles, Charlotte E, Evans, D. Gareth, Burchell, Joy, Jeremy P. Blaydes (7957853), Hiscox, Stephen, Deborah F. Fenlon (7957892), Robert Stein, Speirs, Valerie, Simon P. Robinson (7957958), Hulbert-Williams, N., Joy M Burchell, Claire Foster (768031), Julia MW Gee (7957898), Julia M W Gee, D Gareth Evans (7957889), Michelle Harvie (3455429), Gee, Julia M.W., Easton, Douglas F, Gescher, A.J., Jasani, B., Key, Timothy J., Bryan T Hennessy, Smalley, Matthew John, O'Connor, JP, Williams, Kaye J, Cook, Gary, Bryant, Helen E., Eccles, DM, O’Connor, JPB, Schmid, P., David W. Miles (7957937), Rakha, Emad A., Robinson, Simon P., Sue M Moss, Blaydes, J.P., John F Marshall, Jason S Carroll, Langdon, Simon P, Cook, Gary Jr, Fenlon, D.F., Macdougall, Jennifer E., Sue M. Moss (7957943), Douglas F. Easton (7957880), Suzanne A Eccles, Evans, D.G., Angela Cox (76913), Harvey, A.J., Rosemary A Walker, Howell, A., Stein, Robert, Evans, D.Gareth, Martin, Stewart G., Edwards, Dylan, David J. Mann (2820133), O'Connor, R, Jennifer E. Macdougall (7957934), Hennessy, Bryan T, Edwards, Joanne, O'Connor, James P. B., Carroll, Jason, Anderson, A.S., Gill Hubbard (3403994), Robinson, SP, Groves, Ashley M, Hulbert-Williams, N, Watson, Christine J, Amanda J. Harvey (7957904), Kirwan, Cliona C.; id_orcid, Speirs, V, Campbell, AM, Cook, Gary J., Bryant, Helen, Coles, Charlotte E., Fenlon, Deborah F., Martin, Lesley, Blaydes, Jeremy P, Martin O Leach, Erik Sahai, Ashley M. Groves (7957901), Williams, Kaye J., Langdon, Simon P., O’Connor, James P., Bryant, HE, Edwards, J, Blaydes, JP, Emad A Rakha, Morris, Joanna R., Groves, A.M., Louise J Jones, Thompson, AM, Easton, Douglas F., Dekker, LV, Jasani, B, Harvey, Amanda J., Howell, S.J., Anna M Campbell, Saxton, JM, Vicky Goh (577982), Leach, Martin O, Stephen W Duffy, Tutt, Andrew NJ, Ali, S., Blaydes, Jeremy P., Howell, Sacha J.; id_orcid, Louise J. Jones (7957916), Harvie, Michelle, Clarke, Robert B, Lesley Ann Martin, Garcia-Closas, Montserrat, Kunkler, Ian H., Angela Cox, Leach, MO, Fenlon, Deborah, dos Santos Silva, Isabel, Leonie Young (7895759), Pharoah, Paul D. P., Harvey, Amanda, Rakha, Emad, Jones, L.J., Morris, JR, Campbell, Anna, Kunkler, Ian H, Reed, Elizabeth, Douglas F Easton, Deborah F Fenlon, Berditchevski, Fedor, Coles, C.E., Gallagher, W.M., Carlo Palmieri (681317), Howell, A, Brennan, K, Rakha, EA, Rosemary A. Walker (7580297), Jeremy P Blaydes, Duffy, Stephen, Matthew J. Smalley (7957961), Sacha J Howell, Gescher, Andy, Macdougall, JE, Elizabeth Reed (3138513), Natrajan, R., O'Connor, R., Montserrat Garcia-Closas, Bundred, Nigel J, Nicola J. Curtin (351064), Holen, Ingunn, Carroll, JS, Goh, Vicky; id_orcid, Alastair M. Thompson (7957970), Bryan Hennessy (7898999), Cook, GJR, Brown, Nicola J, Reed, E, Kirwan, CC, Hunter, Myra S., Walker, Rosemary A., Robinson, S.P., Michelle Harvie, Duffy, S.W., Saxton, John, Ingunn Holen, Suzanne A Eccles (7957850), Brennan, K., Gallagher, William, Rosemary O’Connor, Isabel Dos Santos Silva (7957874), John Stingl, Andy J. Gescher (7671179), Joanna R Morris, Annie S. Anderson (6298127), Morris, Jo; id_orcid, Langdon, Simon, Rachel Natrajan (7957946), Ali, S, Hubbard, Gill, Vicky Goh, Sacha J. Howell (7957907), Smalley, M.J., Holen, I, Sahai, E., Helen E Bryant, Edwards, Dylan R, Edwards, D.R., Cliona C Kirwan, Stein, R, Simon P Robinson, Timothy J. Key (7755380), James M Flanagan, Martin, Lesley Ann, Nick Hulbert-Williams (7957910), Morris, Joanna, Brown, Nicola J., Silva, Isabel dos Santos, Nicola J Curtin, Foster, Claire, Kaye J. Williams (7957967), Paul Mullan, Nigel J. Bundred (7957859), Curtin, NJ, Gee, Julia M W, Eccles, Diana, Campbell, Anna M, Streuli, C.H., Tutt, Andrew, Fenlon, Deborah F, Clarke, Robert B., Mullan, P., Silva, IDS, Gee, J.M.W., Morris, J.R., Valerie Speirs (1679), O'Connor, James, Cook, Gary J R, O’Connor, James P.B., Campbell, A.M., Easton, DF, Watson, Christine J., Goh, V, Bryant, H.E., Eric O. Aboagye (309960), Marshall, J.F., Howell, Anthony; id_orcid, Burchell, Joy M, Tutt, AN, Easton, Douglas, Tutt, A.N.J., Jones, Louise J, Streuli, Charles H, Hiscox, S., Schmid, Peter, Joanne Edwards (589089), Gallagher, William M, Stingl, J, Dekker, L.V., Claire Foster, Robinson, Simon P, Curtin, Nicola, Gee, Julia, Tutt, ANJ, Howell, Sacha, Saxton, J.M., Foster, C., Miles, David W, Erik Sahai (829065), Thompson, A.M., Mullan, Paul, Kirwan, Cliona C, James PB O’Connor, Mann, DJ, Rakha, E.A., Pharoah, Paul DP, Helen E. Bryant (7957856), Burchell, Joy M., Natrajan, R, Harvie, M, Carlo Palmieri, Gescher, Andy J, Macdougall, Jennifer E, Hubbard, G, Hulbert-Williams, Nick, Mann, David, Clarke, Robert, Cook, Gary J.R., Anthony Howell, Dekker, Lodewijk V, Hennessy, B.T., Young, Leonie S., Joy M. Burchell (7957862), Foster, C, Key, T.J., Moss, Sue M, Williams, Kaye, Peter Schmid (81036), D Gareth Evans, Hubbard, Gill; id_orcid, Ashley M Groves, Curtin, Nicola J., Gescher, AJ, Joanna R. Morris (7957940), Clarke, RB, Streuli, Charles, Palmieri, Carlo, Martin O. Leach (454145), Mann, David J., Ingunn Holen (3637012), Marshall, John, Simon P Langdon, Bundred, NJ, Gill Hubbard, Keith Brennan (1659), Young, LS, Timothy J Key, Kong, A, dos Santos Silva, I, Eccles, SA, Marshall, John F, Miller, William, Fenlon, DF, Charles H Streuli, Langdon, SP, Pharoah, Paul, Hunter, M.S., Streuli, Charles H., Matthew J Smalley, Smalley, MJ, Kirwan, Cliona C., Christine J. Watson (7585901), Gescher, Andy J., Tutt, Andrew N. J., Kunkler, Ian, Robinson, Simon, Keith Brennan, O’Connor, R, Eccles, S.A., Cook, G.J.R., Valerie Speirs, Kong, Hee, Curtin, N.J., Dylan R. Edwards (7957886), Hiscox, S, Edwards, DR, Gary Jr Cook (7957868), Nigel J Bundred, Eccles, Diana M, James M. Flanagan (7957895), Leach, Martin, Speirs, V., James PB O'Connor (7957949), Howell, Sacha J., Joanne Edwards, Coles, Charlotte, Emad A. Rakha (7957955), Key, TJ, Carroll, Jason S, Rachel Natrajan, Stephen W. Duffy (7957877), Walker, RA, Kong, Anthony, Eccles, Suzanne, Miles, DW, Gallagher, William M., Curtin, Nicola J, Stewart G. Martin (7957931), Ali, Simak, Jones, Louise J., Bharat Jasani (4954081), Howell, Sacha J, Mann, David J, Valikova, G., Dylan R Edwards, Macdougall, Jennifer, Blaydes, Jeremy, Miles, David W., Miller, William R, Burchell, Joy M; id_orcid, Kunkler, I.H., Anderson, AS, Armes, J, Groves, AM, Diana M. Eccles (7957883), Mann, D.J., Andy J Gescher, Flanagan, James M., O'Connor, James P B, Eccles, D.M., Garcia-Closas, M, Flanagan, J.M., Kirwan, C.C., Pharoah, Paul D P, Leonie S Young, Ian H Kunkler, Anderson, Annie S., Hennessy, Bryan, dos Santos Silva, I., Deborah Fenlon, Myra S Hunter, O'Connor, JPB, Galina Velikova (3069645), Hiscox, Stephen Edward, Carroll, Jason S., David J Mann, Holen, I., Campbell, Anna M., Flanagan, JM, Aboagye, E.O., Pharoah, PD, Velikova, G, Harvey, Amanda J, Martin, Stewart G, Sahai, Erik, Martin, L, Stephen Hiscox (361114), Cook, Gary JR; id_orcid, Coles, CE, Williams, KJ, Silva, IS, Morris, Joanna R, Lodewijk V Dekker, Hennessy, BT, Thompson, Alastair M, Simak Ali (12335), Pharoah, PDP, Saxton, John M, Cook, GJ, Evans, D. G., Andrew NJ Tutt (7957964), Simon P. Langdon (7957922), Dekker, Lodewijk V., Anna M. Campbell (7957865), Moss, Sue M., Gee, JMW, Lesley A. Martin (7957928), Harvie, M., Clarke, Robert; id_orcid, O'Connor, Rosemary, Natrajan, Rachel, Cox, A., Edwards, J., Young, Leonie S, Anthony Kong, Smalley, Matthew, Diana M Eccles, William M Gallagher, Elizabeth Reed, Schmid, P, Brennan, Keith, Langdon, S.P., Duffy, Stephen W., Easton, D.F., Walker, Rosemary A, Kirwan, Cliona, Flanagan, James M, O'Connor, James Pb, Gallagher, WM, Martin, Lesley A., Anthony Kong (94738), Gee, Julia Margaret Wendy, Howell, SJ, Hunter, Myra S, Myra S. Hunter (7957913), Lodewijk V V. Dekker (7957871), William R. Miller (1372755), Robert Stein (1704328), John Stingl (444979), Jason S. Carroll (7901276), Burchell, J.M., Robert B. Clarke (7948805), Robinson, S P, Bryant, H E, Key, T J, Easton, D F, Watson, C J, Fenlon, D F, Pharoah, P D P, Tutt, A N J, Groves, A M, Jones, L J, Leach, M O, Coles, C E, Flanagan, J M, Gescher, A J, Mann, D J, Martin, S G, Morris, J R, Silva, I S, Walker, R A, Langdon, S P, Anderson, A S, Miller, W R, Moss, S M, Gallagher, W M, Burchell, J M, Saxton, J M, Rakha, E A, Harvie, Michelle N, Duffy, S W, Harvey, A J, Hunter, M S, Thompson, A M, Marshall, J F, Curtin, N J, Blaydes, J P, Hennessy, B T, Young, L S, Hulbert-Williams, Nick; id_orcid, Aboagye, E O, Brown, N J, Eccles, D M, Kunkler, I H, Smalley, M J, Eccles, S A, Edwards, D R, Dekker, L V, Macdougall, J E, Campbell, A M, Carroll, J S, Miles, D W, Cook, G J R, Evans, D Gareth R, Gee, J M W +645 more
core +3 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun +9 more
wiley +1 more source
Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. [PDF]
, 2012 Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility ...
Dutra-Clarke, Ana, CIMBA, SWE-BRCA, Bruno Buecher, Theo A. Van Os, Dorfling, Cecelia M., Beesley, Jonathan, Donaldson, A., Mark H Greene, Verhoef, Senno, Tihomirova, L, Pankratz, Vernon, Engel, C., Muy-Kheng Tea, Barrowdale, D., Douglas, F., Maria A Caligo, Lespérance, B, Anne Marie Gerdes, Barkardottir, Rosa B, Varon-Mateeva, Raymonda, Ozcelik, Hilmi, Kast, K, Raymonda Varon Mateeva, Hurteau, J., Meindl, A., Heli Nevanlinna, Diez, O., Patricia A. Ganz, Harbst, K, Jennifer T Loud, de la Hoya, Miguel, Odunsi, K, Andrew K. Godwin, Jan C. Oosterwijk, Dorfling, Cecelia, Skytte, Anne-Bine, Zlowowcka-Perlowska, Elzbieta, Paolo Peterlongo, Bonanni, Bernardo, Ana Osorio, John L Hopper, Walker, L, Arnold, N, Morrison, Patrick, Hopper, JL, Yuan C. Ding, Arver, Brita, Ausems, Margreet, Brita Arver, Niederacher, D, Lubinski, Jan, Tihomirova, L., Kuchenbaecker, Karoline B, Ana Dutra Clarke, Gómez Garcia, Encarna B., Douglas F. Easton, Brewer, C., Mulligan, A.M., Osorio, A, Antonis C. Antoniou, Simone Heidemann, Esther M John, Mazoyer, S, Calender, A, Blanco, I, Rosa B. Barkardottir, Patrick J Morrison, Lee, A, Papi, Laura, GEMO Collaborators Study, Beattie, M.S., Lindblom, A., van Os, Theo A, van Rensburg, Elizabeth Jansen, van Os, Theo, Platte, Radka, Mieke Kriege, Spurdle, Amanda B, Antoniou, Antonis, Kirk, J, Ganz, Patricia A, Greene, Mark H., Ferrer, Sandra F, Gross, Jenny, Susan L Neuhausen, Yuan C Ding, Os, T.A., Mortemousque, Isabelle, Kirk, Judy, Ignacio Blanco, Hansen, T.V., Donaldson, A, Fredericksen, Z, Eeles, R., Hopper, J.L., Andrea Gehrig, Taru A Muranen, Godwin, AK, Nathanson, K, Buys, S., Peterlongo, Paolo, Kwong, A., Varon-Mateeva, R, Calender, A., Kruse, Torben A, Ros Eeles, Muy-Kheng, Tea, Terry, Mary, Kuchenbaecker, K. B., Montagna, M., Fiorica, J, Kruse, Torben A., Noralane M. Lindor, Gadzicki, D., Lindor, Noralane M, Loud, Jennifer, Pankratz, Vernon S, Davidson, R., Soucy, Penny, Raymonda Varon-Mateeva, D. E. Antoine Pauw, Brewer, Carole, Study Gemo Collaborators, Kruse, T.A., Judy Kirk, Sue Healey, Gerdes, Anne-Marie, Singer, Christian, Radka Platte, Engel, Christoph, Taru A. Muranen, Lindblom, Annika, Annika Lindblom, Torben A. Kruse, Ligtenberg, Marjolijn J., Schäfer, Dieter, Muranen, Taru, Xiaoqing Chen, Verhoef, S, Kirchhoff, T., Prieur, Fabienne, Hansen, Thomas V., Morrison, Patrick J., Godwin, Andrew K, Christian Sutter, Meindl, A, D. Geschwantler Kaulich, Muy Kheng Tea, Karlan, B.Y., Toland, Amanda E, Gómez Garcia, EB, Dieter Niederacher, Collée, J. Margriet, Wijnen, J., Ottini, Laura, Gross, J, Orland Diez, Os, T.A. van, Evans, Gareth; id_orcid, Isaacs, Claudine, Peterlongo, P, Jaworska, K., Fredericksen, Z., Jaworska, Katarzyna, Wijnen, J, Loman, Niklas,, Ozcelik, H, Rosa B Barkardottir, Manoukian, S., Rogers, Mark, Daniel Barrowdale, Gaudet, M., Hogervorst, Frans B, Adlard, J, Easton, Douglas F., Léoné, Mélanie, van Os , Theo, Fineberg, E, Byron, John, Collee, Margriet, Bernard Peissel, SWE-BRCA Study Collaborator, Caligo, MA, Lazaro, C, Muranen, TA, Ausems, M.G., Hanne EJ Meijers-Heijboer, Wang, X.S., Ferrer, S.F., Hogervorst, F.B., Domchek, S., Schmutzler, RK, Gomez Garcia, E.B., Anne Bine Skytte, Frenay, M, Lubinski, J., Kuchenbaecker, KB, Maria A. Caligo, Sutter, C., Anne-Marie Gerdes, Helmut Deissler, Finn C Nielsen, Garcia, E.B.G., Beattie, Mary S., Caligo, Maria A, Toland, Amanda E., Penny Soucy, Mulligan, Anna Marie, Mads Thomassen, Spurdle, Amanda, EMBRACE Study Collaborator, Dolcetti, Riccardo, Mazoyer, S., Deissler, H., Eeles, Ros, Gayther, Simon A, Tea, Muy-Kheng, Marjolijn J. Ligtenberg, van Os , Theo A, Gadzicki, D, Ferrer, Sandra, Sobol, H., Lesperance, B., Kirchhoff, T, Gayther, SA, Fergus J Couch, A. De Pauw, Cristina Oliani, Hansen, TV, Lespérance, Bernard, Frost, D., Vernon S Pankratz, Terry, MB, Hansen, Thomas V, Neuhausen, Susan, Hopper, John L., Hansen, TVO, van Os, TA, Hamann, U, Conxi Lazaro, Antoniou, AC, Rosemarie Davidson, Imyanitov, E., Dorfling, C.M., Isaacs, C., Davidson, R, Teulé, A, Hansen, T.V.O., Donaldson, Alan, Kaulich, Daphne, J Margriet Collée, Kaulich, Daphne, Geschwantler, Domchek, S, Mary S Beattie, Collée, JM, Offit, K, Adlard, Julian, John M. Esther, Frost, D, Cook, J., Schaefer, Dieter, Wang, XS, Ottini, L, Wang, Xianshu, Caligo, Maria, Peock, Susan, Karlan, BY, Elizabeth Jansen van Rensburg, Terry, MU, Jakubowska, Anna, Papi, L., Lee, A., Nielsen, FC, Paillerets, B. Bressac-de, John, EM, Embrace Hebon, Mulligan, AM, Kriege, M, Muranen, Taru A., Gayther, Simon, Teo, S.H., Mulligan, AU, Meijers-Heijboer, HE, Dieter Schafer, Rita K. Schmutzler, Wang, X, Sutter, C, Susan Domchek, Piedmonte, Marion, Ganz, P.A., Lalloo, F., Bove, Betsy, Alan Donaldson, E. Jansen Van Rensburg, Evans, D G, Kriege, Mieke, Ferrer, Sandra U., Schafer, D., Durda, K., Adlard, J., Loris Bernard, Encarna B. Gomez Garcia, Hamann, Ute, Miguel De La Hoya, Singer, Christian F, Norbert Arnold, Ausems, MG, Easton, Douglas, McGuffog, L., Peissel, Bernard, Tomas Kirchhoff, Blanco, I., Buys, S, Nathanson, Kate, Miron, A., Collee, M, Ganz, PA, Frost, Debra, Radice, Paolo, Arnold, Norbert, Rebbeck, T, Kast, Karin, Lubinski, J, Barkardottir, Rosa, Caldes, T., Frans B Hogervorst, Alexander Miron, Sinilnikova, OM, Meijers-Heijboer, Hanne E, Lisa Walker, Frans B. Hogervorst, Rosenquist, Richard,, Riccardo Dolcetti, Valle, J. Del, Chris Jacobs, Fiorica, J., Ozcelik, H., Trinidad Caldes, Stoppa-Lyonnet, D., Léoné, M, Ferrer, Sandra,, K. Investigators, Dorkins, H, Cohn, David, Kuchenbaecker, K.B., Wijnen, J. van, van Os, Theo A., Hansen, Thomas VO, Katarzyna Durda, Morrison, PJ, Wijnen, Juul, David Cohn, Andrés, Raquel, Valle, J Del, Marc Frenay, Karin Kast, Huw Dorkins, Caldes, T, Oosterwijk, Jan, Heidemann, Simone, Hogervorst, FB, Margreet Gem Ausems, Stoppa-Lyonnet, D, Ligtenberg, M.J., Peterlongo, P., Garcia, Encarna B. Gomez, John, Esther, Greene, Mark H, Daphne Kaulich, Teule, A., Olah, E., Gehrig, Andrea, Montagna, M, Ligtenberg, Marjolijn, Beattie, Mary, Anneliese Fink-Retter, Beattie, MS, Vijai Joseph, Kaulich, DG, Kaulich, DU, E. Study, Jackie Cook, Mulligan, Anna, Marie, Encarna B Gómez Garcia, Neuhausen, Susan L, Terry, Mary, Beth, Karlsson, P., Lee, Andrew Roger, Barbara Wappenschmidt, Meindl, Alfons, Terry, Mary,, Neuhausen, S.L., Del Valle, J, van Os, T.A., Lazaro, Conxi, Olah, E, Durda, Katarzyna, Alain Calender, Evgeny Imyanitov, Anna Marie Mulligan, Soucy, P., E. Zlowocka Perlowska, Toland, Amanda, Złowowcka-Perłowska, Elżbieta, Isabelle Mortemousque, Durda, K, Dorkins, Huw, Healey, S, Chen, Xiaoqing, Couch, Fergus, Rosenquist, Richard, Research H. Facility, EMBRACE, Dorothea Gadzicki, Preisler-Adams, S., Glendon, Gord, Karoline B. Kuchenbaecker, Toland, A.E., Karlan, Beth, Greene, M.H., Kaulich, Daphne U., Nevanlinna, H., Hoya, M. de la, Elżbieta Złowowcka-Perłowska, McGuffog, Lesley, Lazaro, C (Conxi), Hilmi Ozcelik, Karoline B Kuchenbaecker, Melanie Leone, Złowowcka-Perłowska, E, Ana Dutra-Clarke, Muranen, Taru A, Lee, Andrew, Jensen, UB, Houdayer, Claude, Raquel Andres, Meijers-Heijboer, H.E., Mazoyer, Sylvie, Christian F. Singer, Olga M Sinilnikova, Hopper, John, Schmutzler, Rita, Platte, R, Antoniou, A.C., Claudine Isaacs, Ellis, Steve D, Terry, Mary U, Singer, CF, Ding, Yuan C., Blanco, Ignacio, Mulligan, Anna,, Oosterwijk, JC, Zlowowcka-Perłowska, Elżbieta, Andrulis, IL, HEBON Study Collaborator, Pankratz, VS, Lesley Mcguffog, Loud, J.T., Chen, XQ, Goldgar, D., Collée, J M, Ausems, Margreet GEM, Ava Kwong, Byron, J., Siranoush Manoukian, Nevanlinna, H, Terry, Mary B, Marjolijn J Ligtenberg, Goldgar, D, Mark H. Greene, Sylvie Mazoyer, Fink-Retter, A., Meijers-Heijboer, Hanne E J, Hanne E. J. Meijers Heijboer, Dorfling, CM, Loman, N., Zaffaroni, Daniela, Preisler-Adams, Sabine, Pankratz, V.S., Chen, X., Heidemann, S, Simard, J., Sobol, Hagay, Easton, D.F., Kwong, A, Sabine Preisler-Adams, Per Karlsson, Fiorica, James, Bernard, L, Godwin, Andrew K., Mary Beth Terry, Radice, P, Niklas Loman, Chenevix-Trench, G., Daly, Mary, V. Joseph, Ausems, MGEM, Sinilnikova, O.M., Terry, Mary Beth, Glendon, G, Ding, Y.C., Ausems, Margreet G. E. M., Elzbieta Złowowcka Perłowska, Muranen, T.A., Hansen, Thomas V. O., Lazaro, C., kConFab Investigators, Buecher, B, Imyanitov, E, Joseph, Vijai, Christoph Engel, van Rensburg, Elizabeth, Jansen, Loud, Jennifer T., Bernard, Loris, Betsy Bove, Ausems, M.G.E.M., Couch, Fergus J, Paterson, J., Garcia, EBG, van Rensburg, EU, Andrulis, Irene L, Barkardottir, Rosa B., Buecher, B., Ganz, Patricia, Olga M. Sinilnikova, Wappenschmidt, B, Zachary Fredericksen, Elena Fineberg, Niederacher, D., Simon A. Gayther, Douglas, F, Hurteau, J, Mia Gaudet, Kunle Odunsi, Cancer Study S. B. Swedish Breast, Carole Brewer, de Pauw, Antoine, Greene, MH, Karlan, Beth Y, Piedmonte, M, Laima Tihomirova, van Rensburg, EJ, Georgia Chenevix-Trench, Osorio, Ana, Bressac-de Paillerets, B., Offit, Kenneth, Nielsen, Finn, van Rensburg, Elizabeth,, Debra Frost, Piedmonte, M., et al., Mercedes Duran, Buecher, Bruno, Jensen, Uffe B, Southey, Melissa, Houdayer, C., Barrowdale, D, Jaworska, K, Spurdle, Amanda B., Kast, K., Nielsen, Finn C, Evans, D Gareth, Bonanni, B, Spurdle, AB, Ligtenberg, Marjolijn J, Greene, Mark, Soucy, P, Southey, M, Hagay Sobol, Evans, DG, Bove, B, Prieur, F, Rebbeck, Tim, Melissa Southey, Cecelia M Dorfling, Nina Ditsch, Frenay, M., Neuhausen, Susan L., Miron, A, Platte, R., Bove, B., Fink-Retter, Anneliese, Fiebig, B, Byron, J, Hodgson, Shirley, Schaefer, D, Jean Hurteau, Shirley Hodgson, Kate Nathanson, de Pauw, A, Oliani, C, Fineberg, E., Antoniou, Antonis C, Kaulich, Daphne,, Trevor Cole, Rogers, M.T., Gayther, Simon A., Paterson, Joan, Andrew K Godwin, Amanda E. Toland, Britta Fiebig, Zaffaroni, D., Joan Paterson, Ditsch, N, Oosterwijk, Jan C., Andres, R., Joseph, V, Fiebig, Britta, Bressac- de Paillerets, Brigitte, Thomassen, Mads, Meijers-Heijboer, HEJ, Soo-Hwang Teo, GEMO Study Collaborator, Prieur, F., Kruse, TA, Tihomirova, Laima, Preisler-Adams, S, Richard Rosenquist, Ferrer, Sandra, Fert, Daphne Geschwantler Kaulich, Rebbeck, T., Leone, M., Ellis, Steve, Thomas V. O. Hansen, Kenneth Offit, Jan Lubinski, Evans, D. Gareth, John Byron, Noralane M Lindor, Walker, Lisa, Marion Piedmonte, Ellis, Steve D., Jonathan Beesley, Caron, O., Heidemann, S., Diez, O, Ditsch, N., Easton, Douglas F, Jacobs, C, Steve D. Ellis, Hogervorst, Frans B., Theo A van Os, Christian F Singer, Morrison, P.J., Niederacher, Dieter, Chenevix-Trench, G, Teo, Soo-Hwang, Mary S. Beattie, Arver, B., Cohn, D., Mark T Rogers, Del Valle, J., Jensen, Uffe B., Lund University., Dolcetti, R, van Wijnen, J (Juul), Gehrig, A, Teulé, Alex, D. Gareth Evans, Dominique Stoppa Lyonnet, Oosterwijk, J.C., Pankratz, Vernon S., Geschwantler Kaulich, Daphne, Couch, FJ, Offit, K., Evans, D.G., Jensen, Uffe, Meijers-Heijboer, Hanne EJ, Eeles, R, Nevanlinna, Heli, Schäfer, D, Cook, Jackie, Ditsch, Nina, Healey, S., John L. Hopper, Jacques Simard, Ligtenberg, MJ, Hodgson, S., Benítez, J, van Rensburg, Elizabeth U., Engel, C, van Rensburg, Elizabeth J, Gehrig, A., Durán, M, Meijers-Heijboer, Hanne, Peissel, B., Simard, Jacques, Jakubowska, A, Hogervorst, Frans, Gayther, S.A., Glendon, G., Uffe B. Jensen, Caron, O (Olivier), J. Del Valle, Ding, Yuan, Beesley, J, Odunsi, Kunle, Terry, Mary U., Odunsi, K., Jacobs, Chris, Valle, J D, van Rensburg, Elizabeth U, Sabine Preisler Adams, Amanda E Toland, Cecelia M. Dorfling, Terry, M.U., Diez, Orland, Couch, Fergus J., Mulligan, Anna U., Benítez, Javier, Lindor, N.M., Sandra Ferrer, Sandra Fert Ferrer, Mulligan, Anna M, Joseph Vijai, Dutra-Clarke, A., Douglas, Fiona, Beattie, Mary S, Mulligan, Anna U, Couch, F.J., Loud, Jennifer T, Paterson, J, Thomas VO Hansen, Daly, M., Jenny Gross, Chen, X, Ellis, S.D., Montagna, Marco, Hamann, U., Patrick J. Morrison, Teo, SH, Ding, Yuan C, Steve D Ellis, Toland, AE, Douglas F Easton, Ferrer, Sandra Fert, Ausems, Margreet G E M, Saundra Buys, Fabienne Prieur, Kriege, M., Gómez Garcia, Encarna B, Irene L Andrulis, Mulligan, Anna, Karlan, Beth Y., A. Van, Laura Ottini, Kwong, Ava, Torben A Kruse, Manoukian, S, Laura Papi, Spurdle, A.B., Collée, J Margriet, Gross, J., Benitez, J., Caligo, Maria A., Andrulis, Irene, Gaudet, M, Neuhausen, SL, Simard, J, Andrés, R, Skytte, AB, James Fiorica, Kuchenbaecker, Karoline, Isaacs, C, Mortemousque, I, Mary Terry, Hurteau, Jean, Kruse, Torben, Ding, YC, Fiona Douglas, Brewer, C, null null, Mortemousque, I., Olah, Edith, Zlowowcka-Perlowska, E., Bressac-de Paillerets, B, Lindor, NM, John Em, CIMBA Study Collaborator, Sinilnikova, Olga M, Caron, Olivier, Andrulis, Irene L., Arnold, N., Gerdes, A-M, Thomassen, M, Soo Hwang Teo, Kuchenbaecker, Karoline B., Harbst, K., Juul Wijnen, Uffe B Jensen, Davidson, Rosemarie, Tea, M-K, David Goldgar, Bernardo Bonanni, Sinilnikova, Olga Muno, Hansen, Thomas, Jennifer T. Loud, Ganz, Patricia A., John, E.M., van Rensburg, Elizabeth, Easton, DF, Fiebig, B., Dorfling, Cecelia M, Harbst, Katja, Terry, M.B., Piedmonte, M., Gaudet, Mia, Ottini, L., Teo, S-H, Duran, M., Susan Peock, Kaulich, Daphne G, Barkardottir, RB, Zlowowcka-Perlowska, E, Nathanson, K., Singer, C.F., Simon A Gayther, Dolcetti, R., Kaulich, Daphne U, Senno Verhoef, John, Esther M., Chenevix-Trench, Georgia, Elizabeth Van Rensburg, J Del Valle, Papi, L, Skytte, A-B, Kaulich, D.G., Fink-Retter, A, Lalloo, Fiona, Godwin, A.K., Alex Teule, Ute Hamann, Lindor, Noralane, Marco Montagna, Valle, JD, Pauw, A. de, John, Esther M, Antoniou, Antonis C., Verhoef, S., Katarzyna Jaworska, Varon-Mateeva, R., Barrowdale, Daniel, Andrulis, I.L., Caligo, M.A., Oliani, C., Swe Brca Cimba, Sutter, Christian, Meijers-Heijboer, Hanne EJ., Rosenquist, R., Karlsson, P, D Gareth Evans, Frenay, Marc, Anna Mulligan, Claude Houdayer, Schmutzler, R.K., Anneliese Fink Retter, Brigitte Bressac De Paillerets, Cook, J.L., Cole, T., Lalloo, F, Anna Jakubowska, Bressac-de Paillerets, Brigitte, Fiona Lalloo, Jacobs, C., Katja Harbst, Karlsson, Per W., Cohn, D, Joseph, V., Collee, J.M., Sinilnikova, Olga M., Bonanni, B., de Pauw, A., Fineberg, Elena, Amanda B. Spurdle, Healey, Sue, Daly, M, Antoniou, A. C., Chen, X.Q., Rita K Schmutzler, Rogers, MT, Patricia A Ganz, Beesley, J., Calender, Alain, Finn C. Nielsen, Skytte, A.B., Gadzicki, Dorothea, Loman, N, Cook, J, Wappenschmidt, B., Beth Y. Karlan, Dorkins, H., Kaulich, D.U., Mary Daly, Hopper, John L, Domchek, Susan, Lindblom, A, Tim Rebbeck, Vernon S. Pankratz, Godwin, Andrew, Oosterwijk, Jan C, de la Hoya, M, Nielsen, F.C., Meijers-Heijboer, Hanne E. J., Thomassen, M., Deissler, Helmut, Kirchhoff, Tomas, Barkardottir, R.B., Rogers, Mark T., Daniela Zaffaroni, Harbst, Katja,, Paolo Radice, Gómez Garcia, Encarna, Buys, Saundra, Ligtenberg, M.J.L., Morrison, Patrick J, J. Margriet Collee, Jan C Oosterwijk, Ausems, Margreet G, Tea, MK, Peterlongo, Paulo, Miron, Alexander, Fergus J. Couch, Schmutzler, Rita K., Ferrer, Sandra U, Terry Mu, Singer, Christian F., Peock, S., Irene L. Andrulis, Georgia Chenevix Trench, Tea, M.K., Bernard, L., Terry Mb, Houdayer, C, Durán, Mercedes, Southey, M., Peock, S, Goldgar, David, Zaffaroni, D, Hodgson, S, Cole, Trevor, Imyanitov, Evgeny, Nielsen, Finn C., Rensburg, E.J. van, Jensen, U.B., Ferrer, SF, Jansen van Rensburg, Elizabeth, Bernard Lesperance, Gerdes, A.M., Oliani, Cristina, Arver, B, Deissler, H, HEBON, Ellis, SD, Karlsson, Per, Julian Adlard, Beth Y Karlan, Manoukian, Siranoush, Meijers-Heijboer, H.E.J., Javier Benitez, Osorio, A., Collee, M., Radice, P., Alfons Meindl, Andrew Lee, Mark T. Rogers, Kirk, J., Jakubowska, A., Gerdes, AM, Schmutzler, Rita K, Wappenschmidt, Barbara, Ferrer, SU, Thomassen, Marga, Rogers, Mark T, Caldes, Trinidad, Amanda B Spurdle, Lindor, Noralane M., Sinilnikova, Olga, Gord Glendon, Study G. Collaborators, Peissel, B, Dutra-Clarke, A, Edith Olah, McGuffog, L, Kaulich, Daphne Geschwantler, Loud, JT, Xianshu Wang, Brigitte Bressac- de Paillerets, Anne-Bine Skytte, Ferrer, S.U., Antonis C Antoniou, Rosenquist, R, Caron, O, Loman, Niklas, Sobol, H, Cole, T, Olivier Caron, Antoine de Pauw, Fredericksen, Zachary, Dominique Stoppa-Lyonnet, Meijers-Heijboer, E.J., Susan L. Neuhausen +999 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
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