Results 81 to 90 of about 192,885 (309)
Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen +9 morewiley +1 more sourceMammographic tumour appearance and triple-negative breast cancer associated with long-term prognosis of breast cancer death: A Swedish Cohort Study
, 2017 Background: Numerous studies have paid attention to the role of the triple-negative marker in the prognosis of breast cancer, but very few studies have combined mammographic phenotypes with the triple-negative marker to assess their relevance to the long-郭文宏;陳秀熙, Tsau, Huei-Shian;Yen, Amy Ming-Fang;Fann, Jean Ching-Yuan;Wu, Wendy Yi-Ying;Yu, Cheng-Ping;Chen, Sam Li-Sheng;Chiu, Sherry Yueh-Hsia;Tabar, Laszlo;Kuo, Wen-Hung;Chen, Hsiu-Hsi;Chang, King-Jen +1 morecore +1 more sourceESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou +12 morewiley +1 more sourceA novel prognostic two-gene signature for triple negative breast cancer
, 2020 The absence of a robust risk stratification tool for triple negative breast cancer (TNBC) underlies imprecise and non-selective treatment of these patients with cytotoxic chemotherapy.Alsaleem, MA, Elemento, O, Toss, MS, Joseph, C, Rakha, Emad, Alsaleem, Mansour A, Raafat, S, Mongan, NP, Ball, G, Ellis, Ian O, Davis, Melissa, Elemento, Olivier, Bhattarai, S, Green, Andrew, Ball, Graham, Aleskandarany, Mohammed, Rida, PCG, Rida, Padmashree C G, Ogden, A, Joseph, Chitra, Green, A, Bhattarai, Shristi, Rakha, E, Toss, Michael S, Aneja, Ritu, Ogden, Angela, Ellis, IO, Aleskandarany, M, Mongan, Nigel P., Davis, M, Raafat, Sara, Khani, F, Aneja, R, Khani, Francesca +33 morecore +1 more sourceCritical research gaps and translational priorities for the successful prevention and treatment of breast cancer [PDF]
, 2013 IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating ...Gee, Julia M. W., Hulbert-Williams, Nicholas J., Anderson, Annie, Martin, S.G., Stingl, J., Key, Timothy, Hunter, MS, Walker, Rosemary, Martin, SG, Stephen Hiscox, O’Connor, Rosemary, Smalley, Matthew J., Aboagye, Eric, Williams, K.J., Christine J Watson, Annie S Anderson, Robert B Clarke, Bundred, Nigel, Tutt, Andrew N J, Jo Armes, Evans, D, Brown, N.J., Smalley, Matthew J, Clarke, R.B., Charles H. Streuli (7669838), Eric O Aboagye, Bundred, Nigel J., Groves, Ashley, Aboagye, Eric O., John M. Saxton (7244180), Watson, Christine, Watson, C.J., Montserrat Garcia-Closas (89866), Palmieri, C., Anderson, Annie S.; id_orcid, Miller, WR, Moss, SM, Evans, D., Burchell, JM, Nicola J. Brown (7596590), John F. Marshall (7957925), John M Saxton, Amanda J Harvey, Eccles, Suzanne A., Flanagan, James, Bharat Jasani, Fedor Berditchevski, Pharoah, Paul D.P., Marshall, John F., Stingl, John, Peter Schmid, Macdougall, J.E., Cliona C. Kirwan (3934682), Duffy, Stephen W, Leach, M.O., Stein, R., Eccles, Suzanne A, Hunter, Myra, Miller, William R., Howell, Anthony, Stewart G Martin, Edwards, Dylan R., Kunkler, IH, Silva, IDOSS, Miles, D.W., Paul D P Pharoah, Ian H. Kunkler (7957919), Young, L.S., Evans, DG, Galina Velikova, Goh, V., Kong, A., Jasani, Bharat, Watson, CJ, Paul DP Pharoah (7957952), Gee, JM, Streuli, CH, Berditchevski, F., Walker, R.A., Nick Hulbert-Williams, Groves, Ashley M., Moss, Sue, Sahai, E, Jones, LJ, Goh, Vicky, Leach, Martin O., Charlotte E Coles, Gary JR Cook, Berditchevski, F, Hennessy, Bryan T., Carroll, J.S., Gee, Julia MW, Jennifer E Macdougall, Armes, Jo, Garcia-Closas, M., Aboagye, Eric O, Martin, L.A., O'Connor, J.P.B., Anthony Howell (23576), Key, Timothy J, Mullan, P, Kaye J Williams, Harvie, Michelle N., Brown, NJ, Miles, David, Harvey, AJ, Rakha, Emad A, Isabel dos Santos Silva, Thompson, Alastair M., Palmieri, C, Miller, W.R., David W Miles, Velikova, Galina, Moss, S.M., Bryant, Helen E, Cox, A, Jo Armes (3480905), Reed, E., Eccles, Diana M., Marshall, JF, Cook, Gary J. R., William R Miller, Pharoah, P.D.P., Anderson, Annie S, Fedor Berditchevski (3827920), Duffy, SW, Young, Leonie, Nicola J Brown, Martin, Stewart, Hubbard, G., Saxton, John M., Dekker, Lodewijk, Brown, Nicola, Bundred, N.J., Martin, LA, Cox, Angela, Armes, J., William M. Gallagher (265756), Charlotte E. Coles (7688222), Andrew N J Tutt, Alastair M Thompson, Aboagye, EO, Simak Ali, Paul Mullan (6534653), Jones, Louise, Rosemary O'Connor (94873), Coles, Charlotte E, Evans, D. Gareth, Burchell, Joy, Jeremy P. Blaydes (7957853), Hiscox, Stephen, Deborah F. Fenlon (7957892), Robert Stein, Speirs, Valerie, Simon P. Robinson (7957958), Hulbert-Williams, N., Joy M Burchell, Claire Foster (768031), Julia MW Gee (7957898), Julia M W Gee, D Gareth Evans (7957889), Michelle Harvie (3455429), Gee, Julia M.W., Easton, Douglas F, Gescher, A.J., Jasani, B., Key, Timothy J., Bryan T Hennessy, Smalley, Matthew John, O'Connor, JP, Williams, Kaye J, Cook, Gary, Bryant, Helen E., Eccles, DM, O’Connor, JPB, Schmid, P., David W. Miles (7957937), Rakha, Emad A., Robinson, Simon P., Sue M Moss, Blaydes, J.P., John F Marshall, Jason S Carroll, Langdon, Simon P, Cook, Gary Jr, Fenlon, D.F., Macdougall, Jennifer E., Sue M. Moss (7957943), Douglas F. Easton (7957880), Suzanne A Eccles, Evans, D.G., Angela Cox (76913), Harvey, A.J., Rosemary A Walker, Howell, A., Stein, Robert, Evans, D.Gareth, Martin, Stewart G., Edwards, Dylan, David J. Mann (2820133), O'Connor, R, Jennifer E. Macdougall (7957934), Hennessy, Bryan T, Edwards, Joanne, O'Connor, James P. B., Carroll, Jason, Anderson, A.S., Gill Hubbard (3403994), Robinson, SP, Groves, Ashley M, Hulbert-Williams, N, Watson, Christine J, Amanda J. Harvey (7957904), Kirwan, Cliona C.; id_orcid, Speirs, V, Campbell, AM, Cook, Gary J., Bryant, Helen, Coles, Charlotte E., Fenlon, Deborah F., Martin, Lesley, Blaydes, Jeremy P, Martin O Leach, Erik Sahai, Ashley M. Groves (7957901), Williams, Kaye J., Langdon, Simon P., O’Connor, James P., Bryant, HE, Edwards, J, Blaydes, JP, Emad A Rakha, Morris, Joanna R., Groves, A.M., Louise J Jones, Thompson, AM, Easton, Douglas F., Dekker, LV, Jasani, B, Harvey, Amanda J., Howell, S.J., Anna M Campbell, Saxton, JM, Vicky Goh (577982), Leach, Martin O, Stephen W Duffy, Tutt, Andrew NJ, Ali, S., Blaydes, Jeremy P., Howell, Sacha J.; id_orcid, Louise J. Jones (7957916), Harvie, Michelle, Clarke, Robert B, Lesley Ann Martin, Garcia-Closas, Montserrat, Kunkler, Ian H., Angela Cox, Leach, MO, Fenlon, Deborah, dos Santos Silva, Isabel, Leonie Young (7895759), Pharoah, Paul D. P., Harvey, Amanda, Rakha, Emad, Jones, L.J., Morris, JR, Campbell, Anna, Kunkler, Ian H, Reed, Elizabeth, Douglas F Easton, Deborah F Fenlon, Berditchevski, Fedor, Coles, C.E., Gallagher, W.M., Carlo Palmieri (681317), Howell, A, Brennan, K, Rakha, EA, Rosemary A. Walker (7580297), Jeremy P Blaydes, Duffy, Stephen, Matthew J. Smalley (7957961), Sacha J Howell, Gescher, Andy, Macdougall, JE, Elizabeth Reed (3138513), Natrajan, R., O'Connor, R., Montserrat Garcia-Closas, Bundred, Nigel J, Nicola J. Curtin (351064), Holen, Ingunn, Carroll, JS, Goh, Vicky; id_orcid, Alastair M. Thompson (7957970), Bryan Hennessy (7898999), Cook, GJR, Brown, Nicola J, Reed, E, Kirwan, CC, Hunter, Myra S., Walker, Rosemary A., Robinson, S.P., Michelle Harvie, Duffy, S.W., Saxton, John, Ingunn Holen, Suzanne A Eccles (7957850), Brennan, K., Gallagher, William, Rosemary O’Connor, Isabel Dos Santos Silva (7957874), John Stingl, Andy J. Gescher (7671179), Joanna R Morris, Annie S. Anderson (6298127), Morris, Jo; id_orcid, Langdon, Simon, Rachel Natrajan (7957946), Ali, S, Hubbard, Gill, Vicky Goh, Sacha J. Howell (7957907), Smalley, M.J., Holen, I, Sahai, E., Helen E Bryant, Edwards, Dylan R, Edwards, D.R., Cliona C Kirwan, Stein, R, Simon P Robinson, Timothy J. Key (7755380), James M Flanagan, Martin, Lesley Ann, Nick Hulbert-Williams (7957910), Morris, Joanna, Brown, Nicola J., Silva, Isabel dos Santos, Nicola J Curtin, Foster, Claire, Kaye J. Williams (7957967), Paul Mullan, Nigel J. Bundred (7957859), Curtin, NJ, Gee, Julia M W, Eccles, Diana, Campbell, Anna M, Streuli, C.H., Tutt, Andrew, Fenlon, Deborah F, Clarke, Robert B., Mullan, P., Silva, IDS, Gee, J.M.W., Morris, J.R., Valerie Speirs (1679), O'Connor, James, Cook, Gary J R, O’Connor, James P.B., Campbell, A.M., Easton, DF, Watson, Christine J., Goh, V, Bryant, H.E., Eric O. Aboagye (309960), Marshall, J.F., Howell, Anthony; id_orcid, Burchell, Joy M, Tutt, AN, Easton, Douglas, Tutt, A.N.J., Jones, Louise J, Streuli, Charles H, Hiscox, S., Schmid, Peter, Joanne Edwards (589089), Gallagher, William M, Stingl, J, Dekker, L.V., Claire Foster, Robinson, Simon P, Curtin, Nicola, Gee, Julia, Tutt, ANJ, Howell, Sacha, Saxton, J.M., Foster, C., Miles, David W, Erik Sahai (829065), Thompson, A.M., Mullan, Paul, Kirwan, Cliona C, James PB O’Connor, Mann, DJ, Rakha, E.A., Pharoah, Paul DP, Helen E. Bryant (7957856), Burchell, Joy M., Natrajan, R, Harvie, M, Carlo Palmieri, Gescher, Andy J, Macdougall, Jennifer E, Hubbard, G, Hulbert-Williams, Nick, Mann, David, Clarke, Robert, Cook, Gary J.R., Anthony Howell, Dekker, Lodewijk V, Hennessy, B.T., Young, Leonie S., Joy M. Burchell (7957862), Foster, C, Key, T.J., Moss, Sue M, Williams, Kaye, Peter Schmid (81036), D Gareth Evans, Hubbard, Gill; id_orcid, Ashley M Groves, Curtin, Nicola J., Gescher, AJ, Joanna R. Morris (7957940), Clarke, RB, Streuli, Charles, Palmieri, Carlo, Martin O. Leach (454145), Mann, David J., Ingunn Holen (3637012), Marshall, John, Simon P Langdon, Bundred, NJ, Gill Hubbard, Keith Brennan (1659), Young, LS, Timothy J Key, Kong, A, dos Santos Silva, I, Eccles, SA, Marshall, John F, Miller, William, Fenlon, DF, Charles H Streuli, Langdon, SP, Pharoah, Paul, Hunter, M.S., Streuli, Charles H., Matthew J Smalley, Smalley, MJ, Kirwan, Cliona C., Christine J. Watson (7585901), Gescher, Andy J., Tutt, Andrew N. J., Kunkler, Ian, Robinson, Simon, Keith Brennan, O’Connor, R, Eccles, S.A., Cook, G.J.R., Valerie Speirs, Kong, Hee, Curtin, N.J., Dylan R. Edwards (7957886), Hiscox, S, Edwards, DR, Gary Jr Cook (7957868), Nigel J Bundred, Eccles, Diana M, James M. Flanagan (7957895), Leach, Martin, Speirs, V., James PB O'Connor (7957949), Howell, Sacha J., Joanne Edwards, Coles, Charlotte, Emad A. Rakha (7957955), Key, TJ, Carroll, Jason S, Rachel Natrajan, Stephen W. Duffy (7957877), Walker, RA, Kong, Anthony, Eccles, Suzanne, Miles, DW, Gallagher, William M., Curtin, Nicola J, Stewart G. Martin (7957931), Ali, Simak, Jones, Louise J., Bharat Jasani (4954081), Howell, Sacha J, Mann, David J, Valikova, G., Dylan R Edwards, Macdougall, Jennifer, Blaydes, Jeremy, Miles, David W., Miller, William R, Burchell, Joy M; id_orcid, Kunkler, I.H., Anderson, AS, Armes, J, Groves, AM, Diana M. Eccles (7957883), Mann, D.J., Andy J Gescher, Flanagan, James M., O'Connor, James P B, Eccles, D.M., Garcia-Closas, M, Flanagan, J.M., Kirwan, C.C., Pharoah, Paul D P, Leonie S Young, Ian H Kunkler, Anderson, Annie S., Hennessy, Bryan, dos Santos Silva, I., Deborah Fenlon, Myra S Hunter, O'Connor, JPB, Galina Velikova (3069645), Hiscox, Stephen Edward, Carroll, Jason S., David J Mann, Holen, I., Campbell, Anna M., Flanagan, JM, Aboagye, E.O., Pharoah, PD, Velikova, G, Harvey, Amanda J, Martin, Stewart G, Sahai, Erik, Martin, L, Stephen Hiscox (361114), Cook, Gary JR; id_orcid, Coles, CE, Williams, KJ, Silva, IS, Morris, Joanna R, Lodewijk V Dekker, Hennessy, BT, Thompson, Alastair M, Simak Ali (12335), Pharoah, PDP, Saxton, John M, Cook, GJ, Evans, D. G., Andrew NJ Tutt (7957964), Simon P. Langdon (7957922), Dekker, Lodewijk V., Anna M. Campbell (7957865), Moss, Sue M., Gee, JMW, Lesley A. Martin (7957928), Harvie, M., Clarke, Robert; id_orcid, O'Connor, Rosemary, Natrajan, Rachel, Cox, A., Edwards, J., Young, Leonie S, Anthony Kong, Smalley, Matthew, Diana M Eccles, William M Gallagher, Elizabeth Reed, Schmid, P, Brennan, Keith, Langdon, S.P., Duffy, Stephen W., Easton, D.F., Walker, Rosemary A, Kirwan, Cliona, Flanagan, James M, O'Connor, James Pb, Gallagher, WM, Martin, Lesley A., Anthony Kong (94738), Gee, Julia Margaret Wendy, Howell, SJ, Hunter, Myra S, Myra S. Hunter (7957913), Lodewijk V V. Dekker (7957871), William R. Miller (1372755), Robert Stein (1704328), John Stingl (444979), Jason S. Carroll (7901276), Burchell, J.M., Robert B. Clarke (7948805) +592 morecore +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more source
