Results 71 to 80 of about 6,967,236 (252)

The overview of modern approaches in treatment of triple negative breast cancer

Исследования и практика в медицине, 2020
By far the most aggressive subtype of breast cancer is triple negative cancer. The purpose of this review is to analyze current ideas about the pathogenesis, clinical characteristics of different subtypes of triple negative breast cancer, the nature of ...
A. A. Kharitonova, I. A. Smirnova, M. V. Kiseleva   +2 more
doaj   +1 more source

Preventative therapies for healthy women at high risk of breast cancer [PDF]

, 2014
Ivana Sestak Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UKAbstract: Tamoxifen has been shown to reduce the risk of developing estrogen receptor (ER)-positive ...
Sestak I, Sestak, I
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A chromatin-informed transcriptional regulatory framework to stratify patients and guide therapy selection in triple-negative breast cancer

Nature Communications
Triple-negative breast cancer is an aggressive and heterogeneous breast cancer subtype with few effective targeted therapies and frequent resistance to chemotherapy.
Shalini Bahl, Nergiz Dogan-Artun, Julia Nguyen, Hassan Mahmoud, Wail Ba-alawi, Seyed Ali Madani Tonekaboni, Komaldeep Kaur Kang, Meghan McGuire, Chantal Tobin, Jennifer Silvester, Paul Savage, Lucie Cressot, Ankita Nand, Guanqiao Feng, Paul Guilhamon, Arvind Singh Mer, Christopher Arlidge, Mitchell J. Elliott, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien   +21 more
doaj   +1 more source

Molecular Classification of Triple-Negative Breast Cancer [PDF]

, 2017
Tumor heterogeneity of triple-negative breast cancer (TNBC) has been the main barrier in conquering breast cancer. To dissect the molecular diversity of TNBC and discover therapeutic targets for TNBC, the molecular classification of TNBC is a prioritized
정준, 안성귀
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Pathological Features of Breast Cancer seen in Northwestern Tanzania: A Nine Years Retrospective Study. [PDF]

, 2011
Breast cancer is more common in Western Countries compared to African populations. However in African population, it appears that the disease tends to be more aggressive and occurring at a relatively young age at the time of presentation. The aim of this
Chalya Philipo L, Jackson Kahima J, Jackson, Kahima J, Rambau Peter F, Chalya, Philipo L, Manyama, Mange M, Mange M Manyama, Manyama Mange M, Peter F Rambau, Philipo L Chalya, Rambau, Peter F, Kahima J Jackson   +11 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Factors Associated with Breast Cancer Risk According to Tumor Subtypes: Triple Negative Breast Cancer vs. NON-Triple Negative Breast Cancer Among Women in Karachi, Pakistan

Pakistan Armed Forces Medical Journal
Objective: To evaluate risk factors associated with triple negative breast cancer among women in Karachi Pakistan Study Design: Multicenter hospital-based case control study Place and Duration of Study: Aga Khan University Hospital and Karachi ...
Uzma Shamsi, Azra Shamsi, Shaeryar Usman   +2 more
doaj   +1 more source