Results 71 to 80 of about 406,491 (336)
Acinic cell carcinoma of the breast: A comprehensive review
Breast, 2022 Acinic cell carcinoma of the breast is a rare special subtype of breast cancer in the category of salivary gland-type tumors. It is morphologically similar to acinic cell carcinomas of salivary glands and pancreas and has a triple-negative phenotype ...
Azra Ajkunic +6 more
doaj +1 more source
Parity, hormones and breast cancer subtypes - results from a large nested case-control study in a national screening program. [PDF]
, 2016 BACKGROUND: Breast cancer comprises several molecular subtypes with different prognoses and possibly different etiology. Reproductive and hormonal factors are associated with breast cancer overall, and with luminal subtypes, but the associations with ...
Dos-Santos-Silva, Isabel +5 more
core +2 more sources
The Challenge of Triple Negative Breast Cancers [PDF]
Indian Journal of Clinical Biochemistry, 2014 The role of hormones (estrogen) in breast carcinogenesis was recognized even in the nineteenth century. About 70 % of breast cancers express estrogen receptors (ER), and ER positive tumors proliferate in response to estrogen. ER positive tumors had better prognosis compared to ER negative ones.
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Tumor Biology, 2017 Breast cancer has attracted substantial attention as one of the major cancers causing death in women. It is crucial to find potential biomarkers of prognostic value in breast cancer. In this study, the expression pattern of anterior gradient protein 2 in
Jilong Guo, Guohua Gong, Bin Zhang
doaj +1 more source
Biomedicines, 2021 Breast cancer is the most frequent cancer and the second leading cause of death among women. Triple-negative breast cancer is the most aggressive subtype of breast cancer and is characterized by the absence of hormone receptors and human epithelial ...
Vanessa Castelli +10 more
doaj +1 more source
Current Treatment Landscape for Early Triple-Negative Breast Cancer (TNBC)
Journal of Clinical Medicine, 2023 Triple-negative breast cancer (TNBC) accounts for 15–20% of all breast cancers and is characterized by an aggressive nature and a high rate of recurrence despite neoadjuvant and adjuvant chemotherapy. Although novel agents are constantly being introduced
Jieun Lee
semanticscholar +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer [PDF]
, 2014 FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis.
Abdel-Fatah +59 more
core +2 more sources
The Cancer Journal, 2021 Abstract Triple-negative breast cancer (TNBC) is pathologically defined by lack of expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 amplification and portends an aggressive clinical course with worse outcomes compared with other breast cancers.
Sara E, Nunnery +2 more
openaire +3 more sources