Results 71 to 80 of about 192,885 (309)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà +11 morewiley +1 more sourceFilamin A in triple negative breast cancer
SteroidsTriple-negative breast cancer is a rare but highly heterogeneous breast cancer subtype with a limited choice of specific treatments. Chemotherapy remains the only efficient treatment, but its side effects and the development of resistance consolidate the urgent need to discover new targets.Pia Giovannelli, Marzia Di Donato, Fabrizio Licitra, Emilia Sabbatino, Viviana Tutino, Gabriella Castoria, Antimo Migliaccio +6 moreopenaire +3 more sourcesCCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets +12 morewiley +1 more sourceCD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu +8 morewiley +1 more sourceCommon variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. [PDF]
, 2012 Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility ...Dutra-Clarke, Ana, CIMBA, SWE-BRCA, Bruno Buecher, Theo A. Van Os, Dorfling, Cecelia M., Beesley, Jonathan, Donaldson, A., Mark H Greene, Verhoef, Senno, Tihomirova, L, Pankratz, Vernon, Engel, C., Muy-Kheng Tea, Barrowdale, D., Douglas, F., Maria A Caligo, Lespérance, B, Anne Marie Gerdes, Barkardottir, Rosa B, Varon-Mateeva, Raymonda, Ozcelik, Hilmi, Kast, K, Raymonda Varon Mateeva, Hurteau, J., Meindl, A., Heli Nevanlinna, Diez, O., Patricia A. Ganz, Harbst, K, Jennifer T Loud, de la Hoya, Miguel, Odunsi, K, Andrew K. Godwin, Jan C. Oosterwijk, Dorfling, Cecelia, Skytte, Anne-Bine, Zlowowcka-Perlowska, Elzbieta, Paolo Peterlongo, Bonanni, Bernardo, Ana Osorio, John L Hopper, Walker, L, Arnold, N, Morrison, Patrick, Hopper, JL, Yuan C. Ding, Arver, Brita, Ausems, Margreet, Brita Arver, Niederacher, D, Lubinski, Jan, Tihomirova, L., Kuchenbaecker, Karoline B, Ana Dutra Clarke, Gómez Garcia, Encarna B., Douglas F. Easton, Brewer, C., Mulligan, A.M., Osorio, A, Antonis C. Antoniou, Simone Heidemann, Esther M John, Mazoyer, S, Calender, A, Blanco, I, Rosa B. Barkardottir, Patrick J Morrison, Lee, A, Papi, Laura, GEMO Collaborators Study, Beattie, M.S., Lindblom, A., van Os, Theo A, van Rensburg, Elizabeth Jansen, van Os, Theo, Platte, Radka, Mieke Kriege, Spurdle, Amanda B, Antoniou, Antonis, Kirk, J, Ganz, Patricia A, Greene, Mark H., Ferrer, Sandra F, Gross, Jenny, Susan L Neuhausen, Yuan C Ding, Os, T.A., Mortemousque, Isabelle, Kirk, Judy, Ignacio Blanco, Hansen, T.V., Donaldson, A, Fredericksen, Z, Eeles, R., Hopper, J.L., Andrea Gehrig, Taru A Muranen, Godwin, AK, Nathanson, K, Buys, S., Peterlongo, Paolo, Kwong, A., Varon-Mateeva, R, Calender, A., Kruse, Torben A, Ros Eeles, Muy-Kheng, Tea, Terry, Mary, Kuchenbaecker, K. B., Montagna, M., Fiorica, J, Kruse, Torben A., Noralane M. Lindor, Gadzicki, D., Lindor, Noralane M, Loud, Jennifer, Pankratz, Vernon S, Davidson, R., Soucy, Penny, Raymonda Varon-Mateeva, D. E. Antoine Pauw, Brewer, Carole, Study Gemo Collaborators, Kruse, T.A., Judy Kirk, Sue Healey, Gerdes, Anne-Marie, Singer, Christian, Radka Platte, Engel, Christoph, Taru A. Muranen, Lindblom, Annika, Annika Lindblom, Torben A. Kruse, Ligtenberg, Marjolijn J., Schäfer, Dieter, Muranen, Taru, Xiaoqing Chen, Verhoef, S, Kirchhoff, T., Prieur, Fabienne, Hansen, Thomas V., Morrison, Patrick J., Godwin, Andrew K, Christian Sutter, Meindl, A, D. Geschwantler Kaulich, Muy Kheng Tea, Karlan, B.Y., Toland, Amanda E, Gómez Garcia, EB, Dieter Niederacher, Collée, J. Margriet, Wijnen, J., Ottini, Laura, Gross, J, Orland Diez, Os, T.A. van, Evans, Gareth; id_orcid, Isaacs, Claudine, Peterlongo, P, Jaworska, K., Fredericksen, Z., Jaworska, Katarzyna, Wijnen, J, Loman, Niklas,, Ozcelik, H, Rosa B Barkardottir, Manoukian, S., Rogers, Mark, Daniel Barrowdale, Gaudet, M., Hogervorst, Frans B, Adlard, J, Easton, Douglas F., Léoné, Mélanie, van Os , Theo, Fineberg, E, Byron, John, Collee, Margriet, Bernard Peissel, SWE-BRCA Study Collaborator, Caligo, MA, Lazaro, C, Muranen, TA, Ausems, M.G., Hanne EJ Meijers-Heijboer, Wang, X.S., Ferrer, S.F., Hogervorst, F.B., Domchek, S., Schmutzler, RK, Gomez Garcia, E.B., Anne Bine Skytte, Frenay, M, Lubinski, J., Kuchenbaecker, KB, Maria A. Caligo, Sutter, C., Anne-Marie Gerdes, Helmut Deissler, Finn C Nielsen, Garcia, E.B.G., Beattie, Mary S., Caligo, Maria A, Toland, Amanda E., Penny Soucy, Mulligan, Anna Marie, Mads Thomassen, Spurdle, Amanda, EMBRACE Study Collaborator, Dolcetti, Riccardo, Mazoyer, S., Deissler, H., Eeles, Ros, Gayther, Simon A, Tea, Muy-Kheng, Marjolijn J. Ligtenberg, van Os , Theo A, Gadzicki, D, Ferrer, Sandra, Sobol, H., Lesperance, B., Kirchhoff, T, Gayther, SA, Fergus J Couch, A. De Pauw, Cristina Oliani, Hansen, TV, Lespérance, Bernard, Frost, D., Vernon S Pankratz, Terry, MB, Hansen, Thomas V, Neuhausen, Susan, Hopper, John L., Hansen, TVO, van Os, TA, Hamann, U, Conxi Lazaro, Antoniou, AC, Rosemarie Davidson, Imyanitov, E., Dorfling, C.M., Isaacs, C., Davidson, R, Teulé, A, Hansen, T.V.O., Donaldson, Alan, Kaulich, Daphne, J Margriet Collée, Kaulich, Daphne, Geschwantler, Domchek, S, Mary S Beattie, Collée, JM, Offit, K, Adlard, Julian, John M. Esther, Frost, D, Cook, J., Schaefer, Dieter, Wang, XS, Ottini, L, Wang, Xianshu, Caligo, Maria, Peock, Susan, Karlan, BY, Elizabeth Jansen van Rensburg, Terry, MU, Jakubowska, Anna, Papi, L., Lee, A., Nielsen, FC, Paillerets, B. Bressac-de, John, EM, Embrace Hebon, Mulligan, AM, Kriege, M, Muranen, Taru A., Gayther, Simon, Teo, S.H., Mulligan, AU, Meijers-Heijboer, HE, Dieter Schafer, Rita K. Schmutzler, Wang, X, Sutter, C, Susan Domchek, Piedmonte, Marion, Ganz, P.A., Lalloo, F., Bove, Betsy, Alan Donaldson, E. Jansen Van Rensburg, Evans, D G, Kriege, Mieke, Ferrer, Sandra U., Schafer, D., Durda, K., Adlard, J., Loris Bernard, Encarna B. Gomez Garcia, Hamann, Ute, Miguel De La Hoya, Singer, Christian F, Norbert Arnold, Ausems, MG, Easton, Douglas, McGuffog, L., Peissel, Bernard, Tomas Kirchhoff, Blanco, I., Buys, S, Nathanson, Kate, Miron, A., Collee, M, Ganz, PA, Frost, Debra, Radice, Paolo, Arnold, Norbert, Rebbeck, T, Kast, Karin, Lubinski, J, Barkardottir, Rosa, Caldes, T., Frans B Hogervorst, Alexander Miron, Sinilnikova, OM, Meijers-Heijboer, Hanne E, Lisa Walker, Frans B. Hogervorst, Rosenquist, Richard,, Riccardo Dolcetti, Valle, J. Del, Chris Jacobs, Fiorica, J., Ozcelik, H., Trinidad Caldes, Stoppa-Lyonnet, D., Léoné, M, Ferrer, Sandra,, K. Investigators, Dorkins, H, Cohn, David, Kuchenbaecker, K.B., Wijnen, J. van, van Os, Theo A., Hansen, Thomas VO, Katarzyna Durda, Morrison, PJ, Wijnen, Juul, David Cohn, Andrés, Raquel, Valle, J Del, Marc Frenay, Karin Kast, Huw Dorkins, Caldes, T, Oosterwijk, Jan, Heidemann, Simone, Hogervorst, FB, Margreet Gem Ausems, Stoppa-Lyonnet, D, Ligtenberg, M.J., Peterlongo, P., Garcia, Encarna B. Gomez, John, Esther, Greene, Mark H, Daphne Kaulich, Teule, A., Olah, E., Gehrig, Andrea, Montagna, M, Ligtenberg, Marjolijn, Beattie, Mary, Anneliese Fink-Retter, Beattie, MS, Vijai Joseph, Kaulich, DG, Kaulich, DU, E. Study, Jackie Cook, Mulligan, Anna, Marie, Encarna B Gómez Garcia, Neuhausen, Susan L, Terry, Mary, Beth, Karlsson, P., Lee, Andrew Roger, Barbara Wappenschmidt, Meindl, Alfons, Terry, Mary,, Neuhausen, S.L., Del Valle, J, van Os, T.A., Lazaro, Conxi, Olah, E, Durda, Katarzyna, Alain Calender, Evgeny Imyanitov, Anna Marie Mulligan, Soucy, P., E. Zlowocka Perlowska, Toland, Amanda, Złowowcka-Perłowska, Elżbieta, Isabelle Mortemousque, Durda, K, Dorkins, Huw, Healey, S, Chen, Xiaoqing, Couch, Fergus, Rosenquist, Richard, Research H. Facility, EMBRACE, Dorothea Gadzicki, Preisler-Adams, S., Glendon, Gord, Karoline B. Kuchenbaecker, Toland, A.E., Karlan, Beth, Greene, M.H., Kaulich, Daphne U., Nevanlinna, H., Hoya, M. de la, Elżbieta Złowowcka-Perłowska, McGuffog, Lesley, Lazaro, C (Conxi), Hilmi Ozcelik, Karoline B Kuchenbaecker, Melanie Leone, Złowowcka-Perłowska, E, Ana Dutra-Clarke, Muranen, Taru A, Lee, Andrew, Jensen, UB, Houdayer, Claude, Raquel Andres, Meijers-Heijboer, H.E., Mazoyer, Sylvie, Christian F. Singer, Olga M Sinilnikova, Hopper, John, Schmutzler, Rita, Platte, R, Antoniou, A.C., Claudine Isaacs, Ellis, Steve D, Terry, Mary U, Singer, CF, Ding, Yuan C., Blanco, Ignacio, Mulligan, Anna,, Oosterwijk, JC, Zlowowcka-Perłowska, Elżbieta, Andrulis, IL, HEBON Study Collaborator, Pankratz, VS, Lesley Mcguffog, Loud, J.T., Chen, XQ, Goldgar, D., Collée, J M, Ausems, Margreet GEM, Ava Kwong, Byron, J., Siranoush Manoukian, Nevanlinna, H, Terry, Mary B, Marjolijn J Ligtenberg, Goldgar, D, Mark H. Greene, Sylvie Mazoyer, Fink-Retter, A., Meijers-Heijboer, Hanne E J, Hanne E. J. Meijers Heijboer, Dorfling, CM, Loman, N., Zaffaroni, Daniela, Preisler-Adams, Sabine, Pankratz, V.S., Chen, X., Heidemann, S, Simard, J., Sobol, Hagay, Easton, D.F., Kwong, A, Sabine Preisler-Adams, Per Karlsson, Fiorica, James, Bernard, L, Godwin, Andrew K., Mary Beth Terry, Radice, P, Niklas Loman, Chenevix-Trench, G., Daly, Mary, V. Joseph, Ausems, MGEM, Sinilnikova, O.M., Terry, Mary Beth, Glendon, G, Ding, Y.C., Ausems, Margreet G. E. M., Elzbieta Złowowcka Perłowska, Muranen, T.A., Hansen, Thomas V. O., Lazaro, C., kConFab Investigators, Buecher, B, Imyanitov, E, Joseph, Vijai, Christoph Engel, van Rensburg, Elizabeth, Jansen, Loud, Jennifer T., Bernard, Loris, Betsy Bove, Ausems, M.G.E.M., Couch, Fergus J, Paterson, J., Garcia, EBG, van Rensburg, EU, Andrulis, Irene L, Barkardottir, Rosa B., Buecher, B., Ganz, Patricia, Olga M. Sinilnikova, Wappenschmidt, B, Zachary Fredericksen, Elena Fineberg, Niederacher, D., Simon A. Gayther, Douglas, F, Hurteau, J, Mia Gaudet, Kunle Odunsi, Cancer Study S. B. Swedish Breast, Carole Brewer, de Pauw, Antoine, Greene, MH, Karlan, Beth Y, Piedmonte, M, Laima Tihomirova, van Rensburg, EJ, Georgia Chenevix-Trench, Osorio, Ana, Bressac-de Paillerets, B., Offit, Kenneth, Nielsen, Finn, van Rensburg, Elizabeth,, Debra Frost, Piedmonte, M., et al., Mercedes Duran, Buecher, Bruno, Jensen, Uffe B, Southey, Melissa, Houdayer, C., Barrowdale, D, Jaworska, K, Spurdle, Amanda B., Kast, K., Nielsen, Finn C, Evans, D Gareth, Bonanni, B, Spurdle, AB, Ligtenberg, Marjolijn J, Greene, Mark, Soucy, P, Southey, M, Hagay Sobol, Evans, DG, Bove, B, Prieur, F, Rebbeck, Tim, Melissa Southey, Cecelia M Dorfling, Nina Ditsch, Frenay, M., Neuhausen, Susan L., Miron, A, Platte, R., Bove, B., Fink-Retter, Anneliese, Fiebig, B, Byron, J, Hodgson, Shirley, Schaefer, D, Jean Hurteau, Shirley Hodgson, Kate Nathanson, de Pauw, A, Oliani, C, Fineberg, E., Antoniou, Antonis C, Kaulich, Daphne,, Trevor Cole, Rogers, M.T., Gayther, Simon A., Paterson, Joan, Andrew K Godwin, Amanda E. Toland, Britta Fiebig, Zaffaroni, D., Joan Paterson, Ditsch, N, Oosterwijk, Jan C., Andres, R., Joseph, V, Fiebig, Britta, Bressac- de Paillerets, Brigitte, Thomassen, Mads, Meijers-Heijboer, HEJ, Soo-Hwang Teo, GEMO Study Collaborator, Prieur, F., Kruse, TA, Tihomirova, Laima, Preisler-Adams, S, Richard Rosenquist, Ferrer, Sandra, Fert, Daphne Geschwantler Kaulich, Rebbeck, T., Leone, M., Ellis, Steve, Thomas V. O. Hansen, Kenneth Offit, Jan Lubinski, Evans, D. Gareth, John Byron, Noralane M Lindor, Walker, Lisa, Marion Piedmonte, Ellis, Steve D., Jonathan Beesley, Caron, O., Heidemann, S., Diez, O, Ditsch, N., Easton, Douglas F, Jacobs, C, Steve D. Ellis, Hogervorst, Frans B., Theo A van Os, Christian F Singer, Morrison, P.J., Niederacher, Dieter, Chenevix-Trench, G, Teo, Soo-Hwang, Mary S. Beattie, Arver, B., Cohn, D., Mark T Rogers, Del Valle, J., Jensen, Uffe B., Lund University., Dolcetti, R, van Wijnen, J (Juul), Gehrig, A, Teulé, Alex, D. Gareth Evans, Dominique Stoppa Lyonnet, Oosterwijk, J.C., Pankratz, Vernon S., Geschwantler Kaulich, Daphne, Couch, FJ, Offit, K., Evans, D.G., Jensen, Uffe, Meijers-Heijboer, Hanne EJ, Eeles, R, Nevanlinna, Heli, Schäfer, D, Cook, Jackie, Ditsch, Nina, Healey, S., John L. Hopper, Jacques Simard, Ligtenberg, MJ, Hodgson, S., Benítez, J, van Rensburg, Elizabeth U., Engel, C, van Rensburg, Elizabeth J, Gehrig, A., Durán, M, Meijers-Heijboer, Hanne, Peissel, B., Simard, Jacques, Jakubowska, A, Hogervorst, Frans, Gayther, S.A., Glendon, G., Uffe B. Jensen, Caron, O (Olivier), J. Del Valle, Ding, Yuan, Beesley, J, Odunsi, Kunle, Terry, Mary U., Odunsi, K., Jacobs, Chris, Valle, J D, van Rensburg, Elizabeth U, Sabine Preisler Adams, Amanda E Toland, Cecelia M. Dorfling, Terry, M.U., Diez, Orland, Couch, Fergus J., Mulligan, Anna U., Benítez, Javier, Lindor, N.M., Sandra Ferrer, Sandra Fert Ferrer, Mulligan, Anna M, Joseph Vijai, Dutra-Clarke, A., Douglas, Fiona, Beattie, Mary S, Mulligan, Anna U, Couch, F.J., Loud, Jennifer T, Paterson, J, Thomas VO Hansen, Daly, M., Jenny Gross, Chen, X, Ellis, S.D., Montagna, Marco, Hamann, U., Patrick J. Morrison, Teo, SH, Ding, Yuan C, Steve D Ellis, Toland, AE, Douglas F Easton, Ferrer, Sandra Fert, Ausems, Margreet G E M, Saundra Buys, Fabienne Prieur, Kriege, M., Gómez Garcia, Encarna B, Irene L Andrulis, Mulligan, Anna, Karlan, Beth Y., A. Van, Laura Ottini, Kwong, Ava, Torben A Kruse, Manoukian, S, Laura Papi, Spurdle, A.B., Collée, J Margriet, Gross, J., Benitez, J., Caligo, Maria A., Andrulis, Irene, Gaudet, M, Neuhausen, SL, Simard, J, Andrés, R, Skytte, AB, James Fiorica, Kuchenbaecker, Karoline, Isaacs, C, Mortemousque, I, Mary Terry, Hurteau, Jean, Kruse, Torben, Ding, YC, Fiona Douglas, Brewer, C, null null, Mortemousque, I., Olah, Edith, Zlowowcka-Perlowska, E., Bressac-de Paillerets, B, Lindor, NM, John Em, CIMBA Study Collaborator, Sinilnikova, Olga M, Caron, Olivier, Andrulis, Irene L., Arnold, N., Gerdes, A-M, Thomassen, M, Soo Hwang Teo, Kuchenbaecker, Karoline B., Harbst, K., Juul Wijnen, Uffe B Jensen, Davidson, Rosemarie, Tea, M-K, David Goldgar, Bernardo Bonanni, Sinilnikova, Olga Muno, Hansen, Thomas, Jennifer T. Loud, Ganz, Patricia A., John, E.M., van Rensburg, Elizabeth, Easton, DF, Fiebig, B., Dorfling, Cecelia M, Harbst, Katja, Terry, M.B., Piedmonte, M., Gaudet, Mia, Ottini, L., Teo, S-H, Duran, M., Susan Peock, Kaulich, Daphne G, Barkardottir, RB, Zlowowcka-Perlowska, E, Nathanson, K., Singer, C.F., Simon A Gayther, Dolcetti, R., Kaulich, Daphne U, Senno Verhoef, John, Esther M., Chenevix-Trench, Georgia, Elizabeth Van Rensburg, J Del Valle, Papi, L, Skytte, A-B, Kaulich, D.G., Fink-Retter, A, Lalloo, Fiona, Godwin, A.K., Alex Teule, Ute Hamann, Lindor, Noralane, Marco Montagna, Valle, JD, Pauw, A. de, John, Esther M, Antoniou, Antonis C., Verhoef, S., Katarzyna Jaworska, Varon-Mateeva, R., Barrowdale, Daniel, Andrulis, I.L., Caligo, M.A., Oliani, C., Swe Brca Cimba, Sutter, Christian, Meijers-Heijboer, Hanne EJ., Rosenquist, R., Karlsson, P, D Gareth Evans, Frenay, Marc, Anna Mulligan, Claude Houdayer, Schmutzler, R.K., Anneliese Fink Retter, Brigitte Bressac De Paillerets, Cook, J.L., Cole, T., Lalloo, F, Anna Jakubowska, Bressac-de Paillerets, Brigitte, Fiona Lalloo, Jacobs, C., Katja Harbst, Karlsson, Per W., Cohn, D, Joseph, V., Collee, J.M., Sinilnikova, Olga M., Bonanni, B., de Pauw, A., Fineberg, Elena, Amanda B. Spurdle, Healey, Sue, Daly, M, Antoniou, A. C., Chen, X.Q., Rita K Schmutzler, Rogers, MT, Patricia A Ganz, Beesley, J., Calender, Alain, Finn C. Nielsen, Skytte, A.B., Gadzicki, Dorothea, Loman, N, Cook, J, Wappenschmidt, B., Beth Y. Karlan, Dorkins, H., Kaulich, D.U., Mary Daly, Hopper, John L, Domchek, Susan, Lindblom, A, Tim Rebbeck, Vernon S. Pankratz, Godwin, Andrew, Oosterwijk, Jan C, de la Hoya, M, Nielsen, F.C., Meijers-Heijboer, Hanne E. J., Thomassen, M., Deissler, Helmut, Kirchhoff, Tomas, Barkardottir, R.B., Rogers, Mark T., Daniela Zaffaroni, Harbst, Katja,, Paolo Radice, Gómez Garcia, Encarna, Buys, Saundra, Ligtenberg, M.J.L., Morrison, Patrick J, J. Margriet Collee, Jan C Oosterwijk, Ausems, Margreet G, Tea, MK, Peterlongo, Paulo, Miron, Alexander, Fergus J. Couch, Schmutzler, Rita K., Ferrer, Sandra U, Terry Mu, Singer, Christian F., Peock, S., Irene L. Andrulis, Georgia Chenevix Trench, Tea, M.K., Bernard, L., Terry Mb, Houdayer, C, Durán, Mercedes, Southey, M., Peock, S, Goldgar, David, Zaffaroni, D, Hodgson, S, Cole, Trevor, Imyanitov, Evgeny, Nielsen, Finn C., Rensburg, E.J. van, Jensen, U.B., Ferrer, SF, Jansen van Rensburg, Elizabeth, Bernard Lesperance, Gerdes, A.M., Oliani, Cristina, Arver, B, Deissler, H, HEBON, Ellis, SD, Karlsson, Per, Julian Adlard, Beth Y Karlan, Manoukian, Siranoush, Meijers-Heijboer, H.E.J., Javier Benitez, Osorio, A., Collee, M., Radice, P., Alfons Meindl, Andrew Lee, Mark T. Rogers, Kirk, J., Jakubowska, A., Gerdes, AM, Schmutzler, Rita K, Wappenschmidt, Barbara, Ferrer, SU, Thomassen, Marga, Rogers, Mark T, Caldes, Trinidad, Amanda B Spurdle, Lindor, Noralane M., Sinilnikova, Olga, Gord Glendon, Study G. Collaborators, Peissel, B, Dutra-Clarke, A, Edith Olah, McGuffog, L, Kaulich, Daphne Geschwantler, Loud, JT, Xianshu Wang, Brigitte Bressac- de Paillerets, Anne-Bine Skytte, Ferrer, S.U., Antonis C Antoniou, Rosenquist, R, Caron, O, Loman, Niklas, Sobol, H, Cole, T, Olivier Caron, Antoine de Pauw, Fredericksen, Zachary, Dominique Stoppa-Lyonnet, Meijers-Heijboer, E.J., Susan L. Neuhausen +999 morecore +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceAssociation of genetic variants at 8q24 with breast cancer risk. [PDF]
, 2008 Recent whole genome association studies of prostate, breast, and colorectal cancer have identified susceptibility loci on 8q24. We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both ...Johnson, Nichola, Fletcher, Olivia, Coupland, Ben, dos Santos Silva, Isabel, Gibson, Lorna, Leonard, Angela, Fraser, Agnes, Ashworth, Alan, Houlston, Richard, Peto, Julian +9 morecore +1 more sourceHijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceTriple negative breast cancer - prognostic factors and survival [PDF]
Radiology and Oncology, 2011 Triple negative breast cancer (TNBC) is defined by a lack of expression of both estrogen (ER) and progesteron (PgR) receptors as well as human epidermal growth factor receptor 2 (HER2). Our retrospective analysis addressed prognostic factors for short- and long-term outcomes of patients (pts) with TNBC pts treated in routine clinical practice. PATIENT Borštnar, Simona, Frković-Grazio, Snježana, Matos, Erika, Možina, Barbara, Ovčariček, Tanja +4 moreopenaire +3 more sources
