Results 91 to 100 of about 192,885 (309)
USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourceMicroRNAs in triple-negative breast cancer
Neoplasma, 2018 Triple-negative breast cancer (TNBC) is a molecular subtype of breast cancer with one of the worst prognoses. Current treatment is based on chemo- and/or radiotherapy and surgery. New targets, however, offering other therapeutic approaches, have been identified.Kolečková, Markéta, Janíková, Mária, Kolář, Zdeněk +2 moreopenaire +4 more sources19p13.1 is a triple-negative-specific breast cancer susceptibility locus
, 2012 The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with the risk of ovarian cancer.Olson, J.E., Schoemaker, MJ, Reed, M.W.R. (Malcolm), Perez, JIA, Beesley, Jonathan, Severi, G., Knight, Julia A., Engel, C., Anton-Culver, H., Muir, K; id_orcid, Aittomaki, K., Ademuyiwa, Foluso, Shen, C Y, Kristensen, V, Hsiung, C. -N., Kosma, V.M., Beckmann, Matthias W., Meindl, A., Weaver, J., Perkins, A., Schmidt, Marjanka K., Couch, F.J. (Fergus), Chang Claude, Jenny, Milne, R.L. (Roger), Perez, J.I.A., Alnaes, G. G., Lissowska, J. (Jolanta), Dünnebier, Thomas, Lambrechts, D., Figueroa, J D, Vachon, C., Broeks, A., Hopper, JL, Vachon, C M, Ekici, Arif B., Hsiung, C N, Tollenaar, Robert A. E. M., Czene, Kamila, Hartikainen, J M, Cross, SS, Orr, Nick, Pérez, José Ignacio Arias, Miron, P., Sinn, H.P., Ademuyiwa, F., Milne, R L, Hsiung, Chia-Ni, Menegaux, F., Mueller, Heiko, Vachon, CM, Grip, M. (Mervi), Sohn, C, Mulligan, A.M., Easton, D F, Vachon, Celine M, Schneeweiss, Andreas, Pylkäs, Katri, Stevens, K. (Kristen), Benítez, J. (Javier), Yu, JC, Muller, H, Anton-Culver, H. (Hoda), Ambrosone, CB, Nielsen, SF, Bojesen, S.E., Braaf, L.M. (Linde), Kosma, V.-M., Lindblom, A., Johnson, N, Apicella, C., Park, Daniel J, Garcia-Closas, M., Børresen-Dale, Anne-Lise, Ulrich Ulmer, Hans, Pathak, H B, Olson, Janet E, Ko, Yon-Dschun, Nordestgaard, B.G., Hopper, J. L., Fredericksen, Z, Rudiger, T., Milne, R.L., Hopper, J.L., Hsu, Huan-Ming, Cox, A, Godwin, AK, Bojesen, Stig E., Jukkola-Vuorinen, Arja, Borresen-Dale, Anne-Lise, Vrieling, Alina, Hsu, H. -M., Alnsæ, Grethe Grenaker, Milne, Roger L, Peterlongo, Paolo, Brauch, H, Perez, J.I.A. (Jose Ignacio Arias), Pharoah, P.D.P., Borresen-Dale, A. -L., Mannermaa, A. (Arto), Reed, M.W.R., Menegaux, Florence, Perkins, Annie, Ulmer, H. U., Cox, Angela, AOCS Grp, Fountzilas, George, Soini, Y. (Ylermi), Grip, M, Vachon, Celine M., Stavropoulou, A, Lophatananon, Artitaya, Network, The Genica, Hooning, M J, Winqvist, Robert, Manoukian, S. (Siranoush), Alnæs, Grethe Grenaker, Johnson, Nichola, Giles, GG, Schmidt, M K, Ashworth, A., Giles, G G, Hartmann, Arndt, Pharoah, P.P., Engel, Christoph, Sinn, H P, Hall, Per, Lindblom, Annika, Reed, Malcom W., Mulligan, A M, Aittomäki, K. (Kristiina), Baglietto, L, Humphreys, Manjeet K., Hwang, H, Dieudonne, Anne Sophie, Hsu, Huan Ming, Sherman, Mark E., Braaf, Linde M., Rüdiger, Thomas, Zamora, M Pilar, Fletcher, O. (Olivia), Beckmann, M W, Knight, J A, Kose, M.L., Greco, Dario, Godwin, Andrew K, Broeks, A. (Annegien), Meindl, A, Severi, G, Brauch, H., Dunning, A.M. (Alison), Burwinkel, B., Dieudonné, A.-S. (Anne-Sophie), Hsiung, Chia Ni, Lambrechts, Diether, Bojesen, SE, Hamann, U. (Ute), Ulmer, H U, Hsu, H.-M., Orr, N, Tomlinson, Ian, Nielsen, S. F., Severi, G. (Gianluca), Rud̈iger, T. (Thomas), Giles, Graham G, Ziogas, A. (Argyrios), Dunnebier, T., Dieudonne, AS, Peterlongo, P, Southey, Melissa C., Fredericksen, Z., Nickels, S. (Stefan), Bojesen, S. E., Milne, RL, Beckmann, MW, Slager, Susan, Andrulis, I. L., Cross, S.S., Manoukian, S., Braaf, L.M., Bernstein, L., Blomqvist, Carl, Milne, Roger L., Ademuyiwa, F. (Foluso), Brenner, H, Easton, Douglas F., Fasching, P A, Perez, J. I. A., Orr, Nicholas, Vachon, C. M., Andrulis, I.L. (Irene), Slager, S., Christiaens, M.R., Wang, X.S., Giles, G.G., Hartikainen, Jaana M, Reed, MW, Hooning, Maartje J, Schmutzler, RK, Flesch Janys, Dieter, Garcia Closas, Montserrat, Sohn, Christof, Humphreys, M.K. (Manjeet), Rosenberg, E H, Kosel, Matthew L, Peto, J., Knight, J.A. (Julia), Seynaeve, C.M. (Caroline), Olson, Janet E., Hooning, M. J., Tollenaar, R.A.E.M. (Rob), AOCS Group, Blomqvist, C, Shen, CY, Dur, Christina Clarke, Chenevix Trench, Georgia, Pathak, S.S., Rosenberg, E. H., Mulligan, Anna Marie, Couch, F J, Dos Santos Silva, Isabel, Reed, M W, Yu, J.-C., Müller, H. (Heiko), Park, D.J. (Daniel), Grenaker Alnaes, G., Tomlinson, I.P. (Ian), Reed, M. W., Dur, C.C., Sinn, Hans-Peter, Rosenberg, E.H. (Efraim), Cordina-Duverger, E, Figueroa, J. D., Margolin, Sara, Blomqvist, Carl,, Anton Culver, Hoda, Hopper, John L., Sawyer, Elinor, Stevens, Kristen N., Hamann, U, Lophatananon, A, Wang, Q. (Qing), Sherman, M.E. (Mark), Wang, XS, Wang, Xianshu, Cordina-Duverger, E., Nickels, Stefan, Cross, Simon S., Brenner, H. (Hermann), McLean, C A, Cox, A. (Angela), Pykäs, K. (Katri), Schmutzler, R. K., Pharoah, P P, Stevens, K N, Zamora, María Pilar, Schneeweiss, A., John, EM, Silva, Isabel dos Santos, Yu, J-C. (Jyh-Cherng), Mulligan, AM, Truong, T. (Thérèse), Swann, Ruth, Beckmann, Matthias W, Fasching, P.A., Beesley, J. (Jonathan), Southey, M. C., Reed, Malcom W, Hartmann, A. (Arndt), Wang, Q, Kosel, M L, Pankratz, V.S. (Shane), Wang, X, Cross, Simon S, Dunning, Alison M, Marme, F., Baglietto, L. (Laura), Kosel, M.L., Wiangnon, Surapon, Weaver, Joellen, Bartram, C R, Brøresen Dale, Anne Lise, Burwinkel, B, Broeks, A, Tollenaar, Rob AEM, Knight, J. A., Tollenaar, RAEM, Mulligan, A. M., Truong, T., Alnæs, G.G. (Grethe), Hamann, Ute, Kerin, M. J., Kosma, Veli-Matti, Margolin, S. (Sara), Swerdlow, Anthony J., Hartmann, A, Orr, N., Godwin, A.K. (Andrew), Giles, G. G., Braaf, LM, Miron, A., Miron, A. (Alexander), Radice, Paolo, Ignacio Arias Perez, J., Hsu, HM, Humphreys, MK, Chang-Claude, J, Kosma, V. -M., Weaver, J, Hartmann, A., Barile, Monica, Schott, S. (Sarah), Peterlongo, P. (Paolo), Hall, P., Gogas, Helen J, Ziogas, A., Kosma, V M, Bojesen, Stig E, Perkins, A, Pankratz, V. S., Fountzilas, G, Hooning, Maartje, Bojesen, S E, Rosenberg, E.H., Apicella, C. (Carmel), Lophatananon, A., Peto, J, Figueroa, Jonine D, Kosel, M. (Matthew), Braaf, L M, Hsu, H M, Fredericksen, Z. (Zachary), Johnson, N. (Nichola), Investigators, Kconfab, Aittomäki, K, Easton, D. F., Hooning, M.J. (Maartje), Muller, H., Jukkola-Vuorinen, A. (Arja), Ashworth, A. (Alan), Hartikainen, JM, Puttawibul, P., Rudiger, T, Ambrosone, C. B., Eccles, D M, Peterlongo, P., Kosel, ML, Figueroa, JD, Couch, F. J., Muir, K.R. (Kenneth), Devilee, P, Nordestgaard, Brøge G., Arndt, Volker, Dwek, M., Nordestgaard, BG, Meindl, Alfons, Zamora, M. P., Hatse, S, Margolin, S., Tollenaar, R A E M, Soini, Y, Ko, Yon Dschun, Fletcher, O., Swerdlow, AJ, Flyger, H., Schoemaker, M J, Stevens, K. N., Dieudonne, A.S., Zamora, MP, Aittomäki, Kristiina, Chen, Xiaoqing, Zamora, M.P. (Pilar), Dunnebier, T, Muir, K., Glendon, Gord, Park, D.J., Nevanlinna, H., Kerin, MJ, Gogas, Helen J., Greco, D. (Dario), Blomqvist, C. (Carl), Eccles, D.M., Pylkas, K, Kosma, VM, Swerdlow, A. J., Pharoah, Paul D P, Kerin, M J, Dieudonne, A.-S., Sinn, HP, Dünnebier, T. (Thomas), Stevens, K.N., Czene, K., Soini, Y., Kristensen, V., Nordestgaard, Borge G., Silva, ID, Alnaes, GG, Sherman, M.E., Wiangnon, S. (Surapon), Fletcher, Olivia, Andrulis, IL, Rosenberg, Efraim H, Pankratz, VS, Christiaens, M.R. (Marie Rose), Puttawibul, P. (Puttisak), Chen, XQ, Ambrosone, C.B. (Christine), Mannermaa, A, Ko, Y-D. (Yon-Dschun), Greco, D., Tollenaar, R.A.E.M., Arndt, V., Dieudonne, Anne-Sophie, Hwang, H., Nevanlinna, H, Christiaens, MR, Schmutzler, R K, Kosma, Veli Matti, Nevanlinna, H. (Heli), Schoemaker, M.J., Winqvist, R., Pathak, Harsh B, Seynaeve, C, Pankratz, V.S., Chen, X., Borrensen-Dale, A.-L., Swann, R. (Ruth), McLean, C. A., Easton, D.F., Chang-Claude, Jenny, Swerdlow, A.J. (Anthony ), Godwin, Andrew K., Fasching, P. A., Radice, P, Chenevix-Trench, G., Sinn, Hans Peter, Swerdlow, Anthony J, Glendon, G, Brenner, Hermann, Pharoah, Paul P., Hatse, S., kConFab Investigators, Kristensen, V. (Vessela), Seynaeve, C., Swann, R., Winqvist, R. (Robert), Couch, Fergus J, Shen, C.Y., Wang Gohrke, Shan, Andrulis, Irene L, Yu, J C, Broeks, Annegien, Grip, Mervi, Wang-Gohrke, Shan, Apicella, Carmel, Knight, Julia A, Fountzilas, G. (George), Muir, K, Hsiung, C.-N., Schneeweiss, A. (Andreas), Dunning, A.M., Wiangnon, S, Braaf, Linde M, Hatse, S. (Sigrid), Sharma, P, Pharoah, Paul P, Ekici, A. B., Giles, Graham G., Lindblom, A. (Annika), Fletcher, O, Cordina-Duverger, E. (Emilie), Eccles, D. M., Hopper, J L, Fischer, Hans-Peter, Humphreys, M K, Ashworth, Alan, Wang-Gohrke, S., Hsiung, C.N., Johnson, N., Ademuyiwa, F, Ambrosone, Christine B., Puttawibul, Puttisak, Sherman, Mark E, Flyger, Henrik, Sawyer, E, Godwin, A K, John, E.M. (Esther), Miron, Penelope, Stavropoulou, Alexandra, Ulmer, H.U. (Hans), Kristensen, Vessela, García-Closas, M. (Montserrat), Marme, F, Shen, C.-Y., Muir, Kenneth (Kenneth R.), Kerin, Michael J, Miron, A, Hartikainen, J. (Jaana), Fountzilas, G., Miron, P, Stavropoulou, A. (Alexandra), Beckmann, M.W. (Matthias), Sinn, H.-P. (Hans-Peter), Andrulis, I L, Sherman, ME, Müller, Heiko, Guenel, P., Rosenberg, EH, Borresen-Dale, A.L., Wang-Gohrke, S, Eccles, Diana M., Kerin, M.J., John, E M, Flesch-Janys, Dieter, Dwek, M. (Miriam), Hooning, Maartje J., Guénel, P. (Pascal), Ekici, A.B. (Arif), Schoemaker, M. (Minouk), Humphreys, Manjeet K, Alnaes, G.G., Chang-Claude, J. (Jenny), McLean, CA, Cordina-Duverger, Emilie, Anton-Culver, H, Vrieling, A. (Alina), Yannoukakos, D. (Drakoulis), Ekici, Arif B, Stegmaier, C, Braaf, L. M., Marmé, Frederick, Alnaes, Grethe Grenaker, Hsiung, CN, Schoemaker, M. J., Schmutzler, R.K. (Rita), Tomlinson, I, Peto, Julian, Olson, J E, Sinn, H.-P., Easton, Douglas F, Dur, CC, Zamora, M.P., Southey, M C, Hsiung, C.-N. (Chia-Ni), Wang, Q., Chenevix-Trench, G, GENICA Network, Hsu, H.-M. (Huan-Ming), Schmidt, M. K., Eccles, DM, Fischer, H P, Yu, Jyh Cherng, Knight, J.A., Sohn, C., Ko, YD, Brenner, H., Cross, S.S. (Simon), Menegaux, F, Shen, C-Y. (Chen-Yang), Dieudonne, A S, Nielsen, Sune F, Schneeweiss, A, Giles, G.G. (Graham), Baglietto, Laura, Couch, FJ, Dos Santos Silva, I, Sherman, M E, Fasching, PA, Miron, P. (Penelope), Dur, C. C., Nevanlinna, Heli, Reed, M.W., Ambrosone, C.B., Sharma, P. (Pankaj), Pathak, H. B., Devilee, Peter, Slager, S, Yu, J.C., Flesch-Janys, D., Christiaens, Marie-Rose, Clarke Dur, Christina, John, E. M., Engel, C, Lissowska, J, Bartram, CR, Yannoukakos, D., Perez, J I, Glendon, G., Flesch-Janys, D, Schmidt, Marjanka K, Weaver, J. (JoEllen), Beesley, J, Christiaens, M.-R., Dur, C.C. (Christina Clarke), Glendon, G. (Gord), Jukkola-Vuorinen, A, Dwek, Miriam, Jukkola Vuorinen, Arja, Duennebier, Thomas, Couch, Fergus J., Schmidt, M.K., Benítez, Javier, Burwinkel, B. (Barbara), Fasching, Peter A., Benitez, J, Ulmer, H.U., Ekici, A B, Vachon, C. (Celine), Ulmer, HU, Zamora, M P, Garcia-Closas, Montserrat, Yannoukakos, D, Bernstein, L, Cordina Duverger, Emilie, Couch, F.J., Dunning, Alison M., Tollenaar, R A, Mannermaa, A., Sohn, C. (Christof), Cross, S. S., Chen, X, Hwang, H. (Helena), Winqvist, R, Chang-Claude, J., Hamann, U., Peto, J. (Julian), Tollenaar, Rob A. E. M., Baglietto, L., Gogas, H J, Fischer, H.-P., Beckmann, M. W., Wang, X., Lambrechts, D. (Diether), Pankratz, V Shane, Barile, M, Nordestgaard, B. G., Ruediger, Thomas, Vrieling, A., Truong, Thérèse, Jukkola-Vuorinen, A., Figueroa, Jonine D., Hartikainen, J. M., Devilee, P. (Peter), Arndt, V. (Volker), McLean, C.A. (Catriona Ann), Dunning, A M, Brauch, H. (Hiltrud), Manoukian, S, Christiaens, M. -R., Schott, S, Benitez, J., Hall, P, Sawyer, E., Olson, J.E. (Janet), Nielsen, S.F., Anton-Culver, Hoda, Dunning, A. M., Fischer, Hans Peter, Milne, R. L., Ko, Y D, Hsu, H.M., Park, DJ, Tomlinson, I., Pylkas, K., Guénel, Pascal, Nielsen, S.F. (Sune), Swerdlow, A.J., Wiangnon, S., Clarke Dur, C., Slager, S. (Susan), Apicella, C, Ambrosone, Christine B, Pathak, H.B., Perkins, A. (Annie), Kosel, Matthew L., Wang, Qin, Stegmaier, Christa, Kerin, M. (Michael), Nordestgaard, Borge G, Grenaker Alnaes, Grethe, Andrulis, Irene L., Marme, F. (Federick), Guenel, P, Ekici, A.B., Nielsen, S F, Ziogas, A, Kerin, Michael J., Ziogas, Argyrios, Nielsen, Sune F., Lissowska, J., Vrieling, A, Ambrosone, C B, Chen, X. (Xiaoqing), Dunning, AM, Czene, K, John, E.M., McLean, Catriona A, Easton, DF, Soini, Ylermi, Borresen-Dale, A.-L., Meindl, A. (Alfons), Dur, C C, Figueroa, J.D., Bojesen, S.E. (Stig), Nordestgaard, B G, Hopper, J.L. (John), Yu, Jyh-Cherng, Borresen-Dale, AL, Ko, Y.-D., Hartikainen, Jaana M., Nickels, S., Czene, K. (Kamila), Lophatananon, A. (Artitaya), Shen, C. -Y., John, Esther M., Chenevix-Trench, Georgia, Schott, S., Shen, Chen-Yang, Christiaens, M R, Vachon, C.M., Southey, M.C., Wang, X. (Xing), Godwin, A.K., Arndt, V, Swerdlow, A J, Olson, JE, Sharma, Priyanka, Ignacio Arias Pérez, José, John, Esther M, Group, Aocs, Mclean, Catriona A., Andrulis, I.L., Park, D. J., Yannoukakos, Drakoulis, Puttawibul, P, Barile, M., Pathak, Harsh B., Muir, Kenneth, Reed, Malcolm W R, Wang, Q (Qing), Schmutzler, R.K., Ekici, AB, Sherman, M. E., Kosma, V-M. (Veli-Matti), Shen, Chen Yang, Nicholas, O. (Orr), Pilar Zamora, Maria, Brauch, Hiltrud, Pathak, HB, Gogas, H. J., Wang-Gohrke, S. (Shan), Lambrechts, D, Park, D J, Chen, X.Q., Knight, JA, Stavropoulou, A., Bartram, Claus R., Grip, M., Sawyer, E.J. (Elinor), Schott, Sarah, Beesley, J., Nordestgaard, B.G. (Børge), Beckmann, M.W., Ulmer, Hans Ulrich, Fischer, H.P., Hwang, Helena, Santos Silva, I. (Isabel) dos, Greco, D, Eccles, Diana M, Chenevix-Trench, G. (Georgia), Ashworth, A, Hopper, John L, Sharma, P., Lindblom, A, Menegaux, F. (Florence), Nickels, S, Schoemaker, Minouk J, Fasching, P.A. (Peter), Mulligan, A.M. (Anna Marie), Humphreys, M. K., Pharoah, P. P., Southey, MC, Pharoah, PP, Southey, M.C. (Melissa), Perkins, Katherine Anne, Miron, Alexander, Borresen-Dale, A L, Schmutzler, Rita K., Nicholas, Orr, Gogas, H. (Helen), Easton, D.F. (Douglas), Pharoah, P.D.P. (Paul), Severi, Gianluca, Garcia-Closas, M, Seynaeve, Caroline, Pankratz, V S, dos Santos Silva, I., Devilee, P., Schoemaker, Minouk J., Nordestgaard, Børge G, Hartikainen, J.M., Fischer, HP, Gogas, H.J., Radice, P. (Paolo), Stevens, Kristen N, Burwinkel, Barbara, Humphreys, M.K., Eccles, D. (Diana), Southey, Melissa C, Manoukian, Siranoush, Schmidt, M.K. (Marjanka), Alnaes, G G, Margolin, S, Flyger, H, Radice, P., Stevens, KN, Stegmaier, C., Dieudonne, A. -S., Flyger, H. (Henrik), Swann, R, McLean, C.A., Tollenaar, R. A. E. M., Schmutzler, Rita K, Cox, A., Rosenberg, Efraim H., Bartram, Claus R, Barile, M. (Monica), Hooning, M.J., Brøresen-Dale, A.-L. (Anne-Lise), Godwin, A. K., Bernstein, L. (Leslie), Cross, S S, Christiaens, Marie Rose, Mannermaa, Arto, Lissowska, Jolanta, Truong, T, Dwek, M, Ko, Y.D., Bartram, C.R. (Claus), Stegmaier, C. (Christa), Hatse, Sigrid, Silva, I.D., Bartram, C. R., Kosel, M. L., Fasching, Peter A, Gogas, HJ, Bernstein, Leslie, Park, Daniel J., Hall, P. (Per), Flesch-Janys, D. (Dieter), Fredericksen, Zachary, Olson, J. E., Engel, C. (Christoph), Blomqvist, C., Bartram, C.R., Arias Perez, Jose Ignacio, Figueroa, J.D. (Jonine) +855 morecore +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more sourceLongitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht +14 morewiley +1 more sourceMissense variants in ATM in 26,101 breast cancer cases and 29,842 controls. [PDF]
, 2010 BACKGROUND: Truncating mutations in ATM have been shown to increase the risk of breast cancer but the effect of missense variants remains contentious.Schürmann, Peter, Olson, J.E., Seynaeve, C., Pita, Guillermo, Malcolm W.R. Reed, Beesley, Jonathan, Severi, G., Couch, Fergus J, Wang Gohrke, Shan, Jianjun Liu, Anton-Culver, H., Broeks, Annegien, Aittomaki, K., Kang, Daehee, Wang-Gohrke, Shan, Zachary Fredericksen, Hall, Katrine Blædel Pinholt, Kosma, V.M., Beckmann, Matthias W., Meindl, A., Heli Nevanlinna, Silva, Andreá Lema Da, Dunning, A.M., Morrison, J, Schmidt, Marjanka K., Keun-Young Yoo, van Leeuwen, F.E., Jenny Chang-Claude, Chang Claude, Jenny, Per Hall, Michael Bremer, Giles, Graham G., Georgia Chenevix-Trench, Fletcher, O, Noh, D.Y., Waltes, R., Silva, I. dos Santos, Brinton, L.A., Broeks, A., Bogdanova, Natalia V., Hopper, JL, Ekici, Arif B., Ashworth, Alan, Wang-Gohrke, S., Czene, Kamila, Smith, L (Letitia), Johnson, N., Orr, Nick, Spurdle, Amanda B., Van't Veer, L.J., Brinton, Louise A., Louise A. Brinton, Schurmann, P, Spurdle, AB, Flyger, Henrik, Melissa C. Southey, Kataja, V, Nordestgaard, Børge G., Douglas F. Easton, Veli-Matti Kosma, Kristiina Aittomäki, Liu, Jianjun, Elliott, Graeme, Ahmed, S., Zalutsky, Iosif V., Morrison, Jonathan, Pharoah, P.D., Bojesen, S.E., Breast Cancer Association Consortium, Lindblom, A., Platte, R., Platte, Radka, Spurdle, Amanda B, Kang, D., Pita, G., Johnson, N, Garcia-Closas, M., Olson, Janet E, Ko, Yon-Dschun, Nordestgaard, B.G., Antonenkova, N.N., Isabel dos Santos Silva, Fredericksen, Z, Milne, R.L., Laura Baglietto, Hopper, J.L., Cox, A, Manjeet K. Humphreys, García Closas, Montserrat, Nichola Johnson, Wang-Gohrke, S, Bojesen, Stig E., Dork, T., Milne, Roger L, Pharoah, P.D.P., Brauch, H, Brinton, LA, Reed, M.W.R., Humphreys, Manjeet K, Pita, G, Cox, Angela, Liu, J.J., Brock, I, AOCS Grp, Anton-Culver, H, Elliott, George Arthur, Olivia Fletcher, Ekici, Arif B, Marjanka K. Schmidt, Claus R. Bartram, Ian Brock, Jonathan Beesley, Bremer Michael, Peto, Julian, Johnson, Nichola, Dallas R. English, Giles, GG, Easton, Douglas F, Ashworth, A., Børge G. Nordestgaard, Alison M. Dunning, Radka Platte, Chenevix-Trench, G, Hall, Per, Lindblom, Annika, Annika Lindblom, Schurmann, P., Asperen, C.J. van, Ko, YD, GENICA Consortium, Baglietto, L, Humphreys, Manjeet K., Peter Devilee, Baglietto, Laura, Morrison, Ann Judith, Couch, FJ, Fasching, PA, Brinton, Louise A, English, Dallas R., Meindl, A, Severi, G, Brauch, H., Reed, Malcolm W. R., Nevanlinna, Heli, Burwinkel, B., Dong Young Noh, Jonathan Morrison, Reed, M.W., Bojesen, SE, John L. Hopper, Devilee, Peter, Orr, N, Javier Benítez, Hoda Anton-Culver, Lissowska, J, Tollenaar, Rob A E M, Bartram, CR, Giles, Graham G, Noh, DY, Schmidt, Marjanka K, Southey, Melissa C., Fredericksen, Z., Milne, RL, Beckmann, MW, Beesley, J, Yoo, Keun-Young, Blomqvist, Carl, Chanock, S., Milne, Roger L., Easton, Douglas F., Tuomas Heikkinen, Couch, Fergus J., Alan Ashworth, Schmidt, M.K., Benítez, Javier, Montserrat García-Closas, Wang, X.S., Giles, G.G., Fasching, Peter A., Barbara Burwinkel, Benitez, J, Schmutzler, RK, Dörk, Thilo, Peto, J., Couch, F.J., Angela Cox, Dunning, Alison M., Arif B. Ekici, Olson, Janet E., Kamila Czene, dos Santos Silva, Isabel, Mannermaa, A., Pharoah, Paul D. P., Stig E. Bojesen, Larsen, Marie Sofie Yoo, AOCS Group, Hiltrud Brauch, Blomqvist, C, Hamann, U., Chang-Claude, J., Tollenaar, Rob A. E. M., Vesa Kataja, Baglietto, L., Chenevix Trench, Georgia, Ahmed, Shahana, Veer, L.J. van 't, Wang, X., Strick, Reiner, Aittomaki, K, Strick, R, Bremer, M, Spurdle, A.B., Natalia V. Bogdanova, Margolin, Sara, Brock, I., Anton Culver, Hoda, Hopper, John L., Benitez, J., Hall, P, Waltes, Regina, Hamann, U, Zalutsky, Iosif V, Flora E. van Leeuwen, Anton-Culver, Hoda, Bogdanova, N.V., Antonenkova, NN, van Asperen, Christie J., Arias, J.I., Liu, J., Natalia N. Antonenkova, Henrik Flyger, Wang, XS, Wang, Xianshu, Liu, JJ, van Leeuwen, Flora E., Keith Humphreys, Yon-Dschun Ko, Morrison, J., Gaubert, Giles, Tollenaar, R.A., Janet E. Olson, Silva, Isabel dos Santos, Kataja, Vesa, Beckmann, Matthias W, Fasching, P.A., van Asperen, CJ, Ekici, A.B., Breast Canc Assoc Consortium, Ziogas, A, van Asperen, Christie J, Ziogas, Argyrios, Rita K. Schmutzler, Lissowska, J., Dunning, Alison M, Heikkinen, T., van 't Veer, L.J., Dunning, AM, Burwinkel, B, Czene, K, Broeks, A, Easton, DF, Tollenaar, Rob AEM, Tollenaar, RAEM, Kang, D, Zalutsky, IV, Hamann, Ute, Kosma, Veli-Matti, Dork,Thilo, Orr, N., English, D.R., Van't Veer, Laura J., Bogdanova, Natalia V, Chenevix-Trench, Georgia, Jolanta Lissowska, Humphreys, MK, Pharoah, Paul DP, Southey, M.C., Chang-Claude, J, Heikkinen, T, Sara Margolin, Ute Hamann, Rob A.E.M. Tollenaar, Smith, Letitia, Olson, JE, Annegien Broeks, Reed, MWR, Caroline Seynaeve, Leeuwen, F.E. van, Bremer, M., Roger L. Milne, Thilo Dörk, van Leeuwen, Flora E, Carl Blomqvist, Hall, P., Reed, Malcolm W R, Laura J. Van't Veer, Humphreys, K., Ziogas, A., Bojesen, Stig E, Schmutzler, R.K., Melanie Maranian, Ekici, AB, Iosif V. Zalutsky, Peto, J, Brauch, Hiltrud, Reed, Malcolm WR, Elliott, G., Amanda B. Spurdle, Chanock, Stephen, Julian Peto, Yoo, KY, Ignacio Arias, José, Bartram, Claus R., Smith, L., Beesley, J., Christie J. van Asperen, Beckmann, M.W., Daehee Kang, Argyrios Ziogas, van Leeuwen, FE, Strick, R., Yoo, K.Y., Arias, JI, Graeme Elliott, Devilee, P, Arias, José Ignacio, José Ignacio Arias, Ashworth, A, Hopper, John L, Nordestgaard, BG, Stephen Chanock, Lindblom, A, Meindl, Alfons, Bogdanova, NV, Hansen, Anne Lindblom, Arto Mannermaa, Humphreys, K, Margolin, S., Heikkinen, Tuomas, Ko, Yon Dschun, García-Closas, Montserrat, Fletcher, O., Flyger, H., Travis, Brandon Reed, Southey, MC, Aittomäki, Kristiina, Zalutsky, I.V., Reiner Strick, Elliott, G, Waltes, R, Nevanlinna, H., Fergus J. Couch, Schmutzler, Rita K., Orr, Nick; id_orcid, Nick Orr, English, Dallas R, van 't Veer, LJ (Laura), Guillermo Pita, Severi, Gianluca, English, DR, Yoo, Keun Young, Kosma, VM, Garcia-Closas, M, Pharoah, Paul D P, Seynaeve, Caroline, Shan Wang-Gohrke, Van't Veer, Laura J, Graham G. Giles, dos Santos Silva, I., Devilee, P., Nordestgaard, Børge G, Antonenkova, Natalia N., Peter A. Fasching, Czene, K., Paul D.P. Pharoah, Bremer, Michael, Platte, R, Maranian, Melanie, Silva, ID, Chanock, S, Maranian, M., Fletcher, Olivia, Shahana Ahmed, Burwinkel, Barbara, Humphreys, M.K., Southey, Melissa C, Pharoah, PDP, Antonenkova, Natalia N, Flyger, H, Margolin, S, Matthias W. Beckmann, Alfons Meindl, Mannermaa, A, Schmutzler, Rita K, Noh, Dong Young, Tollenaar, R.A.E.M., Dork, T, Cox, A., Nevanlinna, H, Bartram, Claus R, van Asperen, C.J., Kosma, Veli Matti, Ahmed, S (Shahana), Mannermaa, Arto, Easton, D.F., Chang-Claude, Jenny, Lissowska, Jolanta, Peter Schürmann, Ko, Y.D., Xianshu Wang, Brock, Ian, Silva, I.D., Chenevix-Trench, G., Kataja, V., Maranian, M, Humphreys, Keith, Fasching, Peter A, Regina Waltes, Fredericksen, Zachary, Gianluca Severi, Blomqvist, C., Letitia Smith, Bartram, C.R., kConFab Investigators +423 morecore +1 more sourceMITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson +13 morewiley +1 more sourceFamily history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls. [PDF]
, 2009 If breast cancers arise independently in each breast the odds ratio (OR) for bilateral breast cancer for carriers of CHEK2 1100delC should be approximately 5.5, the square of the reported OR for a first primary (OR, 2.34).Blomqvist, Carl,, Blomqvist, Carl, Peto, Julian, Muhammad U. Rashid, Johnson, Nichola, Fletcher, Olivia, Chekmariova, Elena V., Anna P. Sokolenko, Broeks, Annegien, Kristiina Aittomäki, Christina Justenhoven, Wasielewski, Marijke, Justenhoven, Christina, Alan Ashworth, Heli Nevanlinna, Ute Hamann, Annegien Broeks, Evgeny N. Imyanitov, Schmidt, Marjanka K., Dörk, Thilo, Michael Bremer, Isabel dos Santos Silva, Imyanitov, Evgeny N., Imyanitov, Evgeny N, Carl Blomqvist, Aittomäki, Kristiina, Rashid, Muhammad U., Kilpivaara, Outi, Laura J. Van't Veer, Hiltrud Brauch, Nichola Johnson, van't Veer, Laura J., Outi Kilpivaara, Nevanlinna, Heli, Ashworth, Alan, Hanne Meijers-Heijerboer, Sokolenko, Anna P, Rashid, Muhammad U, Chekmariova, Elena V, Dos Santos Silva, Isabel, Brauch, Hiltrud, Van't Veer, Laura J, Marijke Wasielewski, Sokolenko, Anna P., Thilo Dörk, Olivia Fletcher, Meijers-Heijerboer, Hanne, Schmidt, Marjanka K, Elena V. Chekmariova, Marjanka K. Schmidt, Julian Peto, Bremer, Michael, Hamann, Ute +52 morecore +1 more source
