Results 21 to 30 of about 406,491 (336)

Research progress of single-cell sequencing in neoadjuvant chemotherapy for triple-negative breast cancer [PDF]

Zhongguo aizheng zazhi, 2021
Triple-negative breast cancer is the most invasive and malignant type of breast cancer. At present, therapy for triple-negative breast cancer is the comprehensive treatment regimens based on chemotherapy, in which neoadjuvant chemotherapy plays an ...
HU Xi’e , YANG Zhenyu , XUE Jingyi , YANG Ping , PENG Shujia , YUAN Lijuan , BAO Guoqiang
doaj   +1 more source

Impact of breast cancer subtypes on 3-year survival among adolescent and young adult women. [PDF]

, 2013
IntroductionYoung women have poorer survival after breast cancer than do older women. It is unclear whether this survival difference relates to the unique distribution of hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2)-defined ...
Clarke, Christina A, DeRouen, Mindy C, Gomez, Scarlett L, Keegan, Theresa HM, Kurian, Allison W, Press, David J, Tao, Li   +6 more
core   +2 more sources

Recent advances in therapeutic strategies for triple-negative breast cancer

Journal of Hematology & Oncology, 2022
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Current treatment options are limited to surgery, adjuvant chemotherapy and radiotherapy; however, a proportion of patients have missed the ...
Yun R Li, Huajun Zhang, Yulia Merkher, Lin Chen, Na Liu, S. Leonov, Yongheng Chen   +6 more
semanticscholar   +1 more source

Avoidance and Period-Shortening of Neoadjuvant Chemotherapy Against Triple-Negative Breast Cancer in Stages I and II: Importance of Ki-67 Labeling Index and the Recognition of Apocrine-Type Lesions

Technology in Cancer Research & Treatment, 2020
Background: Triple-negative breast cancer encompasses heterogeneous subtypes. Neoadjuvant chemotherapy is ineffective against some triple-negative breast cancers, while others show a favorable prognosis despite chemoresistance.
Koichi Kubouchi MD, Kyosuke Shimada MD, Takamichi Yokoe MD, Yutaka Tsutsumi MD   +3 more
doaj   +1 more source

MicroRNAs expression in triple negative vs non triple negative breast cancer in Tunisia: interaction with clinical outcome. [PDF]

PLoS ONE, 2014
MicroRNAs are small, non coding regulatory molecules containing approximately 21 to 25 nucleotides. They function as controllers of expression at post transcriptional levels of most human protein-coding genes and play an essential role in cell signaling ...
Imen Medimegh, Ines Omrane, Maud Privat, Nancy Uhrhummer, Hajer Ayari, Fadoua Belaiba, Farhat Benayed, Khaled Benromdhan, Sylvie Mader, Ives-Jean Bignon, Amel Benammar Elgaaied   +10 more
doaj   +1 more source

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. [PDF]

, 2016
Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-
Brown, Powel H, Chang, Jenny, Den Hollander, Petra, Fuqua, Suzanne, Hartman, Zachary C, Hill, Jamal, Hilsenbeck, Susan G, Kent Osborne, C, Mazumdar, Abhijit, Mills, Gordon B, Poage, Graham M, Shepherd, Jonathan, Tsimelzon, Anna, Zhang, Yun   +13 more
core   +2 more sources

MicroRNAs and Triple Negative Breast Cancer [PDF]

International Journal of Molecular Sciences, 2013
Triple Negative Breast Cancer (TNBC) is a very aggressive tumor subtype, which still lacks specific markers for an effective targeted therapy. Despite the common feature of negativity for the three most relevant receptors (ER, PgR and HER2), TNBC is a very heterogeneous disease where different subgroups can be recognized, and both gene and microRNA ...
D’Ippolito, Elvira, Iorio, Marilena V.
openaire   +2 more sources

Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer.

Cancer Cell, 2021
In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize single-cell RNA- and ATAC-sequencing to examine the immune cell dynamics in 22 patients with advanced TNBC ...
Yuanyuan Zhang, Hongyan Chen, H. Mo, Xueda Hu, Ranran Gao, Yahui Zhao, Baolin Liu, L. Niu, Xiaoying Sun, Xiao Yu, Yong Wang, Q. Chang, T. Gong, X. Guan, T. Hu, T. Qian, Bing-he Xu, F. Ma, Zemin Zhang, Zhihua Liu   +19 more
semanticscholar   +1 more source

Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]

, 2014
Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
core   +1 more source

Treatment of thrice-negative breast cancer in a patient with metabolic syndrome

Исследования и практика в медицине, 2021
Breast cancer (BC) remains one of the most common diseases of the female population. According to statistics, breast cancer is detected in every eighth woman. Approximately 20‑24% of breast cancer patients are diagnosed with triple negative breast cancer.
G. E. Roitberg, J. V. Dorosh, O. Yu. Anikeeva   +2 more
doaj   +1 more source