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International Journal of Breast Cancer, 2012 Ever since the seminal work that was published by Perou et al., triple-negative breast cancer (TNBC) has become a common lexicon among clinicians who care for patients with breast cancer. Beside portending a poor outcome, TNBC is unique in that, unlike the hormone-positive and Her-2-positive cancer cells, it lacks target specific therapy.
Quyen D. Chu, Tari King, Thelma Hurd
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Triple Negative Breast Cancer [PDF]
Klinicka onkologie, 2015 In the Czech Republic, around 6,500 women get breast cancer each year; out of this number, nearly 1,000 women are triple negative subtype. Triple negative breast cancer is characterized by lack of expression of α-estrogen, progesterone, and HER2 receptors.
J, Navrátil +5 more
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Immunotherapy for Triple-Negative Breast Cancer [PDF]
Pharmaceutics, 2021 Triple-negative breast cancer (TNBC) is characterized by extensive tumor heterogeneity at both the pathologic and molecular levels, particularly accelerated aggressiveness, and terrible metastasis. It is responsible for the increased mortality of breast cancer patients.
Yifeng Cao +4 more
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Theranostics for Triple-Negative Breast Cancer
Diagnostics, 2023 Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis. Current endocrine therapy or anti HER-2 therapy is not available for these patients. Chemotherapeutic treatment response varies among patients due to the disease heterogeneity. To overcome these challenges, theranostics for treating TNBC have been widely
Hyeryeon Choi, Kwangsoon Kim
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Characteristics of triple-negative breast cancer [PDF]
Journal of Cancer Research and Clinical Oncology, 2010 Triple-negative breast cancers (TNBC) neither express hormone receptors, nor overexpress HER2. They are associated with poor prognosis, as defined by low five-year survival and high recurrence rates after adjuvant therapy. Overall, TNBC share striking similarities with basal-like breast cancers (BBC), so a number of studies considered them being the ...
de Ruijter, Tim C. +4 more
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MicroRNAs and Triple Negative Breast Cancer [PDF]
International Journal of Molecular Sciences, 2013 Triple Negative Breast Cancer (TNBC) is a very aggressive tumor subtype, which still lacks specific markers for an effective targeted therapy. Despite the common feature of negativity for the three most relevant receptors (ER, PgR and HER2), TNBC is a very heterogeneous disease where different subgroups can be recognized, and both gene and microRNA ...
D’Ippolito, Elvira, Iorio, Marilena V.
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MicroRNAs expression in triple negative vs non triple negative breast cancer in Tunisia: interaction with clinical outcome. [PDF]
PLoS ONE, 2014 MicroRNAs are small, non coding regulatory molecules containing approximately 21 to 25 nucleotides. They function as controllers of expression at post transcriptional levels of most human protein-coding genes and play an essential role in cell signaling ...
Imen Medimegh +10 more
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Treatment of thrice-negative breast cancer in a patient with metabolic syndrome
Исследования и практика в медицине, 2021 Breast cancer (BC) remains one of the most common diseases of the female population. According to statistics, breast cancer is detected in every eighth woman. Approximately 20‑24% of breast cancer patients are diagnosed with triple negative breast cancer.
G. E. Roitberg +2 more
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Asian Pacific Journal of Cancer Prevention, 2014 Triple-negative breast cancers (TNBC), characterized by absence of the estrogen receptor (ER) and progesterone receptor (PR) and lack of overexpression of human epidermal growth factor receptor 2 (HER2), have a poor prognosis. To overcome therapy limitations of TNBC, various new approaches are needed.
Idil, Cetin, Mehmet, Topcul
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Research progress of single-cell sequencing in neoadjuvant chemotherapy for triple-negative breast cancer [PDF]
Zhongguo aizheng zazhi, 2021 Triple-negative breast cancer is the most invasive and malignant type of breast cancer. At present, therapy for triple-negative breast cancer is the comprehensive treatment regimens based on chemotherapy, in which neoadjuvant chemotherapy plays an ...
HU Xi’e , YANG Zhenyu , XUE Jingyi , YANG Ping , PENG Shujia , YUAN Lijuan , BAO Guoqiang
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