Results 61 to 70 of about 469,202 (307)

Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy

Journal of Nanobiotechnology
Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and recurrence, along with a low sensitivity to immunotherapy, resulting in a paucity of effective therapeutic strategies.
Bangyi Zhou, Mengyao Chen, Zhixing Hao, Lili Li, Yixin Zhang, Baoru Fang, Miner Shao, Guohong Ren, Ke Wang, Huiying Liu, Jingxuan Zhu, Xinyi Zhang, Shuyan Yuan, I Sitou, Jing Zhao, Jian Huang, Zhangsen Yu, Fuming Qiu   +17 more
doaj   +1 more source

The current advances of lncRNAs in breast cancer immunobiology research

Frontiers in Immunology, 2023
Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer-related death in women worldwide. Breast cancer development and progression are mainly associated with tumor-intrinsic alterations in diverse genes and signaling ...
Marco Antonio Fonseca-Montaño, Marco Antonio Fonseca-Montaño, Karla Itzel Vázquez-Santillán, Alfredo Hidalgo-Miranda   +3 more
doaj   +1 more source

Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System. [PDF]

, 2018
Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of
Avanzi, Mauro P, Brentjens, Renier J, Cheung, Kenneth, Daniyan, Anthony F, Li, Xinghuo, Park, Hyebin, Purdon, Terence J, Spitzer, Matthew H, van Leeuwen, Dayenne G, Wijewarnasuriya, Dinali P, Yeku, Oladapo   +10 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]

, 2018
The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B., Hodgson, Joseph A., Parvy, Jean-Philippe   +2 more
core   +7 more sources

Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer

Journal of Translational Medicine
Background T cells play a pivotal role in chemotherapy-triggered anti-tumor effects. Emerging evidence underscores the link between impaired anti-tumor immune responses and resistance to paclitaxel therapy in triple-negative breast cancer (TNBC).
Yu Hu, Xiaohan Lou, Kaili Zhang, Longze Pan, Yueyue Bai, Linlin Wang, Ming Wang, Yan Yan, Jiajia Wan, Xiaohan Yao, Xixi Duan, Chen Ni, Zhihai Qin   +12 more
doaj   +1 more source

Tumor Immune Microenvironment and Its Related miRNAs in Tumor Progression

Frontiers in Immunology, 2021
MiRNA is a type of small non-coding RNA, by regulating downstream gene expression that affects the progression of multiple diseases, especially cancer.
Yingying Xing, Guojing Ruan, Haiwei Ni, Hai Qin, Simiao Chen, Xinyue Gu, Jiamin Shang, Yantong Zhou, Xi Tao, Lufeng Zheng   +9 more
doaj   +1 more source

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer. [PDF]

, 2014
BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood.
Amling, Christopher L, Carroll, Peter, Chan, Stephen, Corman, John, Fong, Lawrence, Frohlich, Mark W, Lewis, Jera, Sheikh, Nadeem A, Simko, Jeffrey, Sims, Robert B, Small, Eric J, Stephenson, Robert A, Weinberg, Vivian   +12 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma

Frontiers in Genetics
IntroductionSmall nucleolar RNA (snoRNA) mediates RNA modifications, including 2′-O-methylation (Nm) and pseudouridine (Ψ), which has been proven to impact tumor progression.
Minglu Zhang, Minglu Zhang, Minglu Zhang, Minglu Zhang, Jianbo He, Jianbo He, Jianbo He, Jianbo He, Rao Fu, Rao Fu, Rao Fu, Rao Fu, Guojian Bao, Guojian Bao, Guojian Bao, Yijun Lu, Yijun Lu, Yijun Lu, Zechuan Zhang, Zechuan Zhang, Zechuan Zhang, Jiawu Yan, Jiawu Yan, Jiawu Yan, Jialu Ding, Jialu Ding, Jialu Ding, Fei Yang, Fei Yang, Fei Yang, Fei Yang, Beicheng Sun, Beicheng Sun, Beicheng Sun, Beicheng Sun   +34 more
doaj   +1 more source