Results 61 to 70 of about 368,090 (311)

Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment

, 2022
SIMPLE SUMMARY: Cancers have regions of low oxygen concentration where hypoxia-related signaling pathways are activated. The hypoxic tumor microenvironment has been widely accepted as a hallmark of cancer and shown to be a critical factor in the ...
Yoo, Seongkyeong, In-San Kim, Seongkyeong Yoo, Kim, Iljin, Choi, Sanga, Lee, Mingyu, Kim, In-San, Iljin Kim, Mingyu Lee, Sanga Choi   +9 more
core   +1 more source

The current advances of lncRNAs in breast cancer immunobiology research

Frontiers in Immunology, 2023
Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer-related death in women worldwide. Breast cancer development and progression are mainly associated with tumor-intrinsic alterations in diverse genes and signaling ...
Marco Antonio Fonseca-Montaño, Marco Antonio Fonseca-Montaño, Karla Itzel Vázquez-Santillán, Alfredo Hidalgo-Miranda   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer

Journal of Translational Medicine
Background T cells play a pivotal role in chemotherapy-triggered anti-tumor effects. Emerging evidence underscores the link between impaired anti-tumor immune responses and resistance to paclitaxel therapy in triple-negative breast cancer (TNBC).
Yu Hu, Xiaohan Lou, Kaili Zhang, Longze Pan, Yueyue Bai, Linlin Wang, Ming Wang, Yan Yan, Jiajia Wan, Xiaohan Yao, Xixi Duan, Chen Ni, Zhihai Qin   +12 more
doaj   +1 more source

Tumor Immune Microenvironment and Its Related miRNAs in Tumor Progression

Frontiers in Immunology, 2021
MiRNA is a type of small non-coding RNA, by regulating downstream gene expression that affects the progression of multiple diseases, especially cancer.
Yingying Xing, Guojing Ruan, Haiwei Ni, Hai Qin, Simiao Chen, Xinyue Gu, Jiamin Shang, Yantong Zhou, Xi Tao, Lufeng Zheng   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma

Frontiers in Genetics
IntroductionSmall nucleolar RNA (snoRNA) mediates RNA modifications, including 2′-O-methylation (Nm) and pseudouridine (Ψ), which has been proven to impact tumor progression.
Minglu Zhang, Minglu Zhang, Minglu Zhang, Minglu Zhang, Jianbo He, Jianbo He, Jianbo He, Jianbo He, Rao Fu, Rao Fu, Rao Fu, Rao Fu, Guojian Bao, Guojian Bao, Guojian Bao, Yijun Lu, Yijun Lu, Yijun Lu, Zechuan Zhang, Zechuan Zhang, Zechuan Zhang, Jiawu Yan, Jiawu Yan, Jiawu Yan, Jialu Ding, Jialu Ding, Jialu Ding, Fei Yang, Fei Yang, Fei Yang, Fei Yang, Beicheng Sun, Beicheng Sun, Beicheng Sun, Beicheng Sun   +34 more
doaj   +1 more source

Androgen Receptor in Breast Cancer: From Bench to Bedside

Frontiers in Endocrinology, 2020
Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related mortality in women. Androgen receptor (AR) is frequently expressed in diverse BC subtypes.
Mengyao Chen, Mengyao Chen, Mengyao Chen, Yunben Yang, Yunben Yang, Yunben Yang, Kai Xu, Lili Li, Lili Li, Lili Li, Jian Huang, Jian Huang, Jian Huang, Fuming Qiu, Fuming Qiu, Fuming Qiu   +15 more
doaj   +1 more source

Tumor Microenvironment in Pancreatic Intraepithelial Neoplasia

, 2021
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors with a poor prognosis. A characteristic of PDAC is the formation of an immunosuppressive tumor microenvironment (TME) that facilitates bypassing of the immune surveillance.
Friederike V. Opitz, Lena Haeberle, Irene Esposito, Alexandra Daum   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source