Results 51 to 60 of about 332,900 (265)

Immune aspects of the breast tumor microenvironment [PDF]

Breast Cancer Management, 2013
The immune response in the tumor microenvironment is complex, consisting of cells from both the adaptive and innate immune systems. The phenotype and function of these cells are dictated by cytokines present in the microenvironment, as well as by the interactions of these cells with the tumor cells and each other.
Akhil, Chawla, Gheath, Alatrash, Yun, Wu, Elizabeth A, Mittendorf   +3 more
openaire   +2 more sources

Advances in technology and applications of nanoimmunotherapy for cancer

Biomarker Research, 2021
Host-tumor immune interactions play critical roles in the natural history of tumors, including oncogenesis, progress and metastasis. On the one hand, neoantigens have the potential to drive a tumor-specific immune response.
Lei Dou, Xiangdan Meng, Huiyuan Yang, Haifeng Dong   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Organoid Modeling of the Tumor Immune Microenvironment [PDF]

Cell, 2018
In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes (TILs) as a cohesive unit has been particularly ...
James T, Neal, Xingnan, Li, Junjie, Zhu, Valeria, Giangarra, Caitlin L, Grzeskowiak, Jihang, Ju, Iris H, Liu, Shin-Heng, Chiou, Ameen A, Salahudeen, Amber R, Smith, Brian C, Deutsch, Lillian, Liao, Allison J, Zemek, Fan, Zhao, Kasper, Karlsson, Liora M, Schultz, Thomas J, Metzner, Lincoln D, Nadauld, Yuen-Yi, Tseng, Sahar, Alkhairy, Coyin, Oh, Paula, Keskula, Daniel, Mendoza-Villanueva, Francisco M, De La Vega, Pamela L, Kunz, Joseph C, Liao, John T, Leppert, John B, Sunwoo, Chiara, Sabatti, Jesse S, Boehm, William C, Hahn, Grace X Y, Zheng, Mark M, Davis, Calvin J, Kuo   +33 more
openaire   +2 more sources

Traditional Chinese Medicine's "Yipingweiqi" Adjusts Homeostasis of Tumor Immune Microenvironment

Zhongliu Fangzhi Yanjiu, 2023
Tumor immune microenvironment has been the focus of tumor research in recent years, and its role in tumor regulation has become prominent and has received increasing attention. The imbalance of the tumor immune microenvironment plays an important role in
WANG Runxi, YANG Shuhan, FANG Liyuan, WANG Yan, XIE Yi, LIU Suying, FANG Yuhang, ZHANG Ying   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in human NSCLC

Cell Reports
Summary: CD4+ cytotoxic T lymphocytes (CD4+ CTLs) are suggested to play a crucial role in inflammatory diseases, including cancer, but their characteristics in human non-small cell lung cancer (NSCLC) remain unknown.
Mingjie Lin, Di Chen, Zheyu Shao, Qinyuan Liu, Zhixing Hao, Zhongwei Xin, Yongyuan Chen, Wenxuan Wu, Xiaoke Chen, Teng He, Dang Wu, Pin Wu   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Chronic Stress‐Induced and Tumor Derived SP1+ Exosomes Polarizing IL‐1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer

Advanced Science
Chronic stress can significantly promote breast cancer progression. When exposed to chronic stress, exosomes released from neural and neuroendocrine cells in the central nervous system are enhanced and modified.
Leyi Zhang, Jun Pan, Meijun Wang, Jini Yang, Sangsang Zhu, Lili Li, Xiaoxiao Hu, Zhen Wang, Liwei Pang, Peng Li, Fang Jia, Guohong Ren, Yi Zhang, Danying Xu, Fuming Qiu, Jian Huang   +15 more
doaj   +1 more source

Non-immune Cell Components in the Gastrointestinal Tumor Microenvironment Influencing Tumor Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
Interactions of genetic susceptibility factors, immune microenvironment, and microbial factors contribute to gastrointestinal tumorigenesis. The suppressive immune microenvironment reshaped by the tumors during gastrointestinal tumorigenesis directly ...
Zhengshuo Li, Zhengshuo Li, Zhengshuo Li, Zhengshuo Li, Xiaoyue Zhang, Xiaoyue Zhang, Xiaoyue Zhang, Can Liu, Can Liu, Can Liu, Jian Ma, Jian Ma, Jian Ma, Jian Ma   +13 more
doaj   +1 more source