Results 31 to 40 of about 368,090 (311)

Multiomics technologies for comprehensive tumor microenvironment analysis in triple-negative breast cancer under neoadjuvant chemotherapy

Frontiers in Oncology, 2023
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes and is characterized by abundant infiltrating immune cells within the microenvironment. As standard care, chemotherapy remains the fundamental neoadjuvant treatment
Gang Wang, Yao Yao, Yao Yao, Yao Yao, Huanhuan Huang, Huanhuan Huang, Huanhuan Huang, Jun Zhou, Chao Ni, Chao Ni, Chao Ni   +10 more
doaj   +1 more source

Modulation of innate immunity in the tumor microenvironment [PDF]

Cancer Immunology, Immunotherapy, 2016
A recent report from the Center for Disease Control identified melanoma as being among the highest causes of cancer-related mortalities in the USA. While interventions such as checkpoint blockade have made substantial impact in terms of improving response rates and overall survival, a significant number of patients fail to respond to treatment or ...
Elena, Gonzalez-Gugel, Mansi, Saxena, Nina, Bhardwaj   +2 more
openaire   +2 more sources

Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses

, 2022
In contrast to surgical excision, chemotherapy or radiation therapy, immune checkpoint blockade therapies primarily influence cells in the tumor microenvironment, especially the tumor-associated lymphocytes and antigen-presenting cells.
Priscilla S. Briquez, Heidi Braumüller, Maximilian Rentschler, Thomas Wieder   +3 more
core   +1 more source

Systemic Immune Dysregulation Correlates With Clinical Features of Early Non-Small Cell Lung Cancer

Frontiers in Immunology, 2022
BackgroundSystemic immune dysregulation correlates with cancer progression. However, the clinical implications of systemic immune dysregulation in early non-small cell lung cancer (NSCLC) remain unclear.MethodsUsing a panel of 9 markers to identify 12 ...
Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Feng Du, Zhongwei Xin, Zhongwei Xin, Dang Wu, Dang Wu, Qun Yu, Yimin Wu, Zhouyu Zhu, Wenshan Li, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Ying Chai, Shenghang Jin, Shenghang Jin, Pin Wu, Pin Wu   +21 more
doaj   +1 more source

Immune Cells in the Tumor Microenvironment of Soft Tissue Sarcomas

, 2023
Soft tissue sarcomas (STSs) are a rare heterogeneous group of malignant neoplasms characterized by their aggressive course and poor response to treatment. This determines the relevance of research aimed at studying the pathogenesis of STSs. By now, it is
Timur Fatkhudinov, Enar Jumaniyazova, Anastasiya Lokhonina, Dzhuliia Dzhalilova, Anna Kosyreva   +4 more
core   +1 more source

Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas

, 2023
Gliomas are the most common primary brain malignancy and are universally fatal. Despite significant breakthrough in understanding tumor biology, treatment breakthroughs have been limited.
Mustafa Khasraw, Kelly M. Hotchkiss, Alexander Yuile, Aditya A. Mohan, Joe Q. Wei   +4 more
core   +1 more source

The role of the microenvironment in tumor immune surveillance [PDF]

Bioinformation, 2011
The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O'Shea & Paul, 2010 [4]).
Oluwadara, Oluwadayo, Giacomelli, Luca, Brant, Xenia, Christensen, Russell, Avezova, Raisa, Kossan, George, Chiappelli, Francesco   +6 more
openaire   +4 more sources

NMI: a potential biomarker for tumor prognosis and immunotherapy

Frontiers in Pharmacology, 2022
N-Myc and STAT Interactor protein (NMI) is an interferon inducible protein participating in various cellular activities, and is widely involved in the process of tumorigenesis and progression.
Teng He, Yinbiao Qiao, Qi Yang, Jie Chen, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Zheyu Shao, Zheyu Shao, Pin Wu, Pin Wu, Feng Xu   +16 more
doaj   +1 more source

Engineering the tumor microenvironment of colorectal cancer [PDF]

, 2014
The tumor microenvironment contributes significantly to the clinical prognosis, especially in CRC. Infiltration by cells from the adaptive immune system (e.g. CD8) has been linked to a better survival independently of TNM-stage.
Hirt, Christian Kurt
core   +1 more source

Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma

, 2022
Pancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies.
Christine Alewine, Samuel L. Ricci, Palestino Dominguez, Mayrel, Nebojsa Skorupan, Mayrel Palestino Dominguez, Alewine, Christine, Ricci, Samuel L., Skorupan, Nebojsa   +7 more
core   +1 more source