Results 11 to 20 of about 368,090 (311)
Immunotherapy: Reshape the Tumor Immune Microenvironment
Frontiers in Immunology, 2022 Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc. The interactions between these components, which are divided into anti-tumor and pro-tumor, determine the trend of anti-tumor immunity. Although the immune system can
Bingzhe LV +15 more
doaj +5 more sources
Metabolites and Immune Response in Tumor Microenvironments
Cancers, 2023 The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing the levels of macro- and micronutrients and by releasing hormones and cytokines that recruit immunosuppressive immune cells.
Salvatore Cortellino, Valter D. Longo
openaire +3 more sources
Tumor microenvironment-mediated immune tolerance in development and treatment of gastric cancer
Frontiers in Immunology, 2022 Tumor microenvironment is the general term for all non-cancer components and their metabolites in tumor tissue. These components include the extracellular matrix, fibroblasts, immune cells, and endothelial cells.
Yuanda Liu +4 more
doaj +3 more sources
Signal Transduction and Targeted Therapy, 2021 Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests that the tumor immune microenvironment plays a critical role in anti-cancer ...
Tianyu Tang +5 more
doaj +2 more sources
Organoid Modeling of the Tumor Immune Microenvironment [PDF]
Cell, 2018 In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes (TILs) as a cohesive unit has been particularly ...
James T Neal, Xingnan Li, Junjie Zhu
exaly +3 more sources
Tumor immune microenvironment lncRNAs [PDF]
Briefings in Bioinformatics, 2021 AbstractLong non-coding ribonucleic acids (RNAs) (lncRNAs) are key players in tumorigenesis and immune responses. The nature of their cell type-specific gene expression and other functional evidence support the idea that lncRNAs have distinct cellular functions in the tumor immune microenvironment (TIME).
Eun-Gyeong Park +4 more
openaire +2 more sources
The Immune Endocannabinoid System of the Tumor Microenvironment [PDF]
International Journal of Molecular Sciences, 2020 Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory properties of cannabinoids, the endocannabinoid system (ECS) may have an important role in shaping the TME.
Kienzl, Melanie +2 more
openaire +2 more sources
Journal of Experimental & Clinical Cancer Research, 2023 Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan +12 more
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundCirculating tumor cells (CTCs) have been recognized as a sensitive biomarker for breast cancer (BC). This study aimed to comprehensively compare CTC with imaging modalities, including ultrasonography, mammography, and contrast-enhanced magnetic
Xuan Shao +22 more
doaj +1 more source
Role of Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy
Frontiers in Pharmacology, 2021 Accumulating evidence showed that cancer stem cells (CSCs) play significant roles in cancer initiation, resistance to therapy, recurrence and metastasis. Cancer stem cells possess the ability of self-renewal and can initiate tumor growth and avoid lethal
Jianming Hu +13 more
doaj +1 more source