Results 11 to 20 of about 332,900 (265)

Tumor immune microenvironment lncRNAs [PDF]

Briefings in Bioinformatics, 2021
AbstractLong non-coding ribonucleic acids (RNAs) (lncRNAs) are key players in tumorigenesis and immune responses. The nature of their cell type-specific gene expression and other functional evidence support the idea that lncRNAs have distinct cellular functions in the tumor immune microenvironment (TIME).
Eun-Gyeong Park, Sung-Jin Pyo, Youxi Cui, Sang-Ho Yoon, Jin-Wu Nam   +4 more
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Pyroptosis, metabolism, and tumor immune microenvironment [PDF]

Clinical and Translational Medicine, 2021
AbstractIn response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic ...
Tiantian Du, Jie Gao, Peilong Li, Yunshan Wang, Qiuchen Qi, Xiaoyan Liu, Juan Li, Chuanxin Wang, Lutao Du   +8 more
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Vascular Microenvironment, Tumor Immunity and Immunotherapy [PDF]

Frontiers in Immunology, 2021
Immunotherapy holds great promise for treating cancer. Nonetheless, T cell-based immunotherapy of solid tumors has remained challenging, largely due to the lack of universal tumor-specific antigens and an immunosuppressive tumor microenvironment (TME) that inhibits lymphocyte infiltration and activation.
Zachary Lamplugh, Yi Fan
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The Immune Endocannabinoid System of the Tumor Microenvironment [PDF]

International Journal of Molecular Sciences, 2020
Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory properties of cannabinoids, the endocannabinoid system (ECS) may have an important role in shaping the TME.
Kienzl, Melanie, Kargl, Julia, Schicho, Rudolf   +2 more
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Role of the tumor immune microenvironment in tumor immunotherapy (Review)

Oncology Letters, 2021
Tumor immunotherapy is considered to be a novel and promising therapy for tumors and it has recently become a hot research topic. The clinical success of tumor immunotherapy has been notable, but it has been less than totally satisfactory because tumor immunotherapy has performed poorly in numerous patients although it has shown appreciable efficacy in
Zhou, Changsheng, Liu, Qianqian, Xiang, Yi, Gou, Xin, Li, Wengang   +4 more
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Extracellular vesicles in the tumor immune microenvironment

Cancer Letters, 2021
Extracellular vesicles (EVs) have gained significant attention in recent decades as major mediators of intercellular communication that are involved in various essential physiological and pathological processes. They are secreted by almost all cell types and carry bioactive materials, such as proteins, lipids and nucleic acids, that can be transmitted ...
Pei-pei Hou, Hang-zi Chen
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Multiomics technologies for comprehensive tumor microenvironment analysis in triple-negative breast cancer under neoadjuvant chemotherapy

Frontiers in Oncology, 2023
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes and is characterized by abundant infiltrating immune cells within the microenvironment. As standard care, chemotherapy remains the fundamental neoadjuvant treatment
Gang Wang, Yao Yao, Yao Yao, Yao Yao, Huanhuan Huang, Huanhuan Huang, Huanhuan Huang, Jun Zhou, Chao Ni, Chao Ni, Chao Ni   +10 more
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Systemic Immune Dysregulation Correlates With Clinical Features of Early Non-Small Cell Lung Cancer

Frontiers in Immunology, 2022
BackgroundSystemic immune dysregulation correlates with cancer progression. However, the clinical implications of systemic immune dysregulation in early non-small cell lung cancer (NSCLC) remain unclear.MethodsUsing a panel of 9 markers to identify 12 ...
Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Feng Du, Zhongwei Xin, Zhongwei Xin, Dang Wu, Dang Wu, Qun Yu, Yimin Wu, Zhouyu Zhu, Wenshan Li, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Ying Chai, Shenghang Jin, Shenghang Jin, Pin Wu, Pin Wu   +21 more
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Modulation of innate immunity in the tumor microenvironment [PDF]

Cancer Immunology, Immunotherapy, 2016
A recent report from the Center for Disease Control identified melanoma as being among the highest causes of cancer-related mortalities in the USA. While interventions such as checkpoint blockade have made substantial impact in terms of improving response rates and overall survival, a significant number of patients fail to respond to treatment or ...
Elena, Gonzalez-Gugel, Mansi, Saxena, Nina, Bhardwaj   +2 more
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NMI: a potential biomarker for tumor prognosis and immunotherapy

Frontiers in Pharmacology, 2022
N-Myc and STAT Interactor protein (NMI) is an interferon inducible protein participating in various cellular activities, and is widely involved in the process of tumorigenesis and progression.
Teng He, Yinbiao Qiao, Qi Yang, Jie Chen, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Zheyu Shao, Zheyu Shao, Pin Wu, Pin Wu, Feng Xu   +16 more
doaj   +1 more source