Results 21 to 30 of about 332,900 (265)
Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis
Journal for ImmunoTherapy of Cancer, 2021 Background Neutrophils-linked premetastatic niche plays a key role in tumor metastasis, but not much is known about the heterogeneity and diverse role of neutrophils in niche formation.
Ke Wang +17 more
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Monitoring immune responses in the tumor microenvironment [PDF]
Current Opinion in Immunology, 2016 Immune monitoring in the tumor microenvironment allows for important insights into immune mechanisms of response and resistance to various cancer treatments; however clinical challenges exist using current strategies. Significant questions remain regarding monitoring of archival versus fresh tissue, assessment of static versus dynamic markers ...
Jennifer A, Wargo +3 more
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Frontiers in Oncology, 2020 Lung metastasis is one of the leading causes of death in patients with breast cancer. The mechanism of tumor metastasis remains controversial. Recently, the formation of a pre-metastatic niche has been considered a key factor contributing to breast ...
Zhen Wang +24 more
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Frontiers in Genetics, 2021 The lung is one of the most common sites of distant metastasis in breast cancer (BC). Identifying ideal biomarkers to construct a more accurate prediction model than conventional clinical parameters is crucial.
Leyi Zhang +14 more
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The Immune Consequences of Lactate in the Tumor Microenvironment [PDF]
, 2020 The tumor microenvironment consists of complex and dynamic networks of cytokines, growth factors, and metabolic products. These contribute to significant alterations in tissue architecture, cell growth, immune cell phenotype, and function. Increased glycolytic flux is commonly observed in solid tumors and is associated with significant changes in ...
Harmon, Cathal +2 more
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Frontiers in Oncology, 2022 Breast cancer lung metastasis has a high mortality rate and lacks effective treatments, for the factors that determine breast cancer lung metastasis are not yet well understood.
Leyi Zhang +52 more
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Tumor Immune Microenvironment in Gynecologic Cancers
Cancers, 2023 Gynecologic cancers have varying response rates to immunotherapy due to the heterogeneity of each cancer’s molecular biology and features of the tumor immune microenvironment (TIME). This article reviews key features of the TIME and its role in the pathophysiology and treatment of ovarian, endometrial, cervical, vulvar, and vaginal cancer. Knowledge of
Daniel Margul +2 more
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Immune suppressive mechanisms in the tumor microenvironment [PDF]
Current Opinion in Immunology, 2016 Effective immunotherapy, whether by checkpoint blockade or adoptive cell therapy, is limited in most patients by a key barrier: the immunosuppressive tumor microenvironment. Suppression of tumor-specific T cells is orchestrated by the activity of a variety of stromal myeloid and lymphoid cells.
Munn, David H, Bronte, Vincenzo
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Development of Immunotherapy Strategies Targeting Tumor Microenvironment Is Fiercely Ongoing
Frontiers in Immunology, 2022 Tumor immune microenvironment is a very complex system that is influenced by a wide range of factors; in this microenvironment, various immune cells, stromal cells, and cytokines can interact with tumor cells and jointly regulate this complex ecosystem ...
Rilan Bai, Jiuwei Cui
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Fractionated Radiation Therapy for Large and Giant Cavernous Sinus Hemangioma: A Retrospective Study
Frontiers in Neurology, 2020 Purpose: Surgical resection has been traditionally used as a treatment for cavernous sinus hemangioma (CSH). However, this is usually difficult due to tumor vascularity and results in complications especially in large and giant CSH (volume >20 cm3 ...
Zengfeng Xin +9 more
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