Results 21 to 30 of about 469,202 (307)

Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer based on a novel lipid metabolism-related signature

Frontiers in Immunology, 2023
IntroductionLipid metabolic reprogramming is gaining attention as a hallmark of cancers. Recent mounting evidence indicates that the malignant behavior of breast cancer (BC) is closely related to lipid metabolism.
Lesang Shen, Lesang Shen, Lesang Shen, Huanhuan Huang, Huanhuan Huang, Huanhuan Huang, Jiaxin Li, Jiaxin Li, Jiaxin Li, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Yao Yao, Yao Yao, Yao Yao, Jianming Hu, Jianming Hu, Jianming Hu, Jun Zhou, Fengbo Huang, Chao Ni, Chao Ni, Chao Ni   +22 more
doaj   +1 more source

A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk. [PDF]

, 2020
BackgroundTumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single ...
Azizi, Armon, Bejnood, Alborz, Bouchard, Gina, Diehn, Maximilian, Feng, Weiguo, Forgó, Erna, Gentles, Andrew J, Hoang, Chuong D, Hui, Angela Bik-Yu, Jeong, Youngtae, Knowles, David A, Kuong, Amanda, Nair, Ramesh V, Nair, Viswam S, Plevritis, Sylvia K, van de Rijn, Matt, Varma, Sushama, West, Rob, Xu, Yue, Yu, Alice   +19 more
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“γδT Cell-IL17A-Neutrophil” Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy

Frontiers in Immunology, 2021
Angiogenesis is an essential physiological process and hallmark of cancer. Currently, antiangiogenic therapy, mostly targeting the vascular endothelial growth factor (VEGF)/VEGFR2 signaling axis, is commonly used in the clinic for solid tumors.
Zhigang Zhang, Zhigang Zhang, Chenghui Yang, Lili Li, Lili Li, Ying Zhu, Ke Su, Lingyun Zhai, Zhen Wang, Zhen Wang, Jian Huang, Jian Huang, Jian Huang   +12 more
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Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment

Biomarker Research, 2021
Tumor angiogenesis induces local hypoxia and recruits immunosuppressive cells, whereas hypoxia subsequently promotes tumor angiogenesis. Immunotherapy efficacy depends on the accumulation and activity of tumor-infiltrating immune cells (TIICs ...
Wuzhen Chen, Lesang Shen, Jingxin Jiang, Leyi Zhang, Zhigang Zhang, Jun Pan, Chao Ni, Zhigang Chen   +7 more
doaj   +1 more source

Tumor Immune Microenvironment during Epithelial–Mesenchymal Transition [PDF]

Clinical Cancer Research, 2021
Abstract Epithelial–mesenchymal transition (EMT) has been shown to play a critical role in tumor development from initiation to metastasis. EMT could be regarded as a continuum, with intermediate hybrid epithelial and mesenchymal phenotypes having high plasticity. Classical EMT is characterized by the phenotype change of epithelial cells
Mana Taki, Kaoru Abiko, Masayo Ukita, Ryusuke Murakami, Koji Yamanoi, Ken Yamaguchi, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumura, Masaki Mandai   +9 more
openaire   +2 more sources

Tumor immune microenvironment (TIME) to enhance antitumor immunity

European Journal of Medical Research, 2023
AbstractThe tumor microenvironment is a result of dynamic interaction between different cellular and non-cellular components. In its essence it is not a solo performer, but an ensemble of performers that includes cancer cells, fibroblasts, myo-fibroblasts, endothelial cells and immune cells.
Sajin Rajbhandary, Hari Dhakal, Sudip Shrestha   +2 more
openaire   +3 more sources

CD38 Predicts Favorable Prognosis by Enhancing Immune Infiltration and Antitumor Immunity in the Epithelial Ovarian Cancer Microenvironment

Frontiers in Genetics, 2020
The identification of predictive biomarkers and novel targets to optimize immunotherapy strategies for epithelial ovarian cancer (EOC) is urgently needed. CD38 is a multifunctional glycoprotein that acts as an ectoenzyme and immune receptor. However, the
Ying Zhu, Ying Zhu, Zhigang Zhang, Zhigang Zhang, Zhou Jiang, Yang Liu, Yang Liu, Jianwei Zhou   +7 more
doaj   +1 more source

Radiation-induced tumor immune microenvironments and potential targets for combination therapy

Signal Transduction and Targeted Therapy, 2023
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery.
Siyu Guo, Yihan Yao, Yang Tang, Zengfeng Xin, Dang Wu, Chao Ni, Jian Huang, Qichun Wei, Ting Zhang   +8 more
doaj   +1 more source

Multiomics technologies for comprehensive tumor microenvironment analysis in triple-negative breast cancer under neoadjuvant chemotherapy

Frontiers in Oncology, 2023
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes and is characterized by abundant infiltrating immune cells within the microenvironment. As standard care, chemotherapy remains the fundamental neoadjuvant treatment
Gang Wang, Yao Yao, Yao Yao, Yao Yao, Huanhuan Huang, Huanhuan Huang, Huanhuan Huang, Jun Zhou, Chao Ni, Chao Ni, Chao Ni   +10 more
doaj   +1 more source

Immune Tumor Microenvironment in Ovarian Cancer Ascites

International Journal of Molecular Sciences, 2022
Ovarian cancer (OC) has a specific type of metastasis, via transcoelomic, and most of the patients are diagnosed at advanced stages with multiple tumors spread within the peritoneal cavity. The role of Malignant Ascites (MA) is to serve as a transporter of tumor cells from the primary location to the peritoneal wall or to the surface of the peritoneal ...
Diana Luísa Almeida-Nunes, Ana Mendes-Frias, Ricardo Silvestre, Ricardo Jorge Dinis-Oliveira, Sara Ricardo   +4 more
openaire   +3 more sources