Results 21 to 30 of about 354,584 (265)

NMI: a potential biomarker for tumor prognosis and immunotherapy

Frontiers in Pharmacology, 2022
N-Myc and STAT Interactor protein (NMI) is an interferon inducible protein participating in various cellular activities, and is widely involved in the process of tumorigenesis and progression.
Teng He, Yinbiao Qiao, Qi Yang, Jie Chen, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Zheyu Shao, Zheyu Shao, Pin Wu, Pin Wu, Feng Xu   +16 more
doaj   +1 more source

The Immune Endocannabinoid System of the Tumor Microenvironment [PDF]

International Journal of Molecular Sciences, 2020
Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory properties of cannabinoids, the endocannabinoid system (ECS) may have an important role in shaping the TME.
Kienzl, Melanie, Kargl, Julia, Schicho, Rudolf   +2 more
openaire   +2 more sources

Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis

Journal for ImmunoTherapy of Cancer, 2021
Background Neutrophils-linked premetastatic niche plays a key role in tumor metastasis, but not much is known about the heterogeneity and diverse role of neutrophils in niche formation.
Ke Wang, Jian Huang, Zhen Wang, Haijun Wang, Jun Pan, Jun Yan, Zhigang Zhang, Fang Jia, Lili Li, Chenghui Yang, Fuming Qiu, Xiaoyan Jin, Pin Wu, Shanshan Sun, Ke Su, Leyi Zhang, Xiuyan Yu, Xuan Shao   +17 more
doaj   +1 more source

CD62Ldim Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer

Frontiers in Oncology, 2020
Lung metastasis is one of the leading causes of death in patients with breast cancer. The mechanism of tumor metastasis remains controversial. Recently, the formation of a pre-metastatic niche has been considered a key factor contributing to breast ...
Zhen Wang, Zhen Wang, Zhen Wang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Lili Li, Lili Li, Lili Li, Zhigang Zhang, Zhigang Zhang, Jun Pan, Jun Pan, Jun Pan, Ke Su, Ke Su, Ke Su, Wuzhen Chen, Wuzhen Chen, Jinfan Li, Fuming Qiu, Fuming Qiu, Jian Huang, Jian Huang, Jian Huang   +24 more
doaj   +1 more source

Construction of a MicroRNA-Based Nomogram for Prediction of Lung Metastasis in Breast Cancer Patients

Frontiers in Genetics, 2021
The lung is one of the most common sites of distant metastasis in breast cancer (BC). Identifying ideal biomarkers to construct a more accurate prediction model than conventional clinical parameters is crucial.
Leyi Zhang, Leyi Zhang, Leyi Zhang, Jun Pan, Jun Pan, Jun Pan, Zhen Wang, Zhen Wang, Zhen Wang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Jian Huang, Jian Huang, Jian Huang   +14 more
doaj   +1 more source

Multi-Omics Profiling Suggesting Intratumoral Mast Cells as Predictive Index of Breast Cancer Lung Metastasis

Frontiers in Oncology, 2022
Breast cancer lung metastasis has a high mortality rate and lacks effective treatments, for the factors that determine breast cancer lung metastasis are not yet well understood.
Leyi Zhang, Leyi Zhang, Leyi Zhang, Leyi Zhang, Jun Pan, Jun Pan, Jun Pan, Jun Pan, Zhen Wang, Zhen Wang, Zhen Wang, Zhen Wang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Jingxin Jiang, Jingxin Jiang, Jingxin Jiang, Jingxin Jiang, Zhiyuan Zheng, Zhiyuan Zheng, Zhiyuan Zheng, Zhiyuan Zheng, Fang Jia, Fang Jia, Fang Jia, Fang Jia, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Jiahuan Jiang, Jiahuan Jiang, Jiahuan Jiang, Jiahuan Jiang, Ke Su, Ke Su, Ke Su, Ke Su, Guohong Ren, Guohong Ren, Guohong Ren, Guohong Ren, Jian Huang, Jian Huang, Jian Huang, Jian Huang   +52 more
doaj   +1 more source

Organoid Modeling of the Tumor Immune Microenvironment [PDF]

Cell, 2018
In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes (TILs) as a cohesive unit has been particularly ...
James T, Neal, Xingnan, Li, Junjie, Zhu, Valeria, Giangarra, Caitlin L, Grzeskowiak, Jihang, Ju, Iris H, Liu, Shin-Heng, Chiou, Ameen A, Salahudeen, Amber R, Smith, Brian C, Deutsch, Lillian, Liao, Allison J, Zemek, Fan, Zhao, Kasper, Karlsson, Liora M, Schultz, Thomas J, Metzner, Lincoln D, Nadauld, Yuen-Yi, Tseng, Sahar, Alkhairy, Coyin, Oh, Paula, Keskula, Daniel, Mendoza-Villanueva, Francisco M, De La Vega, Pamela L, Kunz, Joseph C, Liao, John T, Leppert, John B, Sunwoo, Chiara, Sabatti, Jesse S, Boehm, William C, Hahn, Grace X Y, Zheng, Mark M, Davis, Calvin J, Kuo   +33 more
openaire   +2 more sources

Fractionated Radiation Therapy for Large and Giant Cavernous Sinus Hemangioma: A Retrospective Study

Frontiers in Neurology, 2020
Purpose: Surgical resection has been traditionally used as a treatment for cavernous sinus hemangioma (CSH). However, this is usually difficult due to tumor vascularity and results in complications especially in large and giant CSH (volume >20 cm3 ...
Zengfeng Xin, Zengfeng Xin, Yihan Yao, Guodi Chen, Liancong Wang, Meibao Shu, Qinghua Lv, Haifeng Yu, Ting Zhang, Ting Zhang   +9 more
doaj   +1 more source

Development of Immunotherapy Strategies Targeting Tumor Microenvironment Is Fiercely Ongoing

Frontiers in Immunology, 2022
Tumor immune microenvironment is a very complex system that is influenced by a wide range of factors; in this microenvironment, various immune cells, stromal cells, and cytokines can interact with tumor cells and jointly regulate this complex ecosystem ...
Rilan Bai, Jiuwei Cui
doaj   +1 more source

Characterization of the Neuroendocrine Tumor Immune Microenvironment [PDF]

Pancreas, 2018
Objectives The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic NETs.
Annacarolina, da Silva, Michaela, Bowden, Sui, Zhang, Yohei, Masugi, Aaron R, Thorner, Zachary T, Herbert, Chensheng Willa, Zhou, Lauren, Brais, Jennifer A, Chan, F Stephen, Hodi, Scott, Rodig, Shuji, Ogino, Matthew H, Kulke   +12 more
openaire   +2 more sources