Results 21 to 30 of about 368,090 (311)

Role of the tumor immune microenvironment in tumor immunotherapy (Review)

Oncology Letters, 2021
Tumor immunotherapy is considered to be a novel and promising therapy for tumors and it has recently become a hot research topic. The clinical success of tumor immunotherapy has been notable, but it has been less than totally satisfactory because tumor immunotherapy has performed poorly in numerous patients although it has shown appreciable efficacy in
Zhou, Changsheng, Liu, Qianqian, Xiang, Yi, Gou, Xin, Li, Wengang   +4 more
openaire   +3 more sources

Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer based on a novel lipid metabolism-related signature

Frontiers in Immunology, 2023
IntroductionLipid metabolic reprogramming is gaining attention as a hallmark of cancers. Recent mounting evidence indicates that the malignant behavior of breast cancer (BC) is closely related to lipid metabolism.
Lesang Shen, Lesang Shen, Lesang Shen, Huanhuan Huang, Huanhuan Huang, Huanhuan Huang, Jiaxin Li, Jiaxin Li, Jiaxin Li, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Yao Yao, Yao Yao, Yao Yao, Jianming Hu, Jianming Hu, Jianming Hu, Jun Zhou, Fengbo Huang, Chao Ni, Chao Ni, Chao Ni   +22 more
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Extracellular vesicles in the tumor immune microenvironment

Cancer Letters, 2021
Extracellular vesicles (EVs) have gained significant attention in recent decades as major mediators of intercellular communication that are involved in various essential physiological and pathological processes. They are secreted by almost all cell types and carry bioactive materials, such as proteins, lipids and nucleic acids, that can be transmitted ...
Pei-pei Hou, Hang-zi Chen
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Pyroptosis, metabolism, and tumor immune microenvironment [PDF]

Clinical and Translational Medicine, 2021
AbstractIn response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic ...
Tiantian Du, Jie Gao, Peilong Li, Yunshan Wang, Qiuchen Qi, Xiaoyan Liu, Juan Li, Chuanxin Wang, Lutao Du   +8 more
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Vascular Microenvironment, Tumor Immunity and Immunotherapy [PDF]

Frontiers in Immunology, 2021
Immunotherapy holds great promise for treating cancer. Nonetheless, T cell-based immunotherapy of solid tumors has remained challenging, largely due to the lack of universal tumor-specific antigens and an immunosuppressive tumor microenvironment (TME) that inhibits lymphocyte infiltration and activation.
Zachary Lamplugh, Yi Fan
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“γδT Cell-IL17A-Neutrophil” Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy

Frontiers in Immunology, 2021
Angiogenesis is an essential physiological process and hallmark of cancer. Currently, antiangiogenic therapy, mostly targeting the vascular endothelial growth factor (VEGF)/VEGFR2 signaling axis, is commonly used in the clinic for solid tumors.
Zhigang Zhang, Zhigang Zhang, Chenghui Yang, Lili Li, Lili Li, Ying Zhu, Ke Su, Lingyun Zhai, Zhen Wang, Zhen Wang, Jian Huang, Jian Huang, Jian Huang   +12 more
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Tumor Immune Microenvironment in Gynecologic Cancers

Cancers, 2023
Gynecologic cancers have varying response rates to immunotherapy due to the heterogeneity of each cancer’s molecular biology and features of the tumor immune microenvironment (TIME). This article reviews key features of the TIME and its role in the pathophysiology and treatment of ovarian, endometrial, cervical, vulvar, and vaginal cancer. Knowledge of
Daniel Margul, Camilla Yu, Mariam M. AlHilli   +2 more
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Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment

Biomarker Research, 2021
Tumor angiogenesis induces local hypoxia and recruits immunosuppressive cells, whereas hypoxia subsequently promotes tumor angiogenesis. Immunotherapy efficacy depends on the accumulation and activity of tumor-infiltrating immune cells (TIICs ...
Wuzhen Chen, Lesang Shen, Jingxin Jiang, Leyi Zhang, Zhigang Zhang, Jun Pan, Chao Ni, Zhigang Chen   +7 more
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CD38 Predicts Favorable Prognosis by Enhancing Immune Infiltration and Antitumor Immunity in the Epithelial Ovarian Cancer Microenvironment

Frontiers in Genetics, 2020
The identification of predictive biomarkers and novel targets to optimize immunotherapy strategies for epithelial ovarian cancer (EOC) is urgently needed. CD38 is a multifunctional glycoprotein that acts as an ectoenzyme and immune receptor. However, the
Ying Zhu, Ying Zhu, Zhigang Zhang, Zhigang Zhang, Zhou Jiang, Yang Liu, Yang Liu, Jianwei Zhou   +7 more
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Radiation-induced tumor immune microenvironments and potential targets for combination therapy

Signal Transduction and Targeted Therapy, 2023
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery.
Siyu Guo, Yihan Yao, Yang Tang, Zengfeng Xin, Dang Wu, Chao Ni, Jian Huang, Qichun Wei, Ting Zhang   +8 more
doaj   +1 more source