Results 81 to 90 of about 469,202 (307)

Influenced tumor microenvironment and tumor immunity by amino acids

Frontiers in Immunology, 2023
It is widely accepted that tumors are a complex tissue composed of cancer cells, extracellular matrix, inflammatory cells, immune cells, and other cells. Deregulation of tumor microenvironment promotes tumor aggressiveness by sustaining cell growth, invasion, and survival from immune surveillance.
Min Yu, Shuang Zhang
openaire   +3 more sources

Non-immune Cell Components in the Gastrointestinal Tumor Microenvironment Influencing Tumor Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
Interactions of genetic susceptibility factors, immune microenvironment, and microbial factors contribute to gastrointestinal tumorigenesis. The suppressive immune microenvironment reshaped by the tumors during gastrointestinal tumorigenesis directly ...
Zhengshuo Li, Zhengshuo Li, Zhengshuo Li, Zhengshuo Li, Xiaoyue Zhang, Xiaoyue Zhang, Xiaoyue Zhang, Can Liu, Can Liu, Can Liu, Jian Ma, Jian Ma, Jian Ma, Jian Ma   +13 more
doaj   +1 more source

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in human NSCLC

Cell Reports
Summary: CD4+ cytotoxic T lymphocytes (CD4+ CTLs) are suggested to play a crucial role in inflammatory diseases, including cancer, but their characteristics in human non-small cell lung cancer (NSCLC) remain unknown.
Mingjie Lin, Di Chen, Zheyu Shao, Qinyuan Liu, Zhixing Hao, Zhongwei Xin, Yongyuan Chen, Wenxuan Wu, Xiaoke Chen, Teng He, Dang Wu, Pin Wu   +11 more
doaj   +1 more source

Editorial: ‘Engineering the Tumor Immune Microenvironment’ Special Issue

Cancers, 2023
Cancer immunotherapies, while promising and occasionally even curative, encounter numerous hurdles within the tumor microenvironment that hinder their efficacy [...]
Raffae N. Ahmad, Scott S. Verbridge
openaire   +2 more sources

Traditional Chinese Medicine's "Yipingweiqi" Adjusts Homeostasis of Tumor Immune Microenvironment

Zhongliu Fangzhi Yanjiu, 2023
Tumor immune microenvironment has been the focus of tumor research in recent years, and its role in tumor regulation has become prominent and has received increasing attention. The imbalance of the tumor immune microenvironment plays an important role in
WANG Runxi, YANG Shuhan, FANG Liyuan, WANG Yan, XIE Yi, LIU Suying, FANG Yuhang, ZHANG Ying   +7 more
doaj   +1 more source

Distinct blood and visceral adipose tissue regulatory T cell and innate lymphocyte profiles characterize obesity and colorectal cancer [PDF]

, 2017
Visceral adipose tissue (VAT) is a main site where metabolic and immunologic processes interplay to regulate, at local and systemic level, the inflammatory status and immune response.
Barbara Varano, Beatrice Scazzocchio, Gloria Donninelli, Ilenia Pacella, Lucia Conti, Manuela Del Cornò, Marina Pierdominici, Massimo D’Archivio, Roberta Masella, Rosaria Varì, Sandra Gessani, Silvia Piconese, Silvia Piconese, Vincenzo Barnaba, Vincenzo Barnaba   +14 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Chronic Stress‐Induced and Tumor Derived SP1+ Exosomes Polarizing IL‐1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer

Advanced Science
Chronic stress can significantly promote breast cancer progression. When exposed to chronic stress, exosomes released from neural and neuroendocrine cells in the central nervous system are enhanced and modified.
Leyi Zhang, Jun Pan, Meijun Wang, Jini Yang, Sangsang Zhu, Lili Li, Xiaoxiao Hu, Zhen Wang, Liwei Pang, Peng Li, Fang Jia, Guohong Ren, Yi Zhang, Danying Xu, Fuming Qiu, Jian Huang   +15 more
doaj   +1 more source