Results 81 to 90 of about 368,090 (311)

Traditional Chinese Medicine's "Yipingweiqi" Adjusts Homeostasis of Tumor Immune Microenvironment

Zhongliu Fangzhi Yanjiu, 2023
Tumor immune microenvironment has been the focus of tumor research in recent years, and its role in tumor regulation has become prominent and has received increasing attention. The imbalance of the tumor immune microenvironment plays an important role in
WANG Runxi, YANG Shuhan, FANG Liyuan, WANG Yan, XIE Yi, LIU Suying, FANG Yuhang, ZHANG Ying   +7 more
doaj   +1 more source

The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment

, 2022
SIMPLE SUMMARY: Tumor microenvironment is a complex and dynamically changing entity, which is crucial for tumor development. Indoleamine 2, 3-dioxygenase 1 is elevated in the tumor microenvironment and is strongly associated with tumor histological ...
Xiaobo Wang, Feng Zhang, Xinting Huang, Ke Liu, Wang, Xiaobo, Huang, Xinting, Liu, Ke, Zhang, Feng   +7 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Chronic Stress‐Induced and Tumor Derived SP1+ Exosomes Polarizing IL‐1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer

Advanced Science
Chronic stress can significantly promote breast cancer progression. When exposed to chronic stress, exosomes released from neural and neuroendocrine cells in the central nervous system are enhanced and modified.
Leyi Zhang, Jun Pan, Meijun Wang, Jini Yang, Sangsang Zhu, Lili Li, Xiaoxiao Hu, Zhen Wang, Liwei Pang, Peng Li, Fang Jia, Guohong Ren, Yi Zhang, Danying Xu, Fuming Qiu, Jian Huang   +15 more
doaj   +1 more source

Tumor immune microenvironment (TIME) to enhance antitumor immunity

European Journal of Medical Research, 2023
AbstractThe tumor microenvironment is a result of dynamic interaction between different cellular and non-cellular components. In its essence it is not a solo performer, but an ensemble of performers that includes cancer cells, fibroblasts, myo-fibroblasts, endothelial cells and immune cells.
Sajin Rajbhandary, Hari Dhakal, Sudip Shrestha   +2 more
openaire   +3 more sources

Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics

, 2022
Lymphoma is a neoplasm arising from B or T lymphocytes or natural killer cells characterized by clonal lymphoproliferation. This tumor comprises a diverse and heterogeneous group of malignancies with distinct clinical, histopathological, and molecular ...
Daniel J. García-Domínguez, Jiménez-Cortegana, Carlos, Sánchez Margalet, Víctor, Carlos Jiménez-Cortegana, Palazón-Carrión, Natalia, Víctor Sánchez-Margalet, Lourdes Hontecillas-Prieto, Cruz Merino, Luis de la, Hontecillas-Prieto, Lourdes, Natalia Palazón-Carrión, García-Domínguez, Daniel J., Luis de la Cruz-Merino, Jiménez Cortegana, Carlos, Hontecillas Prieto, Lourdes, Palazón Carrión, Natalia, de la Cruz-Merino, Luis, García-Domínguez, Daniel J, Sánchez-Margalet, Víctor   +17 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Targeting Cellular Components of the Tumor Microenvironment in Solid Malignancies

, 2022
Cancers are composed of transformed cells, characterized by aberrant growth and invasiveness, in close relationship with non-transformed healthy cells and stromal tissue.
Gabriele Antonarelli, Boscolo Bielo, Luca, Giuseppe Curigliano, Carmen Belli, Luca Boscolo Bielo, Curigliano, Giuseppe, Edoardo Crimini, Repetto, Matteo, Matteo Repetto, Antonarelli, Gabriele, Crimini, Edoardo, Belli, Carmen   +11 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI

Translational Oncology
Objectives: High body mass index (BMI), encompassing overweight and obesity, is a well-established risk factor for developing breast cancer (BC). The underlying mechanisms linking elevated BMI to increased BC risk involve metabolic reprogramming and ...
Xiaoxiao Hu, Fang Jia, Lili Li, Wuzhen Chen, Leyi Zhang, Jun Pan, Sangsang Zhu, Zhen Wang, Jian Huang   +8 more
doaj   +1 more source