Results 91 to 100 of about 368,090 (311)

Heterogeneity of Cancer-Associated Fibroblasts and the Tumor Immune Microenvironment in Pancreatic Cancer

, 2022
SIMPLE SUMMARY: Stroma-targeting therapy in pancreatic ductal adenocarcinoma (PDAC) has been extensively investigated, but no candidates have shown efficacy at the clinical trial stage.
Masafumi Nakamura, Tomohiko Shinkawa, Nakamura, Masafumi, Kenoki Ohuchida, Ohuchida, Kenoki, Shinkawa, Tomohiko   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Metabolism of Immune Cells in the Tumor Microenvironment

, 2021
AbstractThe tumor microenvironment (TME) is a complex biological structure surrounding tumor cells and includes blood vessels, immune cells, fibroblasts, adipocytes, and extracellular matrix (ECM) [1, 2]. These heterogeneous surrounding structures provide nutrients, metabolites, and signaling molecules to provide a cancer-friendly environment.
Jin G, Jung, Anne, Le
openaire   +2 more sources

Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer

, 2022
SIMPLE SUMMARY: The tumor suppressing effect of metformin has been reported, and tumor microenvironment including immune cells contribute to tumor progression in colorectal cancer.
Lee, Kyoung Jin, Lee, Doyeon, Kyoung Jin Lee, Tae Il Kim, Chang, Shin Young, Jae Hee Cheon, Kang, Eun Ae, Jihye Park, Kang, Joyeon, Kim, Tae Il, Park, Jae Jun, Seo, Yoojeong, Park, Soo Jung, Jaepil Eric Yoon, Doyeon Lee, Yoon, Jaepil Eric, Kwon, Ji-Hee, Janghyun Kim, Shin Young Chang, Park, Jihye, Yoojeong Seo, Cheon, Jae Hee, Joyeon Kang, Kim, Janghyun, Jae Jun Park, Ji-Hee Kwon, Soo Jung Park, Eun Ae Kang   +27 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Therapeutic Targeting of Cancer-Associated Fibroblasts in the Non-Small Cell Lung Cancer Tumor Microenvironment

, 2023
Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer death worldwide. The most common lung cancer is non-small cell lung cancer (NSCLC), with an overall 5-year survival rate of around 20% because NSCLC is a metastatic ...
Yasushi Shintani, Naoko Ose, Toru Kimura, Takashi Kanou, Eriko Fukui, Soichiro Funaki   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Exploring Prognosis, Tumor Microenvironment and Tumor Immune Infiltration in Hepatocellular Carcinoma Based on ATF/CREB Transcription Factor Family Gene-Related Model

Journal of Hepatocellular Carcinoma, 2023
Honghong Shen,1,* Xianhua Gu,2,* Huiyuan Li,1 Mingyue Tang,1 Xinwei Li,1 Yue Zhang,1 Fang Su,1 Zishu Wang1 1Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, People’s Republic of China; 2Department of ...
Shen H, Gu X, Li H, Tang M, Li X, Zhang Y, Su F, Wang Z   +7 more
doaj  

miR-4666-3p and miR-329 Synergistically Suppress the Stemness of Colorectal Cancer Cells via Targeting TGF-β/Smad Pathway

Frontiers in Oncology, 2019
Quiescent caner stem cells are identified as a subpopulation of colon cancer cells in dormant state and possess strong stem-cell like characteristics.
Jun Ye, Jiacai Lei, Qingqing Fang, Yimin Shen, Wenjie Xia, Xiaoge Hu, Qiuran Xu, Hongjun Yuan, Jian Huang, Jian Huang, Chao Ni, Chao Ni, Chao Ni   +12 more
doaj   +1 more source

Cancer-Associated Fibroblasts: Master Tumor Microenvironment Modifiers

, 2023
Cancer cells rely on the tumor microenvironment (TME), a composite of non-malignant cells, and extracellular matrix (ECM), for survival, growth, and metastasis. The ECM contributes to the biomechanical properties of the surrounding tissue, in addition to
Andras Czirok, Kellen Wright, Thuc Ly, Sufi Mary Thomas, Matthew Kriet   +4 more
core   +1 more source