Tumor cuproptosis and immune infiltration improve survival of patients with hepatocellular carcinoma with a high expression of ferredoxin 1 [PDF]
Frontiers in Oncology, 2023 BackgroundCuproptosis is a novel cell death pathway dependent on cellular copper ions and ferredoxin 1 (FDX1). Hepatocellular carcinoma (HCC) is derived from healthy liver as a central organ for copper metabolism.
Yingyao Quan +5 more
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Characterization of the functional effects of ferredoxin 1 as a cuproptosis biomarker in cancer [PDF]
Frontiers in Genetics, 2022 Background: Cuproptosis is a recently discovered form of programmed cell death. Ferredoxin 1 (FDX1) is a key gene that mediates this process. However, the role of FDX1 in human tumors is not clear.Methods: We comprehensively analyzed the differential ...
Xiang Li +6 more
doaj +2 more sources
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1 [PDF]
Annals of Medicine, 2023 Excessive oxygen free radicals and toxic substances are generated in cerebral ischemia-reperfusion (I/R) process. Dexmedetomidine (DEX), a common anesthetic and sedative drug, can considerably boost glutathione (GSH), which has anti-copper influx effects.
Qingduo Guo +4 more
doaj +2 more sources
Ferredoxin 1 is essential for embryonic development and lipid homeostasis [PDF]
eLifeMammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways ...
Shakur Mohibi +5 more
doaj +2 more sources
Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis [PDF]
Frontiers in Pharmacology, 2022 Ferredoxin 1 (FDX1) functions by transferring electrons from NADPH to mitochondrial cytochrome P450 via the ferredoxin reductase and is the key regulator in copper-dependent cell death.
Longfei Yang +8 more
doaj +2 more sources
Role of ferredoxin 1 (FDX1) in cancer and its therapeutic potential [PDF]
Cancer Pathogenesis and TherapyFerredoxin 1 (FDX1) is a small iron-sulfur (Fe–S) cluster protein localized to the mitochondria. It functions as an electron carrier in diverse metabolic pathways and is critically involved in the regulation of protein lipoylation Accumulating evidence ...
Fen He +7 more
doaj +2 more sources
Systematic analysis based on the cuproptosis-related genes identifies ferredoxin 1 as an immune regulator and therapeutic target for glioblastoma [PDF]
BMC Cancer, 2023 Glioblastoma multiforme (GBM) is recognized as the prevailing malignant and aggressive primary brain tumor, characterized by an exceedingly unfavorable prognosis.
Lirui Dai +3 more
doaj +2 more sources
Integrated profiling identifies ferredoxin 1 as an immune-related biomarker of malignant phenotype in glioma [PDF]
HeliyonBackground: Glioma, a highly resistant and recurrent type of central nervous system tumor, poses a significant challenge in terms of effective drug treatments and its associated mortality rates.
Dongcheng Xie +11 more
doaj +2 more sources
Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury [PDF]
Scientific ReportsIn the current study, we aimed to investigate whether disulfiram (DSF) exerts a neuroprotective role in cerebral ischemiareperfusion (CI-RI) injury by modulating ferredoxin 1 (FDX1) to regulate copper ion (Cu) levels and inhibiting inflammatory responses.
Shuai Yang +8 more
doaj +2 more sources
Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway [PDF]
Journal of Translational MedicineBackground Lung adenocarcinoma (LUAD) is a highly lethal form of lung cancer. Despite advancements in treatments, managing LUAD is still challenging due to its aggressive behavior.
Ming Liu +6 more
doaj +2 more sources