Results 31 to 40 of about 29,761,483 (233)

Cuproptosis-Related Gene – SLC31A1, FDX1 and ATP7B – Polymorphisms are Associated with Risk of Lung Cancer

Pharmacogenomics and Personalized Medicine, 2022
Yuhui Yun,1,* Yun Wang,2,* Ende Yang,1 Xin Jing1 1Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China; 2Department of Medical Oncology, Tangdu Hospital, The ...
Yun Y, Wang Y, Yang E, Jing X
doaj  

Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer

Journal of Experimental & Clinical Cancer Research, 2023
Introduction Cuproptosis and ferroptosis are the two newly defined metal-related regulated cell death. However, the crosstalk between cuproptosis and ferroptosis is obscure.
Weikai Wang, Kaizhong Lu, Xin Jiang, Qi Wei, Liyuan Zhu, Xian Wang, Hongchuan Jin, Lifeng Feng   +7 more
doaj   +1 more source

In vitro-induction of metronidazole-resistant Giardia duodenalis is not associated with nucleotide alterations in the genes involved in pro-drug activation [PDF]

Memorias do Instituto Oswaldo Cruz, 2020
Giardiasis is an infectious disease caused by Giardia duodenalis. The pro-drug metronidazole (MTZ) is the first-line treatment for giardiasis. Parasite’s proteins as pyruvate:ferredoxin oxidoreductase (PFOR), ferredoxin (Fd), nitroreductase-1 (NR-1) and ...
Luiz Antonio Pimentel Lopes-Oliveira, Maria Fantinatti, Alda Maria Da-Cruz   +2 more
doaj   +1 more source

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +2 more sources

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Substrate‐Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis

Angewandte Chemie, EarlyView.
Substitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Chandrashekhar Padhi, Dinh T. Nguyen, Lingyang Zhu, Lide Cha, Jesse W. Wald, Douglas A. Mitchell, Wilfred A. van der Donk   +6 more
wiley   +2 more sources

The interaction of ferredoxin-linked sulfite reductase with ferredoxin [PDF]

, 1987
Spinach sulfite reductase has been shown to co-migrate during gel filtration chromatography at low ionic strength with spinach ferredoxin. No co-migration was observed at high ionic strength.
Danny J. Davis, J.Milton Boyer, Knaff, David B., Hirasawa, Masakazu, Gray, Kevin A., Davis, Danny J., Masakazu Hirasawa, Boyer, J.Milton, Kevin A. Gray, David B. Knaff   +9 more
core   +1 more source

ferredoxin-like peptide ARB output.nex

, 2013
ferredoxin-like peptide ARB output ...
Leadbetter, Jared R., Lucey, Kaitlyn S., Kaitlyn S. Lucey (3315138), Jared R. Leadbetter (223388)   +3 more
core   +1 more source

Gain‐of‐Function Engineering of the NifEN Scaffold Into a Self‐Assembling Nitrogenase

Angewandte Chemie, EarlyView.
From scaffold to enzyme: Systematic engineering of the cofactor maturation scaffold NifEN reconstructs the P→M electron relay along with cofactor coordination and proton gating at the S2B site, converting NifEN into a functional nitrogenase capable of ATP‐dependent N2 reduction both in vitro and in vivo.
Yimo Yang, Chi Chung Lee, Steve Ortiz, Markus W. Ribbe, Yilin Hu   +4 more
wiley   +2 more sources

Nicotiana tabacum Tsip1-Interacting Ferredoxin 1 Affects Biotic and Abiotic Stress Resistance [PDF]

Molecules and Cells, 2012
Tsip1, a Zn finger protein that was isolated as a direct interactor with tobacco stress-induced 1 (Tsi1), plays an important role in both biotic and abiotic stress signaling. To further understand Tsip1 function, we searched for more Tsip1-interacting proteins by yeast two-hybrid screening using a tobacco cDNA library.
Sung Un, Huh, In-Ju, Lee, Byung-Kook, Ham, Kyung-Hee, Paek   +3 more
openaire   +4 more sources