Results 51 to 60 of about 238 (113)

Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical Giardia lamblia assemblage A and B isolates

Infection and Drug Resistance, 2019
Christina S Saghaug,1,2 Christian Klotz,3 Juha P Kallio,4 Hans-Richard Brattbakk,1,5 Tomasz Stokowy,1,5 Toni Aebischer,3 Inari Kursula,4,6 Nina Langeland,1–2,7 Kurt Hanevik1,21Department of Clinical Science, University of Bergen, Bergen, Hordaland,
Saghaug CS, Klotz C, Kallio JP, Brattbakk HR, Stokowy T, Aebischer T, Kursula I, Langeland N, Hanevik K   +8 more
doaj  

Tobacco Rattle Virus Coat Protein Targets Ferredoxin 1 for Degradation

Molecular Plant Pathology
ABSTRACT Plant virus infections commonly inhibit leaf photosynthesis, leading to characteristic symptoms such as chlorosis. However, whether a conserved mechanism underpins this phenomenon remains unclear. Here, we demonstrate that the coat protein (CP) of tobacco rattle virus (TRV) interacts with
Shaorui Tian, Changyun Liu, Jie Dong, Xin Zhu, Xingyi Luo, Weina Liu, Haoran Peng, Lin Cai, Xianchao Sun   +8 more
openaire   +1 more source

HO1 and PcyA proteins involved in phycobilin biosynthesis form a 1:2 complex with ferredoxin‐1 required for photosynthesis

FEBS Letters, 2009
MINT‐7014675: PcyA (uniprotkb:P59288) and Fd1 (uniprotkb:P0A3C9) bind (MI:0407) by cross‐linking studies (MI:0030)
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The Ferredoxin-Like Proteins HydN and YsaA Enhance Redox Dye-Linked Activity of the Formate Dehydrogenase H Component of the Formate Hydrogenlyase Complex

Frontiers in Microbiology, 2018
Formate dehydrogenase H (FDH-H) and [NiFe]-hydrogenase 3 (Hyd-3) form the catalytic components of the hydrogen-producing formate hydrogenlyase (FHL) complex, which disproportionates formate to H2 and CO2 during mixed acid fermentation in enterobacteria ...
Constanze Pinske
doaj   +1 more source

Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury

Scientific Reports
In the current study, we aimed to investigate whether disulfiram (DSF) exerts a neuroprotective role in cerebral ischemiareperfusion (CI-RI) injury by modulating ferredoxin 1 (FDX1) to regulate copper ion (Cu) levels and inhibiting inflammatory responses.
Shuai Yang, Xudong Li, Jinhong Yan, Fangchao Jiang, Xuehui Fan, Jing Jin, Weihua Zhang, Di Zhong, Guozhong Li   +8 more
doaj   +1 more source

Atractylenolide III mitigates polycystic ovary syndrome by activating FDX1-mediated proliferation of ovarian granulocyte cells via PI3K/AKT/mTOR

Journal of Ovarian Research
Background Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder among women of reproductive age worldwide. This study aimed to investigate the therapeutic potential and molecular mechanisms of Atractylenolide III (ATL-III),
Nan Zhou, Wei Tai, Wenqiang Lv, Qing He, Shiwen He, Kexin Chen, Qing Wang, Jingbo Zhang, Suyan Li, Yijuan Cao, Xueyan Zhou   +10 more
doaj   +1 more source

Hydrogen production in the Chlorella sp. DT mutants carrying heterologous electron donor ferredoxin 1 of Chlamydomonas reinhardtii

Electronic Journal of Biotechnology
Background: Ferredoxin 1 (Fd1) is the main electron donor to hydrogenase (HydA) for generating molecular hydrogen (H2) in green microalgae. In order to obtain an increased H2 production, the Fd1 of Chlamydomonas reinhardtii (CrFd1, encoded by crfd1) was ...
Yen-Ju Lin, Lee-Feng Chien
doaj   +1 more source

Effect of cell permeability and dehydrogenase expression on octane activation by CYP153A6-based whole cell Escherichia coli catalysts

Microbial Cell Factories, 2017
Background The regeneration of cofactors and the supply of alkane substrate are key considerations for the biocatalytic activation of hydrocarbons by cytochrome P450s.
Bronwyn E. White, Caryn J. Fenner, Martha S. Smit, Susan T. L. Harrison   +3 more
doaj   +1 more source

Synthesis, Characterization, and Bioactivity of a Dioxime-Based Copper(II) Complex: SOD/Catalase Mimicry, DNA/HSA Binding, and In Silico Evaluation for Cuproptosis-Mediated Anticancer Activity

Inorganics
Cisplatin’s chemotherapy is hindered by drug resistance and toxicity, making copper complexes a potential alternative. A novel copper(II) complex, [CuLBr], was synthesized from a tetradentate vicinal dioxime ligand (H2L) and characterized.
Mortaga M. Abou-Krisha, Abd El-Motaleb M. Ramadan, Heba A. Sahyon, Ahmed M. Fathy   +3 more
doaj   +1 more source

Hypoxia-induced autophagy attenuates ferredoxin 1-mediated cuproptosis in colorectal cancer cells

Human & Experimental Toxicology
Introduction Cuproptosis has emerged as a potential therapeutic target for colorectal cancer (CRC). This study investigated the role of ferredoxin 1 (FDX1) in regulating cuproptosis under hypoxic conditions and explored the impact of autophagy on this process in CRC.
Long Qin, ZhenBing Lv, BinYu Luo, Jing Yu, Min Li, Rong Jing, JingDong Li   +6 more
openaire   +2 more sources