Results 41 to 50 of about 3,265 (192)

Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis

Frontiers in Pharmacology, 2022
Ferredoxin 1 (FDX1) functions by transferring electrons from NADPH to mitochondrial cytochrome P450 via the ferredoxin reductase and is the key regulator in copper-dependent cell death.
Longfei Yang, Longfei Yang, Yuwei Zhang, Yuwei Zhang, Yang Wang, Peng Jiang, Fengping Liu, Ninghan Feng, Ninghan Feng   +8 more
doaj   +1 more source

FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis

Frontiers in Genetics, 2022
Ferredoxin 1 (FDX1), an iron-sulphur protein, is responsible for electron transfer in a range of metabolic redox reactions. Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer characterised by metabolic reprogramming, and FDX1 is a critical ...
Xing Huang, Xing Huang, Tao Wang, Tao Wang, Jiali Ye, Jiali Ye, Huayi Feng, Huayi Feng, Xiangyi Zhang, Xiangyi Zhang, Xin Ma, Baojun Wang, Yan Huang, Xu Zhang   +13 more
doaj   +1 more source

FDX1 regulates cellular protein lipoylation through direct binding to LIAS

Journal of Biological Chemistry, 2023
Abstract Ferredoxins are a family of iron-sulfur (Fe-S) cluster proteins that serve as essential electron donors in numerous cellular processes that are conserved through evolution. The promiscuous nature of ferredoxins as electron donors enables them to participate in many metabolic processes including steroid, heme, vitamin D and Fe-S
Margaret B. Dreishpoon, Nolan R. Bick, Boryana Petrova, Douglas M. Warui, Alison Cameron, Squire J. Booker, Naama Kanarek, Todd R. Golub, Peter Tsvetkov   +8 more
openaire   +3 more sources

Data_Sheet_2_Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma.CSV

, 2022
Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors.
Hanwen Lu (5434433), Bingchang Zhang (3431312), Huiyin Yang (14189297), Zhanxiang Wang (775482), Yuanyuan Xie (662418), Liwei Zhou (275029)   +5 more
core   +1 more source

DataSheet1_Pan-cancer analyses confirmed the cuproptosis-related gene FDX1 as an immunotherapy predictor and prognostic biomarker.ZIP

, 2022
Background: The latest research identified cuproptosis as an entirely new mechanism of cell death. However, as a key regulator in copper-induced cell death, the prognostic and immunotherapeutic value of FDX1 in pan-cancer remains unclear.Methods: Data ...
Chi Zhang (9857), Kaikai Wang (1404853), Jianhao Zhang (1728817), Xiuchen Guo (794314), Shengwei Huang (381112), Mengmeng Ji (6746750), Yuanxiao Zeng (13201842), Hangjing Shen (13201845)   +7 more
core   +1 more source

Data_Sheet_1_Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma.CSV

, 2022
Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors.
Hanwen Lu (5434433), Bingchang Zhang (3431312), Huiyin Yang (14189297), Zhanxiang Wang (775482), Yuanyuan Xie (662418), Liwei Zhou (275029)   +5 more
core   +1 more source

Tumor cuproptosis and immune infiltration improve survival of patients with hepatocellular carcinoma with a high expression of ferredoxin 1

Frontiers in Oncology, 2023
BackgroundCuproptosis is a novel cell death pathway dependent on cellular copper ions and ferredoxin 1 (FDX1). Hepatocellular carcinoma (HCC) is derived from healthy liver as a central organ for copper metabolism.
Yingyao Quan, Wei Li, Rongrong Yan, Jing Cheng, Heng Xu, Lin Chen   +5 more
doaj   +1 more source

The expression and migration of FDX1 in osteosarcoma.

, 2023
(A)The protein expression levels of FDX1 in hFOB1.19, U2OS, MG63, and 143B. The migration ability of U2OS cell in Vector-NC group and FDX1-OE group by transwell assay without Matrigel (B) and wound healing assay (C).
Feng Lu (173759), Guowen Wang (740833), Jin Zhang (53297), Jinwu Wang (460367), Yao Xu (247302), Xiuxin Han (740827), Jinyan Feng (13016481), Chao Zhang (51048)   +7 more
core   +1 more source

Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells

Journal of Biological Chemistry, 2023
Iron-sulfur clusters (ISC) are essential cofactors that participate in electron transfer, environmental sensing, and catalysis. Amongst the most ancient ISC-containing proteins are the ferredoxin (FDX) family of electron carriers. Humans have two FDXs- FDX1 and FDX2, both of which are localized to mitochondria, and the latter of which is itself ...
Pallavi R. Joshi, Shayan Sadre, Xiaoyan A. Guo, Jason G. McCoy, Vamsi K. Mootha   +4 more
openaire   +2 more sources

DataSheet_1_Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma.pdf

, 2022
BackgroundThe mechanism of copper-induced cellular death was newly discovered and termed cuproptosis. Inducing cuproptosis in cancer cells is well anticipated for its curative potential in treating tumor diseases.
Quan Cheng (1332420), Hui Cao (182176), Jiahao Xu (10145246), Zhengang Hu (10454609), Xiaoyan Wang (8433), Jingbo Li (124294), Hao Zhang (15339), Peng Luo (488595), Jian Zhang (1682)   +8 more
core   +1 more source