Results 61 to 70 of about 3,265 (192)

FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production

Redox Biology
Background: Mitochondrial dysfunction and metabolic reprogramming can lead to the development and progression of hepatocellular carcinoma (HCC). Ferredoxin 1 (FDX1) is a small mitochondrial protein and recent studies have shown that FDX1 plays an ...
Bo Sun, Peng Ding, Yinghui Song, Jia Zhou, Xu Chen, Chuang Peng, Sulai Liu   +6 more
doaj   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Table2_A novel prognostic signature of cuproptosis-related genes and the prognostic value of FDX1 in gliomas.XLSX

, 2022
Background: Gliomas are the most common malignant tumors of the central nervous system, with extremely bad prognoses. Cuproptosis is a novel form of regulated cell death. The impact of cuproptosis-related genes on glioma development has not been reported.
Hengyang Ouyang (13005819), Jiacong Tan (13005822), YeYu Zhao (14245331), HuaXin Zhu (14245322), Xinyi Pan (11735786), MeiHua Li (14245328), Qinsi Wan (14245325)   +6 more
core   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma

World Journal of Gastrointestinal Surgery
BACKGROUND Stomach adenocarcinoma (STAD) is one of the main reasons for cancer-related deaths worldwide. This investigation aimed to define the connection between STAD and Cuproptosis-related genes (CRGs). Cuproptosis is a newly identified form of mitochondrial cell death triggered by copper.
Xie, Xian-Ze, Zuo, Lei, Huang, Wei, Fan, Qiao-Mei, Weng, Ya-Yun, Yao, Wen-Dong, Jiang, Jia-Li, Jin, Jia-Qi   +7 more
openaire   +2 more sources

Table1_A novel prognostic signature of cuproptosis-related genes and the prognostic value of FDX1 in gliomas.XLSX

, 2022
Background: Gliomas are the most common malignant tumors of the central nervous system, with extremely bad prognoses. Cuproptosis is a novel form of regulated cell death. The impact of cuproptosis-related genes on glioma development has not been reported.
Hengyang Ouyang (13005819), Jiacong Tan (13005822), YeYu Zhao (14245331), HuaXin Zhu (14245322), Xinyi Pan (11735786), MeiHua Li (14245328), Qinsi Wan (14245325)   +6 more
core   +1 more source

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

DataSheet1_A novel prognostic signature of cuproptosis-related genes and the prognostic value of FDX1 in gliomas.DOCX

, 2022
Background: Gliomas are the most common malignant tumors of the central nervous system, with extremely bad prognoses. Cuproptosis is a novel form of regulated cell death. The impact of cuproptosis-related genes on glioma development has not been reported.
Hengyang Ouyang (13005819), Jiacong Tan (13005822), YeYu Zhao (14245331), HuaXin Zhu (14245322), Xinyi Pan (11735786), MeiHua Li (14245328), Qinsi Wan (14245325)   +6 more
core   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Table3_A novel prognostic signature of cuproptosis-related genes and the prognostic value of FDX1 in gliomas.XLSX

, 2022
Background: Gliomas are the most common malignant tumors of the central nervous system, with extremely bad prognoses. Cuproptosis is a novel form of regulated cell death. The impact of cuproptosis-related genes on glioma development has not been reported.
Hengyang Ouyang (13005819), Jiacong Tan (13005822), YeYu Zhao (14245331), HuaXin Zhu (14245322), Xinyi Pan (11735786), MeiHua Li (14245328), Qinsi Wan (14245325)   +6 more
core   +1 more source