Results 51 to 60 of about 3,265 (192)

Table1_Pan-cancer integrated bioinformatics analysis reveals cuproptosis related gene FDX1 is a potential prognostic and immunotherapeutic biomarker for lower-grade gliomas.DOCX

, 2023
FDX1 participates in cuproptosis, a copper-dependent cell death mode, which might influence tumor progressions like ferroptosis and pyroptosis. However, the role of FDX1 in tumors remains to be explored.
Chunyan Wang (306606), Shupeng Liu (322806), Wei Huang (36889), Yuliang Wu (153894), Zhongping Cheng (3925184), Jihui Zhu (8177748), Ning Luo (129120)   +6 more
core   +1 more source

Tanshinone IIA attenuates cognitive impairment in vascular dementia rats by modulating copper homeostasis via the SLC31A1/FDX1 axis. [PDF]

PLoS One
Background Tanshinone IIA (TSA) is the core liposoluble active component of Salvia miltiorrhiza , a traditional Chinese medicine, and exhibits ...
Lv H, Yang X, Liu Y, Zhou J, Yu W.
europepmc   +2 more sources

Chlamydomonas reinhardtii Chloroplasts Contain a Homodimeric Pyruvate:Ferredoxin Oxidoreductase That Functions with FDX1     [PDF]

Plant Physiology, 2012
Abstract Eukaryotic algae have long been known to live in anoxic environments, but interest in their anaerobic energy metabolism has only recently gained momentum, largely due to their utility in biofuel production. Chlamydomonas reinhardtii figures remarkably in this respect, because it efficiently produces hydrogen and its genome ...
van Lis, Robert, Baffert, C., Coute, Y., Nitschke, W., Atteia, A.   +4 more
openaire   +3 more sources

Table_1_Cuproptosis-related gene FDX1 expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma.xlsx

, 2022
BackgroundCuproptosis, a newly discovered form of cell death, is regulated by protein lipoylation and is related to mitochondrial metabolism. However, further research is needed to determine how the cuproptosis-related gene ferredoxin 1 (FDX1) affects ...
Bin Li (39349), Dawei Liu (156201), Tao Wang (12008), Qing Li (84975), Yufeng Liu (307498), Yang Luo (350920)   +5 more
core   +1 more source

The effect of cuproptosis-relevant genes on the immune infiltration and metabolism of gynecological oncology by multiply analysis and experiments validation

Scientific Reports, 2023
Gynecological cancers are a leading cause of mortality for women, including ovarian cancer (OC), cervical squamous cell carcinoma (CESC), and uterine corpus endometrial carcinoma (UCEC).
Xiao-min Ran, Hui Xiao, Yan-xiang Tang, Xia Jin, Xing Tang, Juan Zhang, Hui Li, Yu-kun Li, Zhen-zi Tang   +8 more
doaj   +1 more source

Elucidating Cuproptosis-Associated Genes in the Progression from Nash to HCC Using Bulk and Single-Cell RNA Sequencing Analyses and Experimental Validation

Medicina, 2023
Background and Objectives: Non-alcoholic steatohepatitis (NASH) is a significant risk factor for hepatocellular carcinoma (HCC) development. Timely treatment during the NASH stage is essential to minimize the possibility of disease progression to HCC ...
Zizuo Zhao, Tiankuo Luan, Jingyuan Wan, Hui Du, Jun Hu, Hao Liu, Xia Gong, Ge Kuang, Bin Wang   +8 more
doaj   +1 more source

Sanguinarine exerts anti-hepatocellular carcinoma activity by targeting FDX1 to induce FDX1/LIAS/DLAT/HSP70 axis-dependent cuproptosis

Acta Biochimica et Biophysica Sinica
Hepatocellular carcinoma (HCC), the predominant type of primary liver cancer, represents an extremely aggressive malignancy. The induction of cuproptosis has developed into a favorable therapeutic direction for HCC, considering its strong association with HCC.
Xiaoyan, Hao, Yiqiao, Qiu, Ling, Li, Siqi, Chen, Yuxuan, Gao, Ketao, Ma, Lili, Wei, Qiang, Zhang, Liang, Zhang   +8 more
openaire   +2 more sources

FDX1 serves as a prognostic biomarker and promotes glioma progression by regulating the immune response

Aging, 2023
The present study investigates the prognostic value of the FDX1 gene and its association with immune infiltration in gliomas. Gene expression profiles and corresponding clinical parameters of glioma patients were obtained from the Cancer Genome Atlas and Chinese Glioma Genome Atlas databases.
Zhang, Guangying, Shen, Liangfang, Li, Zhanzhan, Zhao, Yajie   +3 more
openaire   +2 more sources

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

DataSheet2_A novel prognostic signature of cuproptosis-related genes and the prognostic value of FDX1 in gliomas.CSV

, 2022
Background: Gliomas are the most common malignant tumors of the central nervous system, with extremely bad prognoses. Cuproptosis is a novel form of regulated cell death. The impact of cuproptosis-related genes on glioma development has not been reported.
Hengyang Ouyang (13005819), Jiacong Tan (13005822), YeYu Zhao (14245331), HuaXin Zhu (14245322), Xinyi Pan (11735786), MeiHua Li (14245328), Qinsi Wan (14245325)   +6 more
core   +1 more source