Results 31 to 40 of about 3,265 (192)

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis

Nature Communications
Cuproptosis is a recently described form of regulated cell death triggered by ionophore-induced copper (Cu) overload in mitochondria. It is critically dependent on ferredoxin 1 (FDX1), a mitochondrial iron-sulfur cluster containing protein that acts as ...
Jeffrey C. Hsiao, Douglas M. Warui, Jason J. Kwon, Margaret B. Dreishpoon, Nolan R. Bick, Tamra Blue-Lahom, David E. Root, Squire J. Booker, Peter Tsvetkov   +8 more
doaj   +3 more sources

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress [PDF]

, 2018
SUMMARY The mechanisms used by cancer cells to resist the severe disruption in protein homeostasis caused by proteasome inhibitors remain obscure. Here, we show this resistance correlates with a metabolic shift from glycolysis to oxidative phosphorylation (OXPHOS).
Tsvetkov, Peter, Detappe, Alexandre, Cai, Kai, Keys, Heather R., Brune, Zarina, Ying, Weiwen, Thiru, Prathapan, Reidy, Mairead, Kugener, Guillaume, Tsherniak, Aviad, Santagata, Sandro, Whitesell, Luke, Markley, John L., Ghobrial, Irene M., Lindquist, Susan   +14 more
openaire   +2 more sources

Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co‐factors in zebrafish [PDF]

Journal of Neuroendocrinology, 2018
The spatial and temporal expression of steroidogenic genes in zebrafish has not been fully characterised. Because zebrafish are increasingly employed in endocrine and stress research, a better characterisation of steroidogenic pathways is required to target specific steps in the biosynthetic pathways.
Weger, M., Diotel, N., Weger, B.D., Beil, T., Zaucker, A., Eachus, H.L., Oakes, J.A., do Rego, J.L., Storbeck, K.-H., Gut, P., Straehle, U., Rastegar, S., Mueller, F., Krone, N.   +13 more
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Emodin triggers cuproptosis to suppress hepatocellular carcinoma via SLC7A11/FDX1 axis [PDF]

Frontiers in Oncology
BackgroundHepatocellular carcinoma (HCC) is a lethal malignancy with limited therapeutic options, necessitating novel treatment strategies. This study investigates the potential of emodin, a natural anthraquinone, to suppress HCC by inducing cuproptosis,
Yantong Chen, Yantong Chen, Yantong Chen, Yanmei Liu, Yanmei Liu, Yanmei Liu, Jianwen Huang   +6 more
doaj   +2 more sources

ASPP2 inhibits hepatocellular carcinoma growth by regulating cuproptosis via mitochondrial protein lipoylation [PDF]

Cell Death and Disease
Hepatocellular carcinoma (HCC) is a metabolically active malignancy. Cuproptosis, a copper-dependent programmed cell death pathway, has been found to be closely associated with tumor progression.
Lu Yang, Xuhui Li, Yutong Jiang, Mingzhu Zhang, Tiantian Wu, Peixian Pi, Zhuozhuo Han, Zhiyu Zhang, Fangyuan Kong, Xiuhong Lu, Hao Yang, Chaohui Zuo, Gang Huang, Jian Zhao, Beibei Liang   +14 more
doaj   +2 more sources

AT-101 inhibits the proliferation and invasion of tongue squamous carcinoma cells by targeting the miR-21-5p/FDX1 axis [PDF]

Scientific Reports
Tongue squamous cell carcinoma (TSCC) is an aggressive oral malignancy with an increasing incidence worldwide, however, the molecular regulatory mechanisms underlying its progression still unclear.
Shuai Fu, Qing-ying Cui, Xiao-yu Tuo, Yong Wu, Ping Ji   +4 more
doaj   +2 more sources

Characterization of the functional effects of ferredoxin 1 as a cuproptosis biomarker in cancer

Frontiers in Genetics, 2022
Background: Cuproptosis is a recently discovered form of programmed cell death. Ferredoxin 1 (FDX1) is a key gene that mediates this process. However, the role of FDX1 in human tumors is not clear.Methods: We comprehensively analyzed the differential ...
Xiang Li, Zihan Dai, Jincheng Liu, Zhenqian Sun, Na Li, Guangjun Jiao, Hongxin Cao   +6 more
doaj   +1 more source

Pan-cancer integrated bioinformatics analysis reveals cuproptosis related gene FDX1 is a potential prognostic and immunotherapeutic biomarker for lower-grade gliomas

Frontiers in Molecular Biosciences, 2023
FDX1 participates in cuproptosis, a copper-dependent cell death mode, which might influence tumor progressions like ferroptosis and pyroptosis. However, the role of FDX1 in tumors remains to be explored.
Wei Huang, Yuliang Wu, Yuliang Wu, Jihui Zhu, Ning Luo, Chunyan Wang, Shupeng Liu, Zhongping Cheng   +7 more
doaj   +1 more source

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science
Cuproptosis, a recently defined copper‐dependent cell death pathway, remains largely unexplored in tumor therapies, particularly in breast cancer. This study demonstrates that triple‐negative breast cancer (TNBC) bears a relatively elevated copper levels
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
doaj   +3 more sources

The FDX1 methylation regulatory mechanism in the malignant phenotype of glioma

Genomics, 2023
To explore FDX1 methylation as a regulatory mechanism in the malignant phenotype of glioma, we screened for pathways involved through bioinformatic analysis, then proceeded with RIP and cell models to verify the regulation of RNAs and mitophagy. We chose Clone and Transwell assays to evaluate the malignant phenotype of glioma cells. MMP was detected by
Li, Guowei, Lu, Xiufang, Xu, Qianqian, Jin, Yanping   +3 more
openaire   +2 more sources