Results 31 to 40 of about 2,610 (155)

Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells

Journal of Biological Chemistry, 2023
Iron-sulfur clusters (ISC) are essential cofactors that participate in electron transfer, environmental sensing, and catalysis. Amongst the most ancient ISC-containing proteins are the ferredoxin (FDX) family of electron carriers. Humans have two FDXs- FDX1 and FDX2, both of which are localized to mitochondria, and the latter of which is itself ...
Pallavi R. Joshi, Shayan Sadre, Xiaoyan A. Guo, Jason G. McCoy, Vamsi K. Mootha   +4 more
openaire   +2 more sources

Tumor cuproptosis and immune infiltration improve survival of patients with hepatocellular carcinoma with a high expression of ferredoxin 1

Frontiers in Oncology, 2023
BackgroundCuproptosis is a novel cell death pathway dependent on cellular copper ions and ferredoxin 1 (FDX1). Hepatocellular carcinoma (HCC) is derived from healthy liver as a central organ for copper metabolism.
Yingyao Quan, Wei Li, Rongrong Yan, Jing Cheng, Heng Xu, Lin Chen   +5 more
doaj   +1 more source

FDX1 regulates cellular protein lipoylation through direct binding to LIAS

Journal of Biological Chemistry, 2023
Abstract Ferredoxins are a family of iron-sulfur (Fe-S) cluster proteins that serve as essential electron donors in numerous cellular processes that are conserved through evolution. The promiscuous nature of ferredoxins as electron donors enables them to participate in many metabolic processes including steroid, heme, vitamin D and Fe-S
Margaret B. Dreishpoon, Nolan R. Bick, Boryana Petrova, Douglas M. Warui, Alison Cameron, Squire J. Booker, Naama Kanarek, Todd R. Golub, Peter Tsvetkov   +8 more
openaire   +3 more sources

Cuproptosis-related gene FDX1 as a prognostic biomarker for kidney renal clear cell carcinoma correlates with immune checkpoints and immune cell infiltration

Frontiers in Genetics, 2023
Background: Kidney renal clear cell carcinoma (KIRC) is not sensitive to radiotherapy and chemotherapy, and only some KIRC patients can benefit from immunotherapy and targeted therapy.
Yimin Yao, Haixin Chen, Minjun Lou, Tingting Chen   +3 more
doaj   +1 more source

Cuproptosis-Related MiR-21-5p/FDX1 Axis in Clear Cell Renal Cell Carcinoma and Its Potential Impact on Tumor Microenvironment

Cells, 2022
As a newly identified type of programmed cell death, cuproptosis may have an impact on cancer development, including clear cell renal cell carcinoma (ccRCC).
Mingyue Xie, Bo Cheng, Shuang Yu, Yajie He, Yu Cao, Tiejun Zhou, Kun Han, Rongyang Dai, Ronghao Wang   +8 more
doaj   +1 more source

Chlamydomonas reinhardtii Chloroplasts Contain a Homodimeric Pyruvate:Ferredoxin Oxidoreductase That Functions with FDX1     [PDF]

Plant Physiology, 2012
Abstract Eukaryotic algae have long been known to live in anoxic environments, but interest in their anaerobic energy metabolism has only recently gained momentum, largely due to their utility in biofuel production. Chlamydomonas reinhardtii figures remarkably in this respect, because it efficiently produces hydrogen and its genome ...
van Lis, Robert, Baffert, C., Coute, Y., Nitschke, W., Atteia, A.   +4 more
openaire   +3 more sources

Role of Ferredoxin 1 <i>(FDX1)</i> in cancer and its therapeutic potential. [PDF]

Cancer Pathog Ther
He F, Zhao H, Gao R, Lu M, Wang S, Chen Y, Peng L, Xia J.   +7 more
europepmc   +2 more sources

Elucidating Cuproptosis-Associated Genes in the Progression from Nash to HCC Using Bulk and Single-Cell RNA Sequencing Analyses and Experimental Validation

Medicina, 2023
Background and Objectives: Non-alcoholic steatohepatitis (NASH) is a significant risk factor for hepatocellular carcinoma (HCC) development. Timely treatment during the NASH stage is essential to minimize the possibility of disease progression to HCC ...
Zizuo Zhao, Tiankuo Luan, Jingyuan Wan, Hui Du, Jun Hu, Hao Liu, Xia Gong, Ge Kuang, Bin Wang   +8 more
doaj   +1 more source

The effect of cuproptosis-relevant genes on the immune infiltration and metabolism of gynecological oncology by multiply analysis and experiments validation

Scientific Reports, 2023
Gynecological cancers are a leading cause of mortality for women, including ovarian cancer (OC), cervical squamous cell carcinoma (CESC), and uterine corpus endometrial carcinoma (UCEC).
Xiao-min Ran, Hui Xiao, Yan-xiang Tang, Xia Jin, Xing Tang, Juan Zhang, Hui Li, Yu-kun Li, Zhen-zi Tang   +8 more
doaj   +1 more source

FDX1 serves as a prognostic biomarker and promotes glioma progression by regulating the immune response

Aging, 2023
The present study investigates the prognostic value of the FDX1 gene and its association with immune infiltration in gliomas. Gene expression profiles and corresponding clinical parameters of glioma patients were obtained from the Cancer Genome Atlas and Chinese Glioma Genome Atlas databases.
Zhang, Guangying, Shen, Liangfang, Li, Zhanzhan, Zhao, Yajie   +3 more
openaire   +2 more sources