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Pan-cancer analysis of whole genomes. [PDF]
Nature, 2020 Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3.
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (8472573)
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Pan‐cancer analysis shapes the understanding of cancer biology and medicine
Cancer CommunicationsAdvances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are ...
Xiaoping Cen +21 more
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Biomedicines, 2021 Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA (miRNA) expression and aberrant ...
Rahaba Marima +9 more
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Frontiers in Oncology, 2021 A growing body of evidence has shown that circular RNA (circRNA) is a promising exosomal cancer biomarker candidate. However, global circRNA alterations in cancer and the underlying mechanism, essential for identification of ideal circRNA cancer ...
Xuezhu Wang +8 more
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Journal of Investigative Surgery, 2022 Objective To investigate the impact of serum albumin (at diagnosis and pre-operatively) on survival in patients undergoing cytoreductive surgery for advanced ovarian cancer(AOC) and whether improvement in albumin achieved following neoadjuvant ...
Dairui Dai +6 more
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Frontiers in Medicine, 2021 Although all cancers are molecularly distinct, many share common driver mutations. Pan-cancer analysis, utilizes next-generation sequencing (NGS), pan-cancer model systems, and pan-cancer projects such as The Cancer Genome Atlas (TCGA), to assess ...
Xianwen Zhang +9 more
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Viral Encoded miRNAs in Tumorigenesis: Theranostic Opportunities in Precision Oncology
Microorganisms, 2022 About 15% of all human cancers have a viral etiology. Although progress has been made, understanding the viral oncogenesis and associated molecular mechanisms remain complex. The discovery of cellular miRNAs has led to major breakthroughs. Interestingly,
Rodney Hull +6 more
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Microorganisms, 2022 Cervical cancer (CC) is the primary cause of female cancer fatalities in low-middle-income countries (LMICs). Persistent infections from the human papillomavirus (HPV) can result in cervical cancer.
Afra Basera +6 more
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Cancer Medicine, 2023 Background In the Community of Latin American and Caribbean States (CELAC), breast cancer and cervical cancer are the first and third causes of cancer death among females. The objectives are to assess the characteristics of the cervical and breast cancer
Isabel Mosquera +8 more
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From Incidence to Intervention: A Comprehensive Look at Breast Cancer in South Africa
Oncology and Therapy, 2023 The formidable impact of breast cancer extends globally, with South Africa facing pronounced challenges, including significant disparities in breast cancer screening, treatment and survival along ethnic and socioeconomic lines. Over the last two decades,
Zodwa Dlamini +10 more
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