Results 1 to 10 of about 240,506 (198)

Identification of lncRNAs Indicating Immune Pathway Activity for Predicting Prognosis and Immunotherapy Response in Pan-Cancer. [PDF]

Cancer Med
Background The critical role of long non‐coding RNAs (lncRNAs) in tumor immunity has garnered increasing attention, and immune pathways are key regulatory factors in tumor immune mechanisms.
Xin M, He D, Dai Y, Liu Q, Sun R, Li H, Zhang Y, Li J, Ning S, Guo Q, Gao Y, Wang P.   +11 more
europepmc   +2 more sources

MicroRNA and Alternative mRNA Splicing Events in Cancer Drug Response/Resistance: Potent Therapeutic Targets

Biomedicines, 2021
Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA (miRNA) expression and aberrant ...
Rahaba Marima, Flavia Zita Francies, Rodney Hull, Thulo Molefi, Meryl Oyomno, Richard Khanyile, Sikhumbuzo Mbatha, Mzubanzi Mabongo, David Owen Bates, Zodwa Dlamini   +9 more
doaj   +1 more source

Machine Learning-Based Comparative Analysis of Pan-Cancer and Pan-Normal Tissues Identifies Pan-Cancer Tissue-Enriched circRNAs Related to Cancer Mutations as Potential Exosomal Biomarkers

Frontiers in Oncology, 2021
A growing body of evidence has shown that circular RNA (circRNA) is a promising exosomal cancer biomarker candidate. However, global circRNA alterations in cancer and the underlying mechanism, essential for identification of ideal circRNA cancer ...
Xuezhu Wang, Xuezhu Wang, Yucheng Dong, Yucheng Dong, Zilong Wu, Guanqun Wang, Yue Shi, Yue Shi, Yongchang Zheng   +8 more
doaj   +1 more source

Serum Albumin as a Predictor of Survival after Interval Debulking Surgery for Advanced Ovarian Cancer (AOC): A Retrospective Study

Journal of Investigative Surgery, 2022
Objective To investigate the impact of serum albumin (at diagnosis and pre-operatively) on survival in patients undergoing cytoreductive surgery for advanced ovarian cancer(AOC) and whether improvement in albumin achieved following neoadjuvant ...
Dairui Dai, Janos Balega, Sudha Sundar, Sean Kehoe, Ahmed Elattar, Andrew Phillips, Kavita Singh   +6 more
doaj   +1 more source

Visualization and Analysis in the Field of Pan-Cancer Studies and Its Application in Breast Cancer Treatment

Frontiers in Medicine, 2021
Although all cancers are molecularly distinct, many share common driver mutations. Pan-cancer analysis, utilizes next-generation sequencing (NGS), pan-cancer model systems, and pan-cancer projects such as The Cancer Genome Atlas (TCGA), to assess ...
Xianwen Zhang, Han Lai, Fan Zhang, Yixi Wang, Li Zhang, Ni Yang, Chunrong Wang, Zheng Liang, Jieping Zeng, Jinrong Yang   +9 more
doaj   +1 more source

Viral Encoded miRNAs in Tumorigenesis: Theranostic Opportunities in Precision Oncology

Microorganisms, 2022
About 15% of all human cancers have a viral etiology. Although progress has been made, understanding the viral oncogenesis and associated molecular mechanisms remain complex. The discovery of cellular miRNAs has led to major breakthroughs. Interestingly,
Rodney Hull, Rahaba Marima, Mohammed Alaouna, Demetra Demetriou, Rui Manuel Reis, Thulo Molefi, Zodwa Dlamini   +6 more
doaj   +1 more source

Competing Endogenous RNA (ceRNA) Networks and Splicing Switches in Cervical Cancer: HPV Oncogenesis, Clinical Significance and Therapeutic Opportunities

Microorganisms, 2022
Cervical cancer (CC) is the primary cause of female cancer fatalities in low-middle-income countries (LMICs). Persistent infections from the human papillomavirus (HPV) can result in cervical cancer.
Afra Basera, Rodney Hull, Demetra Demetriou, David Owen Bates, Andreas Martin Kaufmann, Zodwa Dlamini, Rahaba Marima   +6 more
doaj   +1 more source

Assessment of organization of cervical and breast cancer screening programmes in the Latin American and the Caribbean states: The CanScreen5 framework

Cancer Medicine, 2023
Background In the Community of Latin American and Caribbean States (CELAC), breast cancer and cervical cancer are the first and third causes of cancer death among females. The objectives are to assess the characteristics of the cervical and breast cancer
Isabel Mosquera, Clara B. Barajas, Li Zhang, Eric Lucas, Sara Benitez Majano, Mauricio Maza, Silvana Luciani, Partha Basu, Andre L. Carvalho   +8 more
doaj   +1 more source

From Incidence to Intervention: A Comprehensive Look at Breast Cancer in South Africa

Oncology and Therapy, 2023
The formidable impact of breast cancer extends globally, with South Africa facing pronounced challenges, including significant disparities in breast cancer screening, treatment and survival along ethnic and socioeconomic lines. Over the last two decades,
Zodwa Dlamini, Thulo Molefi, Richard Khanyile, Mahlori Mkhabele, Botle Damane, Alexandre Kokoua, Meshack Bida, Kamal S. Saini, Nkhensani Chauke-Malinga, Thifhelimbilu Emmanuel Luvhengo, Rodney Hull   +10 more
doaj   +1 more source

Landscape of IDH1/2 mutations in Chinese patients with solid tumors: A pan‐cancer analysis

Molecular Genetics & Genomic Medicine, 2021
Background Isocitrate dehydrogenase (IDH) is an enzyme family involved in cell aerobic metabolism of tricarboxylic acid cycle. However, the landscape of IDH mutations in pan‐cancer has not been fully characterized.
Dong Shen, Junling Zhang, Kai Yuan, Jing Zhao, Zhengyi Zhao, Longgang Cui, Yuzi Zhang, Guoqiang Wang, Shangli Cai, Yuezong Bai, Wei Li, Xiang Huang   +11 more
doaj   +1 more source