Results 31 to 40 of about 242,136 (99)

Accelerating the elimination of cervical cancer: cross-sectional examination of cancer prevention and control in Latin America and the CaribbeanResearch in context

The Lancet Regional Health. Americas
Summary: Background: Cervical cancer is a public health problem in Latin America and the Caribbean (LAC). The Cervical Cancer Elimination strategy sets three targets (90% HPV vaccination, 70% screening, 90% treatment) for countries to be in the path ...
Sara Benitez Majano, Nathalia Katz, Soledad Urrutia, Roberta Caixeta, Carlos Torres, Carolina Chavez Cortes, Maribel Almonte, Melissa Lopez Varon, Reina Guerrero, Kathleen Schmeler, Erin Kobetz, Corinne Ferrari, Carlos Espinal, Francisco Becerra-Posada, Karla Alfaro, Daniel Salas, Anselm Hennis, Silvana Luciani, Mauricio Maza   +18 more
doaj   +1 more source

Leveraging Quantitative Proteomics and Extracellular Vesicle Data to Uncover Druggable Receptor Kinases Across Cancers

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) play an important role in cancer progression and metastasis. The increasing clinical proteomics data provides an opportunity to uncover new biomarkers and therapeutic targets in cancer specific EVs.
Jina Kim, Su Yeon Yeon, Kyerim Choi, Hojung Kim, Hyoyoung Kim, Daehee Hwang, Sungyong You   +6 more
doaj   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science
Drug resistance remains a major obstacle in cancer therapy, and direct mechanical disruption of cellular structures offers a promising strategy for overcoming it, highlighting the urgent clinical need for an effective and universal pan‐cancer treatment ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
doaj   +1 more source

Functional cytokine-based classification of tumor-infiltrating lymphocytes in melanoma

Scientific Reports
Tumor-infiltrating lymphocytes (TILs) are important prognostic and predictive biomarkers of melanoma. However, the histological classification of TILs into brisk, non-brisk, or absent categories remains subjective and prone to inter-observer variability.
Meshack Bida, Rodney Hull, Thabiso Victor Miya, Tebogo Marutha, Zodwa Dlamini   +4 more
doaj   +1 more source

Pan‐cancer analyses of immunogenic cell death‐derived gene signatures: Potential biomarkers for prognosis and immunotherapy

Cancer Reports
Background Immunogenic cell death (ICD) is a type of regulated cell death that is capable of initiating an adaptive immune response. Induction of ICD may be a potential treatment strategy, as it has been demonstrated to activate the tumor‐specific immune
Xiaodan Han, Di Song, Yongliang Cui, Yonggang Shi, Xiaobin Gu   +4 more
doaj   +1 more source

Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs

Advanced Science
Many cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)‐mediated genetic effects from 28 033 RNA sequencing samples across 11 ...
Wenyan Chen, Zeyang Wang, Yinuo Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yangmei Qin, Kewei Xiong, Xixian Ma, Qi Liao, Yunbo Qiao, Lei Li   +14 more
doaj   +1 more source

A Prognostic Model Based on Nutritional Indexes for Patients With Pan‐Cancer: A Real‐World Cohort Study

Cancer Reports
Background The aim was to identify the nutritional indexes, construct a prognostic model, and develop a nomogram for predicting individual survival probability in pan‐cancers.
Lin Zheng, Qian‐Qian Yu, Wen‐Bin Ruan, Jin Chen, Qing‐Hua Deng, Ke Zhang, Xu‐Li Jiang, Wen‐Jun Jiang, Dan‐Na Cai, Chen‐Jie He, Yu‐Feng Wang, Shen‐Li Jiang, Rui‐Zhi Ye, Guang‐Xian You, Rong‐Biao Ying, Zhi‐Rui Zhou   +15 more
doaj   +1 more source

Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma

Clinical and Translational Medicine
Background DDB1 and CUL4‐associated factor 7 (DCAF7) is a WD‐repeat adaptor that recruits substrates to the CUL4DDB1 ubiquitinligase complex, but its pan‐cancer relevance and mechanistic contribution to tumor progression remain unclear.
Ruina Luan, Hanbin Lin, Xin Zhao, Jianpeng Li, Maohe Chen, Shiping Luo, Xinjian Lin   +6 more
doaj   +1 more source

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan‐Cancer

Advanced Science
Understanding the prognosis of cancer patients is crucial for enabling precise diagnosis and treatment by clinical practitioners. Multimodal fusion models based on artificial intelligence (AI) offer a comprehensive depiction of the tumor heterogeneity ...
Feng Gao, Junxiang Ding, Baowen Gai, Du Cai, Chuling Hu, Feng‐Ao Wang, Ruikun He, Junwei Liu, Yixue Li, Xiao‐Jian Wu   +9 more
doaj   +1 more source

Plasmonic Heterojunction Nanomaterials for Noninvasive Pan‐Cancer Metabolomic Screening

Interdisciplinary Materials
Cancer remains a major global health challenge, underscoring the urgent need for early diagnostic strategies. Altered cancer metabolism can be captured through serum analysis by laser desorption/ionization mass spectrometry (LDI‐MS).
Jia Qi, Hairu Lin, Caiyun Fang, Jia Li, Fangying Shi, Chunhui Deng   +5 more
doaj   +1 more source