Results 21 to 30 of about 242,136 (99)

The molecular classification of cancer‐associated fibroblasts on a pan‐cancer single‐cell transcriptional atlas

Clinical and Translational Medicine, 2023
Background Cancer‐associated fibroblasts (CAFs), integral to the tumour microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic or anti‐tumourigenic functions.
Bonan Chen, Wai Nok Chan, Fuda Xie, Chun Wai Mui, Xiaoli Liu, Alvin H. K. Cheung, Raymond W. M. Lung, Chit Chow, Zhenhua Zhang, Canbin Fang, Peiyao Yu, Shihua Shi, Shikun Zhou, Guoming Chen, Zhangding Wang, Shouyu Wang, Xiaofan Ding, Bing Huang, Li Liang, Yujuan Dong, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Nathalie Wong, Jun Yu, Kwok Wai Lo, Gary M. K. Tse, Wei Kang, Ka Fai To   +28 more
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Pan‐cancer analyses reveal multi‐omic signatures and clinical implementations of the forkhead‐box gene family

Cancer Medicine, 2023
Background Forkhead box (FOX) proteins belong to one of the largest transcription factor families and play crucial roles in the initiation and progression of cancer.
Xiaoman Bi, Dehua Zheng, Jiale Cai, Dahua Xu, Liyang Chen, Zhizhou Xu, Meng Cao, Peihu Li, Yutong Shen, Hong Wang, Wuping Zheng, Deng Wu, Shaojiang Zheng, Kongning Li   +13 more
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Prognostic significance of the rho GTPase RHOV and its role in tumor immune cell infiltration: a comprehensive pan‐cancer analysis

FEBS Open Bio, 2023
Ras homolog gene family member V (RHOV) is an atypical Rho GTPase that participates in various important cellular processes. Although RHOV has been identified to play an oncogenic role in lung cancer and triple‐negative breast cancer, its role in other ...
Qin Qin, Bing Peng
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AARS2 as a novel biomarker for prognosis and its molecular characterization in pan‐cancer

Cancer Medicine, 2023
Introduction The mitochondrial alanyl‐tRNA synthetase 2 (AARS2) as one of aminoacyl‐tRNA synthases (ARSs) performs amino acid transportation and involves protein synthesis. However, its role in cancer remains largely unexplored.
Long Liu, Jie Gao, Xudong Liu, Feng Zhang, Bowen Hu, Huapeng Zhang, Zhihui Wang, Hongwei Tang, Ji Hua Shi, Shuijun Zhang   +9 more
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Exploiting the Molecular Basis of Oesophageal Cancer for Targeted Therapies and Biomarkers for Drug Response: Guiding Clinical Decision-Making

Biomedicines, 2022
Worldwide, oesophageal cancer is the sixth leading cause of deaths related to cancer and represents a major health concern. Sub-Saharan Africa is one of the regions of the world with the highest incidence and mortality rates for oesophageal cancer and ...
Sikhumbuzo Mbatha, Rodney Hull, Zodwa Dlamini   +2 more
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TCGAplot: an R package for integrative pan-cancer analysis and visualization of TCGA multi-omics data

BMC Bioinformatics, 2023
Background Pan-cancer analysis examines both the commonalities and heterogeneity among genomic and cellular alterations across numerous types of tumors.
Chenqi Liao, Xiong Wang
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YRDC is a Prognostic‐Related Biomarker Correlated With Immune Infiltration and Drug Sensitivity in Pan‐Cancer

Cancer Reports
Background YRDC has emerged as a potential biomarker in cancer, yet its prognostic value, oncogenic mechanisms, role in immune infiltration, and anticancer drugs efficacy in pan‐cancer remained poorly understood.
Li Qiao, Yuetong Zhang, Pin Huang
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Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications
Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are ...
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
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Pan‐Cancer Single‐Nucleus Total RNA Sequencing Using snHH‐Seq

Advanced Science
Tumor heterogeneity and its drivers impair tumor progression and cancer therapy. Single‐cell RNA sequencing is used to investigate the heterogeneity of tumor ecosystems. However, most methods of scRNA‐seq amplify the termini of polyadenylated transcripts,
Haide Chen, Xiunan Fang, Jikai Shao, Qi Zhang, Liwei Xu, Jiaye Chen, Yuqing Mei, Mengmeng Jiang, Yuting Wang, Zhouyang Li, Zihang Chen, Yang Chen, Chengxuan Yu, Lifeng Ma, Peijing Zhang, Tianyu Zhang, Yuan Liao, Yuexiao Lv, Xueyi Wang, Lei Yang, Yuting Fu, Daobao Chen, Liming Jiang, Feng Yan, Wei Lu, Gao Chen, Huahao Shen, Jingjing Wang, Changchun Wang, Tingbo Liang, Xiaoping Han, Yongcheng Wang, Guoji Guo   +32 more
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GTSE1: A potential prognostic and diagnostic biomarker in various tumors including lung adenocarcinoma

The Clinical Respiratory Journal
Objective This research was aimed to comprehensively investigate the expression levels, diagnostic and prognostic implications, and the relationship with immune infiltration of G2 and S phase‐expressed‐1 (GTSE1) across 33 tumor types, including lung ...
Guanqiang Yan, Guosheng Li, Xiang Gao, Jun Liu, Yue Li, Jingxiao Li, Huafu Zhou   +6 more
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