Results 21 to 30 of about 3,191,959 (309)
A pan-cancer organoid platform for precision medicine [PDF]
Cell Reports, 2021 Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer biology and develop novel precision medicine therapeutics. However, utilizing TOs for systems-biology-based approaches has been limited by a lack of scalable and reproducible methods to develop and profile these models. We describe a robust pan-cancer TO platform
Larsen, Brian M. +37 more
openaire +3 more sources
Plants, 2023 Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway activation, which leads to cell ...
Mohammed Alaouna +8 more
doaj +1 more source
Microorganisms, 2021 The influence of the naturally occurring population of microbes on various human diseases has been a topic of much recent interest. Not surprisingly, continuously growing attention is devoted to the existence of a gut brain axis, where the microbiota ...
Rodney Hull +11 more
doaj +1 more source
The pan-cancer pathological regulatory landscape [PDF]
Scientific Reports, 2016 AbstractDysregulation of the normal gene expression program is the cause of a broad range of diseases, including cancer. Detecting the specific perturbed regulators that have an effect on the generation and the development of the disease is crucial for understanding the disease mechanism and for taking decisions on efficient preventive and curative ...
Falco, Matias M. +3 more
openaire +4 more sources
Integrative Analysis the characterization of peroxiredoxins in pan-cancer [PDF]
Cancer Cell International, 2020 Abstract Peroxiredoxins (PRDXs) are antioxidant enzymes protein family members that involves the process of several biological functions, such as differentiation, cell growth. Considerable evidence demonstrates that PRDXs play critical roles in the occurrence and development of carcinomas.
Lei Gao +10 more
openaire +4 more sources
Pan-cancer patterns of DNA methylation [PDF]
Genome Medicine, 2014 AbstractThe comparison of DNA methylation patterns across cancer types (pan-cancer methylome analyses) has revealed distinct subgroups of tumors that share similar methylation patterns. Integration of these data with the wealth of information derived from cancer genome profiling studies performed by large international consortia has provided novel ...
Witte, Tania +2 more
openaire +2 more sources
Biomedicines, 2022 Worldwide, oesophageal cancer is the sixth leading cause of deaths related to cancer and represents a major health concern. Sub-Saharan Africa is one of the regions of the world with the highest incidence and mortality rates for oesophageal cancer and ...
Sikhumbuzo Mbatha +2 more
doaj +1 more source
Author Correction: Pan-cancer analysis of whole genomes.
, 2023 In the published version of this paper, the list of members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium and their affiliations contained minor errors in the affiliations. The original Article has been corrected to include the corrected
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium +1 more
core +1 more source
HER3 Is an Actionable Target in Advanced Prostate Cancer.
, 2021 It has been recognized for decades that ERBB signaling is important in prostate cancer, but targeting ERBB receptors as a therapeutic strategy for prostate cancer has been ineffective clinically.
Bertan, C +44 more
core +1 more source
En bloc resection of the external iliac vein along with broad ligament leiomyosarcoma: A case report
Case Reports in Women's Health, 2019 Outcomes following the excision of the external iliac vein during gynaecological oncology surgery are poorly documented. This is because most gynaecological oncologists consider tumours with vascular involvement inoperable.
Fatima Ahmed +5 more
doaj +1 more source