The study on cuproptosis in Alzheimer’s disease based on the cuproptosis key gene FDX1
Frontiers in Aging NeuroscienceBackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory and cognitive impairments. Previous studies have shown neuronal death in the brains of AD patients, but the role of cuproptosis and its associated genes in AD ...
Xiaozhen Gu, Qiqiang Tang
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Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis
Scientific Reports, 2023 Previous research has demonstrated that ferredoxin 1 (FDX1) contributes to the accumulation of toxic lipoylated dihydrolipoamide S-acetyltransferase (DLAT) and results in cuproptotic cell death. However, the role that FDX1 plays in human cancer prognosis
Ziqiang Liu, Jinfeng Miao
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Prognostic and immunological role of cuproptosis-related protein FDX1 in pan-cancer
Frontiers in Genetics, 2022 Background: Cancer is the second cause of death worldwide. Copperoptosis is a new mode of regulated cell death and is strongly associated with metabolic pathways.
Chen Xiao +6 more
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Frontiers in Medicine, 2022 Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors.
Hanwen Lu +12 more
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FDX1 can Impact the Prognosis and Mediate the Metabolism of Lung Adenocarcinoma [PDF]
Frontiers in Pharmacology, 2021 Background: Lung cancer has emerged as one of the most common cancers in recent years. The mitochondrial electron transport chain (ETC) is closely connected with metabolic pathways and inflammatory response. However, the influence of ETC-associated genes
Zeyu Zhang +6 more
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The role of FDX1 in granulosa cell of Polycystic ovary syndrome (PCOS) [PDF]
BMC Endocrine Disorders, 2021 Background To explore the development mechanism of PCOS and Transcriptomics was applied to seek the key gene. Methods Transcriptomics marked by UID (unique identifier) technique of granulosa cell in PCOS and control women was carried out and key gene was
Zhi Wang +5 more
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Atractylenolide III mitigates polycystic ovary syndrome by activating FDX1-mediated proliferation of ovarian granulocyte cells via PI3K/AKT/mTOR [PDF]
Journal of Ovarian ResearchBackground Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder among women of reproductive age worldwide. This study aimed to investigate the therapeutic potential and molecular mechanisms of Atractylenolide III (ATL-III),
Nan Zhou +10 more
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Modulating ovarian cancer progression through FDX1-driven autophagy
npj Precision OncologyFerredoxin 1 (FDX1) emerges as a crucial regulator of autophagy and copper metabolism in ovarian cancer (OC), as revealed by this investigation. Predominantly localized to the cytoplasm and mitochondria, FDX1 coordinates autophagic activity by modulating
Chang Liu +4 more
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METTL3-mediated m6A modification of FDX1 confers resistance to cuproptosis and promotes hepatocellular carcinoma progression [PDF]
Communications BiologyCuproptosis, a copper-dependent cell death pathway, is emerging as a potential cancer treatment strategy. N6-methyladenosine (m6A), the predominant eukaryotic RNA modification, regulates various cell death mechanisms; however, its role in cuproptosis ...
Qian Jiang +9 more
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Comprehensive analyses of biological function and tumor microenvironment with cuproptosis regulators and construction of a cuproptosis-related scoring system in thyroid cancer based on bioinformatics and experimental validation [PDF]
Frontiers in GeneticsBackgroundThe role of copper-induced cell death, termed cuproptosis, has been demonstrated recently. Nonetheless, the potential biological function of cuproptosis regulators in thyroid cancer (THCA) remains unknown.MethodWe analyzed the expression levels
Shitong Su +5 more
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