Results 11 to 20 of about 3,265 (192)
LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer
Redox BiologyBackground: Cuproptosis, a copper-dependent form of regulated cell death, has emerged as a redox-sensitive vulnerability in cancer. However, the molecular basis by which this process is initiated and sustained in tumors remains poorly defined.
Lingling Zhang, Zhuoran Sun
exaly +6 more sources
The study on cuproptosis in Alzheimer’s disease based on the cuproptosis key gene FDX1 [PDF]
Frontiers in Aging NeuroscienceBackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory and cognitive impairments. Previous studies have shown neuronal death in the brains of AD patients, but the role of cuproptosis and its associated genes in AD ...
Huili Wang, Xiaozhen Gu, Qiqiang Tang
exaly +6 more sources
Pan-cancer analysis of the upstream regulator FDX1 in cuproptosis [PDF]
Discover OncologyThe global incidence and mortality of cancer continue to rise rapidly, and cancer remains one of the most severe challenges in the field of public health.
Yan Xue +4 more
doaj +3 more sources
Cells, 2023 Background: Progress in the diagnosis and treatment of clear cell renal cell carcinoma (ccRCC) has significantly prolonged patient survival. However, ccRCC displays an extreme heterogenous characteristic and metastatic tendency, which limit the benefit ...
Le Qu, Aimin Jiang, Juan Lu
exaly +4 more sources
Frontiers in Genetics, 2022 Background: Gliomas are the most common malignant tumors of the central nervous system, with extremely bad prognoses. Cuproptosis is a novel form of regulated cell death. The impact of cuproptosis-related genes on glioma development has not been reported.
Li Meihua, Yeyu Zhao, Xinyi Pan
exaly +5 more sources
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2
Nature Chemical Biology, 2022 Ferredoxins comprise a large family of iron-sulfur (Fe-S) proteins that shuttle electrons in diverse biological processes. Human mitochondria contain two isoforms of [2Fe-2S] ferredoxins, FDX1 (aka adrenodoxin) and FDX2, with known functions in cytochrome P450-dependent steroid transformations and Fe-S protein biogenesis.
Vinzent Schulz +11 more
openaire +4 more sources
The Role of FDX1 in Granulosa Cell of Polycystic Ovary Syndrome (PCOS) [PDF]
BMC Endocrine Disorders, 2021 Abstract Background: To explore the development mechanism of PCOS and Transcriptomics was applied to seek the key gene.Methods: Transcriptomics marked by UID (unique identifier) technique of granulosa cell in PCOS and control women was measured. RT-PCR was applied to verify the key gene.
Zhi Wang +5 more
openaire +5 more sources
Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis
Scientific Reports, 2023 Previous research has demonstrated that ferredoxin 1 (FDX1) contributes to the accumulation of toxic lipoylated dihydrolipoamide S-acetyltransferase (DLAT) and results in cuproptotic cell death. However, the role that FDX1 plays in human cancer prognosis
Ziqiang Liu, Jinfeng Miao
doaj +3 more sources
Prognostic and immunological role of cuproptosis-related protein FDX1 in pan-cancer
Frontiers in Genetics, 2022 Background: Cancer is the second cause of death worldwide. Copperoptosis is a new mode of regulated cell death and is strongly associated with metabolic pathways.
Chen Xiao +6 more
doaj +3 more sources
Frontiers in Medicine, 2022 Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors.
Hanwen Lu +12 more
doaj +3 more sources