Results 51 to 60 of about 3,607 (128)

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, Volume 59, Issue 3, March 2026.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

Using Lipoamidase as a Novel Probe To Interrogate the Importance of Lipoylation in Plasmodium falciparum

mBio, 2018
Lipoate is a redox active cofactor that is covalently bound to key enzymes of oxidative metabolism. Plasmodium falciparum is auxotrophic for lipoate during the intraerythrocytic stages, but it is not known whether lipoate attachment to protein is ...
Hugo Jhun, Maroya S. Walters, Sean T. Prigge   +2 more
doaj   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred

Protein Science, Volume 35, Issue 2, February 2026.
Abstract FAALs (fatty acyl‐AMP ligases) recruit and incorporate fatty acids during the biosynthesis of secondary metabolites. Their diversity, distribution, and substrate specificity remain poorly understood, which limits functional predictions from sequence data.
Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão   +2 more
wiley   +1 more source

Boosting Cuproptosis in Breast Cancer Therapy via Photodynamic Treatment With a New Liposome

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
ABSTRACT Breast cancer (BC) is one of the most common cancers in women around the world, and utilizing a combined approach is a crucial strategy. Induction of cuproptosis in tumor cells is a novel antitumor approach, though its standalone efficacy remains unclear.
Jie Yu, Ning Sun, Limei You, Jialing Liu, Mengna Niu, Jiacheng Shi, Weixin Chen, Futong Li, Shengbao Wang, Jiaqi Liu   +9 more
wiley   +1 more source

Cuproptosis and prostate cancer: from molecular mechanisms and microenvironment remodeling to precision therapy

Frontiers in Oncology
Prostate cancer (PCa) is a leading malignancy, and progression to castration-resistant prostate cancer (CRPC) remains a central therapeutic challenge.
Zhonghao Tang, Zhonghao Tang, Si Shen, Si Shen, Chen Guo, Chen Guo, Anjie Chen, Anjie Chen, Dongjie Yang, Jian Sun, Yuanyuan Mi   +10 more
doaj   +1 more source

Corrigendum: Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma

Frontiers in Medicine, 2023
Hanwen Lu, Hanwen Lu, Liwei Zhou, Liwei Zhou, Bingchang Zhang, Bingchang Zhang, Yuanyuan Xie, Yuanyuan Xie, Huiyin Yang, Huiyin Yang, Zhanxiang Wang, Zhanxiang Wang, Zhanxiang Wang   +12 more
doaj   +1 more source

Lipoyltransferase 1 Gene Defect Resulting in Fatal Lactic Acidosis in Two Siblings

Case Reports in Obstetrics and Gynecology, 2016
A term male neonate developed severe intractable lactic acidosis on day of life 1 and died the same day at our institution. The family previously lost another term, female newborn on day of life 1 from suspected sepsis at an outside hospital.
Véronique Taché, Liga Bivina, Sophie White, Jeffrey Gregg, Joshua Deignan, Simeon A. Boyadjievd, Francis R. Poulain   +6 more
doaj   +1 more source

Lipidomic Analysis of Plastidial Octanoyltransferase Mutants of Arabidopsis thaliana

Metabolites, 2019
Plant de novo fatty acid synthesis takes place in the plastid using acetyl-coenzyme A (acetyl-CoA) as the main precursor. This first intermediate is produced from pyruvate through the action of the plastidial pyruvate dehydrogenase complex (PDH), which ...
Raquel Martins-Noguerol, Antonio Javier Moreno-Pérez, Sebastien Acket, Salim Makni, Rafael Garcés, Adrián Troncoso-Ponce, Joaquín J. Salas, Brigitte Thomasset, Enrique Martínez-Force   +8 more
doaj   +1 more source

Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients

Frontiers in Cell and Developmental Biology
BackgroundColon adenocarcinoma (COAD) remains a major global health challenge with poor prognosis despite advances in treatment, underscoring the need for new biomarkers. As a novel mode of cell death, cuproptosis is thought to be potentially involved in
Zhanhui Ye, Yixian Song, Mengqing Zhu, Fuying Zheng, Wenjie Qin, Wenjie Qin, Xue Li, Pei Wang, Zihua Li, Kequan Chen, Aimin Li   +10 more
doaj   +1 more source