Results 61 to 70 of about 3,607 (128)

Copper-induced cell death mechanisms and their role in the tumor microenvironment

Frontiers in Cell Death
Copper is an essential cofactor for all organisms. However, it can become toxic if its concentration rises above a specific level. This level is controlled by evolutionary conserved homeostatic mechanisms.
Yujuan Jiao, Hongxin Wang, Meng Zhu, Tengteng Liu, Yuqi Li, Shuo Yang, Minghui Zhang, Lei Zhang   +7 more
doaj   +1 more source

The Potential Mechanism of Cuproptosis in Hemocytes of the Pacific Oyster Crassostrea gigas upon Elesclomol Treatment

Cells
Cuproptosis is a novel cell death dependent on mitochondrial respiration and regulated by copper. While the study of it is mainly focused on tumor therapy, in the present study, two key cuproptosis-related genes, ferredoxin (FDX1) and dihydrolipoamide S ...
Yuxin Zhang, Jiejie Sun, Shurong Li, Lingling Wang, Linsheng Song   +4 more
doaj   +1 more source

Research progress on the regulation of cuproptosis-related genes by non-coding RNAs in tumors

Oncologie
Cuproptosis represents a mechanistically distinct programmed cell death pathway divergent from canonical apoptosis, necrosis, and ferroptosis. This copper-dependent process critically modulates tumorigenesis, malignant progression, and clinical outcomes ...
Du Yuxin, Zhang Zhendong, Cao Mingyuan, Hou Xinrui, Wang Xiaoping   +4 more
doaj   +1 more source

Ferredoxin 1 is essential for embryonic development and lipid homeostasis

eLife
Mammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways ...
Shakur Mohibi, Yanhong Zhang, Vivian Perng, Mingyi Chen, Jin Zhang, Xinbin Chen   +5 more
doaj   +1 more source

A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells

Nature Communications
Proteins with chemically regulatable phase separation are of great interest in the fields of biomolecular condensates and synthetic biology. Intrinsically disordered proteins (IDPs) are the dominating building blocks of biomolecular condensates which ...
Jinglei Nie, Xinyi Zhang, Zhijuan Hu, Wei Wang, Martin A. Schroer, Jie Ren, Dmitri Svergun, Anyang Chen, Peiguo Yang, An-Ping Zeng   +9 more
doaj   +1 more source

Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis

Communications Biology
Cuproptosis, a copper-triggered cell death pathway, holds therapeutic potential for cancers, but its regulatory mechanisms in hepatocellular carcinoma (HCC) remain undefined.
Chutian Wu, Linjing Long, Min Wang, Lianli Shen, Jianjun Hu, Huijun Tang, Shufen Feng, Xiongxiu Liu, Ying Shi, Shaohui Tang, Yanfang Chen   +10 more
doaj   +1 more source

Targeting SERPINB3–MAPK axis-mediated cuproptosis resistance enhances the response to antitumor immunotherapy

Molecular Cancer
Cuproptosis, a newly identified form of cell death, is closely linked to copper homeostasis and protein lipoylation. Using a multi-omics approach, we firstly reveal that SERPINB3 confers cuproptosis resistance in pancreatic cancer and functions as a ...
Xiao-Xiao Huang, Cheng-Ke Xie, Yi-Chao Mo, Wei Li, Yong-Ding Wu, Zhi-Yuan Li, Hao-Xiang Zhang, Ge Li, Long Jin, Xin-Quan Lin, Jian-Fei Hu, Yin-Hao Chen, Hong-Yi Lin, Shun-Cang Zhu, Jin-Peng Lu, Hou-Juan Zhu, Wan-Wan Wang, Yi Huang, Zu-Wei Wang, Long Huang, Dan-Feng Wang, Yi-Feng Tian, Cheng-Yu Liao, Shi Chen   +23 more
doaj   +1 more source

Variants in glycine decarboxylase activate catabolic mechanisms of mitochondrial energy metabolism in the brain. [PDF]

J Biol Chem
Lopez-Ramirez A, Worth AJ, Wang ZL, Yilmaz S, Hayes S, Tang HY, Farris J, Alam MS, Padmanabhan P, Haldar K.   +9 more
europepmc   +1 more source

LIPT1 loss confers replication stress and PARP inhibitor sensitivity through PrimPol-mediated ssDNA gaps. [PDF]

Sci Adv
Shang Z, Chiang JC, Hsu CC, Newman C, Davis AJ, Zhang Y.   +5 more
europepmc   +1 more source

Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase. [PDF]

Sci Adv
Hu Z, Yu J, Liu Z, Jiang M, Zeng AP.
europepmc   +1 more source