Results 31 to 40 of about 22,512 (211)
Frontiers in Molecular Neuroscience, 2021 Glutamate is the major excitatory neurotransmitter in the vertebrate brain and various modifications have been established in the glutamatergic synapses.
Takashi Hayashi
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Palmitoylation and depalmitoylation defects [PDF]
, 2021 Palmitoylation describes the enzymatic attachment of a 16-carbon atom fatty acid to a target protein. Such lipidation events occur in all eukaryotes and can be of reversible (S-palmitoylation) or irreversible (N-palmitoylation) nature.
Hornemann, Thorsten
core
Global, site-specific analysis of neuronal protein S-acylation
Scientific Reports, 2017 Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins +2 more
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Protein palmitoylation in cancer: molecular functions and therapeutic potential
Molecular Oncology, 2023 Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family.
Binhui Zhou +3 more
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The intracellular dynamic of protein palmitoylation [PDF]
, 2010 S-palmitoylation describes the reversible attachment of fatty acids (predominantly palmitate) onto cysteine residues via a labile thioester bond. This posttranslational modification impacts protein functionality by regulating membrane interactions ...
Salaun, Christine +2 more
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Frontiers in Cellular and Infection Microbiology, 2022 Protein palmitoylation—a lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl group—is a significant post-translational biological process. This process regulates the trafficking,
Xiaoling Li +5 more
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Retraction: Palmitoylation of the human prostacyclin receptor. FUNCTIONAL IMPLICATIONS OF PALMITOYLATION AND ISOPRENYLATION. [PDF]
Journal of Biological Chemistry, 2016 We have previously established that isoprenylation of the prostacyclin receptor (IP) is required for its efficient G protein coupling and effector signaling (Hayes, J. S., Lawler, O. A., Walsh, M. T., and Kinsella, B. T. (1999) J. Biol. Chem. 274, 23707-23718).
Sinead M, Miggin +2 more
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Biochemical Characterization of a Palmitoyl Acyltransferase Activity That Palmitoylates Myristoylated Proteins [PDF]
Journal of Biological Chemistry, 1995 Dynamic regulation of signal transduction by reversible palmitoylation-depalmitoylation cycles has been recently described. However, further understanding of fatty acylation reactions has been hampered by our lack of knowledge about the specific transferases and thioesterases involved.
L, Berthiaume, M D, Resh
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Mechanisms and functional implications of ZDHHC5 in cellular physiology and disease
Journal of Lipid ResearchPost-translational lipid modification by palmitoylation is a reversible process crucial for maintaining cellular functionality. The palmitoyl acyltransferase zinc finger Asp-His-His-Cys motif-containing 5 (ZDHHC5) has garnered significant attention due ...
Huicong Liu +4 more
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Palmitoylation of Hedgehog Proteins [PDF]
, 2012 Hedgehog (Hh) proteins are secreted signaling proteins that contain amide-linked palmitate at the N-terminus and cholesterol at the C-terminus. Palmitoylation of Hh proteins is critical for effective long- and short-range signaling. The palmitoylation reaction occurs during transit of Hh through the secretory pathway, most likely in the lumen of the ER.
John A, Buglino, Marilyn D, Resh
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