Results 41 to 50 of about 20,725 (233)

Protein Palmitoylation Modification During Viral Infection and Detection Methods of Palmitoylated Proteins

Frontiers in Cellular and Infection Microbiology, 2022
Protein palmitoylation—a lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl group—is a significant post-translational biological process. This process regulates the trafficking,
Xiaoling Li, Lingyi Shen, Zhao Xu, Wei Liu, Aihua Li, Jun Xu   +5 more
doaj   +1 more source

Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability [PDF]

Cell Death & Differentiation, 2014
The death receptor Fas undergoes a variety of post-translational modifications including S-palmitoylation. This protein acylation has been reported essential for an optimal cell death signaling by allowing both a proper Fas localization in cholesterol and sphingolipid-enriched membrane nanodomains, as well as Fas high-molecular weight complexes.
Rossin, A, Durivault, J, Chakhtoura-Feghali, T, Lounnas, N, Gagnoux-Palacios, L, Hueber, A-O   +5 more
openaire   +3 more sources

CD-MPR: Quo Vadis? [PDF]

, 2003
Lysosomes are membrane-bound organelles that serve in the degradation of many extracellular and intracellular macromolecules. Lysosomal biogenesis depends on the delivery of newly synthesized lysosomal hydrolases. This process requires the acquisition
Stöckli, Jacqueline
core   +1 more source

Biochemical Characterization of a Palmitoyl Acyltransferase Activity That Palmitoylates Myristoylated Proteins [PDF]

Journal of Biological Chemistry, 1995
Dynamic regulation of signal transduction by reversible palmitoylation-depalmitoylation cycles has been recently described. However, further understanding of fatty acylation reactions has been hampered by our lack of knowledge about the specific transferases and thioesterases involved.
L, Berthiaume, M D, Resh
openaire   +2 more sources

Mechanisms and functional implications of ZDHHC5 in cellular physiology and disease

Journal of Lipid Research
Post-translational lipid modification by palmitoylation is a reversible process crucial for maintaining cellular functionality. The palmitoyl acyltransferase zinc finger Asp-His-His-Cys motif-containing 5 (ZDHHC5) has garnered significant attention due ...
Huicong Liu, Shuo Wen, Chang Xu, Xiaohong Kang, Eryan Kong   +4 more
doaj   +1 more source

Retraction: Palmitoylation of the human prostacyclin receptor. FUNCTIONAL IMPLICATIONS OF PALMITOYLATION AND ISOPRENYLATION. [PDF]

Journal of Biological Chemistry, 2016
We have previously established that isoprenylation of the prostacyclin receptor (IP) is required for its efficient G protein coupling and effector signaling (Hayes, J. S., Lawler, O. A., Walsh, M. T., and Kinsella, B. T. (1999) J. Biol. Chem. 274, 23707-23718).
Sinead M, Miggin, Orlaith A, Lawler, B Therese, Kinsella   +2 more
openaire   +3 more sources

Palmitoylation of Hedgehog Proteins [PDF]

, 2012
Hedgehog (Hh) proteins are secreted signaling proteins that contain amide-linked palmitate at the N-terminus and cholesterol at the C-terminus. Palmitoylation of Hh proteins is critical for effective long- and short-range signaling. The palmitoylation reaction occurs during transit of Hh through the secretory pathway, most likely in the lumen of the ER.
John A, Buglino, Marilyn D, Resh
openaire   +2 more sources

Palmitoylation-prone APP mutants exhibit increased APP dimerization compared to wtAPP.

, 2016
A. Schematic representation of the Cys to Ser mutants of APP used for the following co-immunoprecipitation assays. B. Co-immunoprecipitation assay in cells co-expressing APPV5 and HA-APPY and its mutants containing indicated Cys to Ser substitution.
Dora M. Kovacs (3359177), Cory Barren (3359183), Raja Bhattacharyya (3359186), Rebecca H. Fenn (3359180), Rudolph E. Tanzi (178268)   +4 more
core   +1 more source

Palmitoylation of BK channels [PDF]

, 2010
Palmitoylation is a post-translational modification that has been implicated in the control of multiple proteins, including ion channels. S-Palmitoylation is a lipophilic modification that involves the attachment of palmitate through a thioester linkage ...
Jeffries, Owen, Shipston, Michael
core   +1 more source

Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases

Frontiers in Immunology
Protein palmitoylation is a reversible lipid modification in which palmitoyl esters are covalently attached to cysteine residues of proteins. It controls various cellular physiological processes and alters protein stability, conformation, localization ...
Rong Chen, Rong Chen, Xiaohua Tang, Ying Wang, Bo Wang, Fei Mao, Fei Mao   +6 more
doaj   +1 more source