Results 41 to 50 of about 22,512 (211)

Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability [PDF]

Cell Death & Differentiation, 2014
The death receptor Fas undergoes a variety of post-translational modifications including S-palmitoylation. This protein acylation has been reported essential for an optimal cell death signaling by allowing both a proper Fas localization in cholesterol and sphingolipid-enriched membrane nanodomains, as well as Fas high-molecular weight complexes.
Rossin, A, Durivault, J, Chakhtoura-Feghali, T, Lounnas, N, Gagnoux-Palacios, L, Hueber, A-O   +5 more
openaire   +3 more sources

Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme

Molecular Therapy: Oncolytics, 2020
Glioblastoma multiforme (GBM) almost invariably acquires an invasive phenotype, resulting in limited therapeutic options. Protein palmitoylation markedly affects tumorigenesis and malignant progression in GBM.
Xueran Chen, Hao Li, Xiaoqing Fan, Chenggang Zhao, Kaiqin Ye, Zhiyang Zhao, Lizhu Hu, Huihui Ma, Hongzhi Wang, Zhiyou Fang   +9 more
doaj   +1 more source

Palmitoylation-prone APP mutants exhibit increased APP dimerization compared to wtAPP.

, 2016
A. Schematic representation of the Cys to Ser mutants of APP used for the following co-immunoprecipitation assays. B. Co-immunoprecipitation assay in cells co-expressing APPV5 and HA-APPY and its mutants containing indicated Cys to Ser substitution.
Dora M. Kovacs (3359177), Cory Barren (3359183), Raja Bhattacharyya (3359186), Rebecca H. Fenn (3359180), Rudolph E. Tanzi (178268)   +4 more
core   +1 more source

Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases

Frontiers in Immunology
Protein palmitoylation is a reversible lipid modification in which palmitoyl esters are covalently attached to cysteine residues of proteins. It controls various cellular physiological processes and alters protein stability, conformation, localization ...
Rong Chen, Rong Chen, Xiaohua Tang, Ying Wang, Bo Wang, Fei Mao, Fei Mao   +6 more
doaj   +1 more source

Protein cysteine palmitoylation in immunity and inflammation

, 2021
Protein cysteine palmitoylation, or S-palmitoylation, has been known for about 40 years and thousands for proteins in humans are known to be modified.
Lin, Hening, Hening Lin
core   +1 more source

Palmitoylation in Renal Physiology and Pathology

Biomolecules
Palmitoylation is a critical post-translational modification that involves the covalent binding of palmitic acid to cysteine residues within proteins.
Jingru Ma, Zhen Zhang, Jiaqi Guo, Hu Cai, Jian Yao, Dahai Yang, Huiyuan Zhu, Haijing Liu, Changhe Wang, Hongbo Xu   +9 more
doaj   +1 more source

CD-MPR: Quo Vadis? [PDF]

, 2003
Lysosomes are membrane-bound organelles that serve in the degradation of many extracellular and intracellular macromolecules. Lysosomal biogenesis depends on the delivery of newly synthesized lysosomal hydrolases. This process requires the acquisition
Stöckli, Jacqueline
core   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

S-palmitoylation of MAP kinase is essential for fungal virulence

mBio
S-palmitoylation is an important reversible protein post-translational modification in organisms. However, its role in fungi is uncertain. Here, we found the treatment of the rice false fungus Ustilaginoidea virens with S-palmitoylation inhibitor 2 BP ...
Yuhang Duan, Pingping Li, Deyao Zhang, Lili Wang, Yuan Fang, Hong Hu, Qiulu Mao, Xiaolan Zhou, Panpan Zhao, Xuechun Li, Jinfeng Wei, Jintian Tang, Li Pan, Hao Liu, Xiaolin Chen, Xiaoyang Chen, Tom Hsiang, Junbin Huang, Lu Zheng   +18 more
doaj   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source