Results 1 to 10 of about 21,089,371 (171)
Recent advances in S-palmitoylation and its emerging roles in human diseases
Journal of Hematology and OncologyS-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions.
Xiangxiang Zhou, Juanjuan Shang
exaly +3 more sources
PRDX6: A protein bridging S-palmitoylation and diabetic neuropathy
Frontiers in Endocrinology, 2022 Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes. It can affect both the peripheral and central nervous systems, leading to pain, decreased motility, cognitive decline, and dementia.
Yan Cao +3 more
doaj +3 more sources
Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells. [PDF]
PLoS ONE, 2013 Recently, one of the interferon-induced transmembrane (IFITM) family proteins, IFITM3, has become an important target for the activity against influenza A (H1N1) virus infection.
Takashi Tsukamoto +6 more
doaj +5 more sources
PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism
iScience, 2023 Summary: Ovarian granulosa cells (GCs) in the follicle are the important mediator of steroidogenesis and foster oocyte maturation. Evidences suggested that the function of GCs could be regulated by S-palmitoylation.
Tongmin Xue +13 more
doaj +1 more source
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe
Life Science Alliance, 2023 The vital role of S-palmitoylation in cell differentiation is demonstrated in the fission yeast by showing that the modification is required at multiple meiotic stages including mating and karyogamy.
Thanh-Vy Pham +4 more
doaj +1 more source
S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
Cells, 2023 Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto ...
Anna Buszka +4 more
doaj +1 more source
eLife, 2022 Protein S-palmitoylation is a reversible post-translational lipid modification that plays a critical role in neuronal development and plasticity, while dysregulated S-palmitoylation underlies a number of severe neurological disorders.
Angela R Wild +7 more
doaj +1 more source
Frontiers in Physiology, 2023 The reversible lipid modification protein S-palmitoylation can dynamically modify the localization, diffusion, function, conformation and physical interactions of substrate proteins.
Angela R. Wild +6 more
doaj +1 more source
Frontiers in Physiology, 2022 S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date.
Alice Main +11 more
doaj +1 more source