Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses [PDF]
BiomoleculesProtein S-palmitoylation is a pivotal yet poorly integrated research field in dermatology. This reversible post-translational lipid modification primarily occurs on cysteine residues and is principally catalyzed by zinc finger and Asp-His-His-Cys DHHC ...
Yanhai Feng +9 more
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S-palmitoylation of MAP kinase is essential for fungal virulence [PDF]
mBioS-palmitoylation is an important reversible protein post-translational modification in organisms. However, its role in fungi is uncertain. Here, we found the treatment of the rice false fungus Ustilaginoidea virens with S-palmitoylation inhibitor 2 BP ...
Yuhang Duan +18 more
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Recent advances in S-palmitoylation and its emerging roles in human diseases [PDF]
Journal of Hematology & OncologyS-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions.
Juanjuan Shang +2 more
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Advances in targeting protein S-palmitoylation in tumor immunity and therapy [PDF]
Frontiers in OncologyS-palmitoylation is a reversible and dynamic post-translational modification of proteins. A palmitoyl group is covalently attached to a cysteine residue of the protein by a thioester link.
Miaomiao Han +13 more
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From lipid modification to cell death: the diverse roles of S-palmitoylation in cell fate decisions [PDF]
Cell Communication and SignalingS-palmitoylation is a dynamic, reversible lipid modification that plays a crucial role in the regulation of various types of cell death. However, systematic insights into how S-palmitoylation modifications integrate and mediate crosstalk among diverse ...
Yue Zhu +5 more
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Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart [PDF]
Cellular and Molecular Life SciencesExcessive accumulation of long-chain fatty acids (LCFAs) in cardiomyocytes leads to cardiac lipid-induced insulin resistance (CLIR), impairing insulin signaling and glucose uptake.
Francesco Schianchi +13 more
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Bridging metabolic reprogramming and targeted therapy: the critical role of S-palmitoylation in cancer [PDF]
Frontiers in Cell and Developmental BiologyMetabolic reprogramming provides cancer cells with excess fatty acids (FA) to adapt to metabolic stress; however, the precise mechanisms by which these lipid substrates are converted into sustained oncogenic signaling outputs remain incompletely ...
Yan Sun +8 more
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The Unconventional Role of ABHD17A in Increasing the S-Palmitoylation and Antiviral Activity of IFITM1 by Downregulating ABHD16A [PDF]
BiomoleculesThe broad-spectrum antiviral functions of interferon-inducible transmembrane 1 (IFITM1) rely on S-palmitoylation post-translational modification.
Xuemeng Shi +11 more
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Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity [PDF]
Cellular and Molecular Life SciencesBackground Synaptic plasticity, a fundamental process underlying learning and memory, depends on activity-driven changes in neural connectivity. S-palmitoylation, a reversible post-translational lipid modification, modulates synaptic protein function by ...
Agata Pytyś +15 more
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S-palmitoylation and depalmitoylation at the interface of animal virus-host interactions [PDF]
Frontiers in Cellular and Infection MicrobiologyReversible protein S-palmitoylation, mediated by protein acyl transferases (PATs) and depalmitoylases, is essential for regulating numerous biological processes, including subcellular localization, protein stability, enzymatic activity, and protein ...
Rui-Qin Xu +12 more
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