Results 41 to 50 of about 15,826,951 (219)

Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis [PDF]

, 2012
Recently, mutations in the DNAJC5 gene encoding cysteine-string protein alpha (CSPα) were identified to cause the neurodegenerative disorder adult-onset neuronal ceroid lipofuscinosis.
Greaves, J., Chamberlain, Luke, Chamberlain, L. H., Grefen, C., Lemonidis, K., Cruchaga, Carlos, Greaves, Jennifer, Grefen, Christopher, Lemonidis, Kimon, Gorleku, Oforiwa, Cruchaga, C., Gorleku, O. A.   +11 more
core   +1 more source

CellPalmSeq: A curated RNAseq database of palmitoylating and de-palmitoylating enzyme expression in human cell types and laboratory cell lines

Frontiers in Physiology, 2023
The reversible lipid modification protein S-palmitoylation can dynamically modify the localization, diffusion, function, conformation and physical interactions of substrate proteins.
Angela R. Wild, Peter W. Hogg, Stephane Flibotte, Shruti Kochhar, Rocio B. Hollman, Kurt Haas, Shernaz X. Bamji   +6 more
doaj   +1 more source

The role of s-palmitoylation in neurological diseases: implication for zDHHC family. [PDF]

Front Pharmacol, 2023
S-palmitoylation is a reversible posttranslational modification, and the palmitoylation reaction in human-derived cells is mediated by the zDHHC family, which is composed of S-acyltransferase enzymes that possess the DHHC (Asp-His-His-Cys) structural domain.
Liao D, Huang Y, Liu D, Zhang H, Shi X, Li X, Luo P.   +6 more
europepmc   +4 more sources

S-palmitoylation coordinates the trafficking of ATG9A to mediate autophagy initiation. [PDF]

Autophagy
Macroautophagy (hereafter autophagy), a major intracellular catabolic process, is evolutionarily conserved from yeast to mammals and is associated with a broad range of human diseases. Autophagy is morphologically characterized by the formation of double-membrane autophagosomes.
Xia F, Li W, Wang W, Liu J, Li X, Cai J, Shan H, Cai Z, Cui J.   +8 more
europepmc   +3 more sources

S-Palmitoylation and S-Oleoylation of Rabbit and Pig Sarcolipin [PDF]

Journal of Biological Chemistry, 2014
Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of animals. We find that native rabbit SLN is modified by a fatty acid anchor on Cys-9 with a palmitic acid in about 60% and, surprisingly, an oleic acid in the remaining 40%. SLN used for co-crystallization with SERCA1a (Winther, A.
Montigny, Cédric, Decottignies, Paulette, Le Maréchal, Pierre, Capy, Pierre, Bublitz, Maike, Olesen, Claus, Møller, Jesper Vuust, Nissen, Poul, Le Maire, Marc   +8 more
openaire   +2 more sources

S-palmitoylation determines TMEM55B-dependent positioning of lysosomes

Journal of Cell Science, 2021
ABSTRACT The spatiotemporal cellular distribution of lysosomes depends on active transport mainly driven by microtubule motors such as kinesins and dynein. Different protein complexes attach these molecular motors to their vesicular cargo. TMEM55B (also known as PIP4P1), as an integral lysosomal membrane protein, is a component of such a
Sönke Rudnik, Saskia Heybrock, Paul Saftig, Markus Damme   +3 more
openaire   +2 more sources

Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies

Frontiers in Physiology, 2022
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date.
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller   +11 more
doaj   +1 more source

Cytoplasmic tail determines the membrane trafficking and localization of SARS-CoV-2 spike protein

Frontiers in Molecular Biosciences, 2022
The spike (S) glycoprotein of SARS-CoV-2 mediates viral entry through associating with ACE2 on host cells. Intracellular trafficking and palmitoylation of S protein are required for its function.
Qinlin Li, Qinlin Li, Qinlin Li, Yihan Liu, Yihan Liu, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +7 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Voltage-Gated Sodium Channel Nav1.6 S-Palmitoylation Regulates Channel Functions and Neuronal Excitability

, 2020
Indiana University-Purdue University Indianapolis (IUPUI)The voltage-gated sodium channels (VGSCs) are critical determinants of neuronal excitability. They set the threshold for action potential generation.
Pan, Yanling
core   +1 more source