Results 1 to 10 of about 473 (132)
Critical Reviews in Microbiology, 2020 Post-translational modifications (PTMs) play a pivotal role in expanding functional protein diversity. During viral infection, pathogen-associated molecular patterns derived from viruses are recognized by pattern recognition receptors present in the membrane surface and the cytoplasm of infected cells, which subsequently induces the antiviral innate ...
Yi Li, Chunfu Zheng
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In Vitro Assays to Monitor the Enzymatic Activities of zDHHC Protein Acyltransferases
, 2019 A family of zDHHC protein acyltransferase (PAT) enzymes catalyze the S-palmitoylation of target proteins via a two-step mechanism. The first step involves transfer of palmitate from the palmitoyl-CoA donor to the active site cysteine of the zDHHC PAT enzyme, releasing reduced CoA (CoASH).
David A. Mitchell +2 more
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Cancer Gene Therapy, 2022 We have shown that insulin-like growth factor-1 (IGF-1) induces palmitoylation turnover of Flotillin-1 (Flot-1) in the plasma membrane (PM) for cell proliferation, after IGF-1 receptor (IGF-1R) signaling activation. However, the enzymes responsible for the turnover have not been identified.
Hayeong Kwon +4 more
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2018 Gijs R. van den Brink +1 more
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The GolgiS-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity andS-acylation activity [PDF]
Molecular Biology of the Cell, 2014 S-acylation, the attachment of fatty acids onto cysteine residues, regulates protein trafficking and function and is mediated by a family of zDHHC enzymes. The S-acylation of peripheral membrane proteins has been proposed to occur at the Golgi, catalyzed by an S-acylation machinery that displays little substrate specificity. To advance understanding of
Kimon Lemonidis +4 more
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Some of the next articles are maybe not open access.
Regulation of dendrite morphology and excitatory synapse formation by zDHHC15
Journal of Cell Science, 2019Bhavin S Shāh, Shernaz X Bamji
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