A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification [PDF]
Journal of Lipid ResearchAt least 10% of proteins constituting the human proteome are subject to S-acylation by a long-chain fatty acid, thioesterified to a Cys thiol side chain.
Takehiko Ueyama +2 more
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Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond [PDF]
Cells, 2023 Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain—a 16-carbon palmitate acid—to the specific cysteine residues on target proteins.
Mingli Li, Chun-Wei Chen
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Substrate recruitment by zDHHC protein acyltransferases [PDF]
Open Biology, 2021 Protein palmitoylation is the post-translational attachment of fatty acids, most commonly palmitate (C16 : 0), onto a cysteine residue of a protein. This reaction is catalysed by a family of integral membrane proteins, the zDHHC protein acyltransferases (
Martin Ian P. Malgapo, Maurine E. Linder
doaj +4 more sources
Bioinformatics Analysis of the Prognostic and Biological Significance of ZDHHC-Protein Acyltransferases in Kidney Renal Clear Cell Carcinoma [PDF]
Frontiers in Oncology, 2020 ZDHHC-protein acyltransferases (ZDHHCs) are a family of 23 signature Asp-His-His-Cys (DHHC) domain-containing enzymes that mediate palmitoylation by covalent attachment of the 16-carbon fatty acid palmitate to thiol groups of specific cysteine residues ...
Yamei Han, Mingming Xiao
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RETRACTED ARTICLE: Palmitoyl transferases act as novel drug targets for pancreatic cancer
Journal of Translational Medicine, 2023 Background Pancreatic adenocarcinoma (PAAD) is one of the most leading causes of cancer-related death across the world with the limited efficiency and response rate of immunotherapy.
Zhiqing Lin +3 more
doaj +3 more sources
Construction and validation of prognostic risk model for hepatocellular carcinoma based on biological analysis of palmitoyl-associated enzyme long-chain non-coding RNA [PDF]
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To explore the effect of screening the expression of long non-coding RNA (lncRNA) related to palmitoylation on prognosis of liver cancer based on The Cancer Genome Atlas (TCGA) database and construct a risk prediction model in liver cancer ...
YU Li +4 more
doaj +2 more sources
STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity [PDF]
Advanced Science, 2023 STING is an innate immune sensor for immune surveillance of viral/bacterial infection and maintenance of an immune‐friendly microenvironment to prevent tumorigenesis.
Zhichuan Zhu +13 more
doaj +4 more sources
Molecular Therapy - Nucleic Acids, 2022 High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune ...
Ze-Fen Wang, Li Zhiqiang, Feng Tang
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ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma
BMC Cancer, 2023 Background Glioma is the most common and aggressive tumor in the adult brain. Recent studies have indicated that Zinc finger DHHC-type palmitoyltransferases (ZDHHCs) play vital roles in regulating the progression of glioma.
Ze-Fen Wang, Li Zhiqiang, Feng Tang
exaly +2 more sources
S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK) channels [PDF]
Frontiers in Physiology, 2014 Mechanisms that control surface expression and/or activity of large conductance calcium-activated potassium (BK) channels are important determinants of their (patho)physiological function.
Michael J Shipston
doaj +2 more sources