Results 1 to 10 of about 624,759 (269)

Characterization of a SAM-dependent fluorinase from a latent biosynthetic pathway for fluoroacetate and 4-fluorothreonine formation in Nocardia brasiliensis [v1; ref status: indexed, http://f1000r.es/2tz]

F1000Research, 2014
Fluorination has been widely used in chemical synthesis, but is rare in nature. The only known biological fluorination scope is represented by the fl pathway from Streptomyces cattleya that produces fluoroacetate (FAc) and 4-fluorothreonine (4-FT).
Yaya Wang, Zixin Deng, Xudong Qu
doaj   +1 more source

IFIT3 promotes lymph node metastasis by interacting with LASP1 to activate FAK-ERK signaling in esophageal squamous cell carcinoma

Cell Death and Disease
Lymph node metastasis (LNM) is an important cause of poor prognosis in patients with esophageal squamous cell carcinoma (ESCC). However, the mechanism of LNM in ESCC has not been elucidated.
Qixiao Cui, Xiaolin Zhou, Xiaojie Chen, Xiaochuan Zhao, Rui Zhang, Jince Wang, Xiaoli Li, Guoli Wang, Bohan Li, Minjing Li, Jiajia Chen, Xihang Gao, Yanbing Shi, Wenting Li, Pan Hong, Defang Li   +15 more
doaj   +1 more source

Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090

Microbial Cell Factories, 2018
Background Tubercidin (TBN), an adenosine analog with potent antimycobacteria and antitumor bioactivities, highlights an intriguing structure, in which a 7-deazapurine core is linked to the ribose moiety by an N-glycosidic bond.
Yan Liu, Rong Gong, Xiaoqin Liu, Peichao Zhang, Qi Zhang, You-Sheng Cai, Zixin Deng, Margit Winkler, Jianguo Wu, Wenqing Chen   +9 more
doaj   +1 more source

Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis

Nature Communications
To the best of our knowledge, enzymes that catalyse intramolecular Diels-Alder ([4+2] cycloaddition) reactions are frequently reported in natural product biosynthesis; however, no native enzymes utilising Lewis acid catalysis have been reported ...
Yu Zheng, Katsuyuki Sakai, Kohei Watanabe, Hiroshi Takagi, Yumi Sato-Shiozaki, Yuko Misumi, Yohei Miyanoiri, Genji Kurisu, Toshihiko Nogawa, Ryo Takita, Shunji Takahashi   +10 more
doaj   +1 more source

Engineered AcrIIA5 for optogenetic control of CRISPR‐Cas9‐based genome editing

mLife
The CRISPR‐Cas9 system has been proven to be a powerful tool for gene editing in living cells and shows great potential in genetic disease treatment. Anti‐CRISPR (Acr)‐based optogenetic tools could spatiotemporally regulate the activity of CRISPR‐Cas9 ...
Qi Chen, Jia Yao, Yingfan Lu, Ruikang Qiu, Zixin Deng, Yuhui Sun   +5 more
doaj   +1 more source

Advances in the Molecular Modification of Microbial ω-Transaminases for Asymmetric Synthesis of Bulky Chiral Amines

Microorganisms
ω-Transaminases are biocatalysts capable of asymmetrically synthesizing high-value chiral amines through the reductive amination of carbonyl compounds, and they are ubiquitously distributed across diverse microorganisms.
Xinxing Gao, Qingming He, Hailong Chen, Wangshui Cai, Long Xu, Xin Zhang, Nianqing Zhu, Shoushuai Feng   +7 more
doaj   +1 more source

Oral N-Acetylneuraminic Acid Promotes Spot Brightening and Enhances Hydration and Elasticity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Cosmetics
Background: N-Acetylneuraminic acid (Neu5Ac), the predominant form of sialic acid, exhibits potent antioxidant, anti-inflammatory, and anti-glycation properties in preclinical studies, suggesting potential dermatological benefits.
Zicun Lin, Min Xiao, Na Li, Libin Tu, Hao Shi, Menghui Li, Lixia Yuan, Xiangyu Li   +7 more
doaj   +1 more source

Analysing a Group of Homologous BAHD Enzymes Provides Insights into the Evolutionary Transition of Rosmarinic Acid Synthases from Hydroxycinnamoyl-CoA:Shikimate/Quinate Hydroxycinnamoyl Transferases

Plants
The interplay of various enzymes and compounds gives rise to the intricate secondary metabolic networks observed today. However, the current understanding of their formation and expansion remains limited. BAHD acyltransferases play important roles in the
Jiali Zhou, Xiaofang Zou, Zixin Deng, Lian Duan   +3 more
doaj   +1 more source

Deep Learning-Based Self-Adaptive Evolution of Enzymes

Pharmaceutical Fronts
Biocatalysis has been widely used to prepare drug leads and intermediates. Enzymatic synthesis has advantages, mainly in terms of strict chirality and regional selectivity compared with chemical methods.
Shuiqin Jiang, Dong Yi
doaj   +1 more source

Metabolomics reveal drought-stress responses in guayule, a semi-arid rubber crop. [PDF]

Metabolomics
Phan H, Abdel-Haleem H.
europepmc   +1 more source