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Advanced Strategies for Production of Natural Products in Yeast
iScience, 2020 Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading ...
Ruibing Chen +3 more
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Expanding metabolic engineering algorithms using feasible space and shadow price constraint modules
Metabolic Engineering Communications, 2014 While numerous computational methods have been developed that use genome-scale models to propose mutants for the purpose of metabolic engineering, they generally compare mutants based on a single criteria (e.g., production rate at a mutant׳s maximum ...
Christopher J. Tervo, Jennifer L. Reed
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Metabolic engineering: Use of system-level approaches and application to fuel production in Escherichia coli [PDF]
, 2013 Metabolic engineering was formally defined more than two decades ago (Bailey, 1991) and it is now an established discipline. Metabolic engineering is generally defined as the directed improvement of product formation or cellular properties through the ...
González, Ramón
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Biology, 2021 β-alanine is widely used as an intermediate in industrial production. However, the low production of microbial cell factories limits its further application.
Jian Xu, Li Zhou, Zhemin Zhou
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Aromatic Plants Metabolic Engineering: A Review
Agronomy, 2022 Secondary metabolites of aromatic plants are used in many health applications as drugs, pheromones, insecticides, fragrances, and antioxidants. Due to the huge commercial demand for these secondary metabolites, the need to overcome the insufficient ...
Olga V. Shelepova +6 more
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Synthetic and Systems Biotechnology, 2018 Advances in metabolic engineering and synthetic biology have facilitated the manufacturing of many valuable-added compounds and commodity chemicals using microbial cell factories in the past decade.
Lihong Jiang +3 more
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Systems Metabolic Engineering of Industrial Microorganisms
Microorganisms, 2023 The green and sustainable production of chemicals, materials, fuels, food, and pharmaceuticals has become a key solution to the global energy and environmental crisis [...]
Xueqin Lv +3 more
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Advances on systems metabolic engineering of Bacillus subtilis as a chassis cell
Synthetic and Systems Biotechnology, 2020 The Gram-positive model bacterium Bacillus subtilis, has been broadly applied in various fields because of its low pathogenicity and strong protein secretion ability, as well as its well-developed fermentation technology. B.
Mengjie Xiang, Qian Kang, Dawei Zhang
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Grounding knowledge and normative valuation in agent-based action and scientific commitment [PDF]
, 2018 Philosophical investigation in synthetic biology has focused on the knowledge-seeking questions pursued, the kind of engineering techniques used, and on the ethical impact of the products produced.
A Clark +50 more
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The Studies in Constructing Yeast Cell Factories for the Production of Fatty Acid Alkyl Esters
Frontiers in Bioengineering and Biotechnology, 2022 Fatty acid alkyl esters have broad applications in biofuels, lubricant formulas, paints, coatings, and cosmetics. Traditionally, these esters are mostly produced through unsustainable and energy-intensive processes.
Yang Zhang +4 more
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