Results 11 to 20 of about 330,730 (300)

The logics of metabolic regulation in bacteria challenges biosensor-based metabolic engineering

Microbial Cell, 2017
Synthetic Biology (SB) aims at the rational design and engineering of novel biological functions and systems. By facilitating the engineering of living organisms, SB promises to facilitate the development of many new applications for health ...
Matthieu Jules
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Single cell mutant selection for metabolic engineering of actinomycetes [PDF]

, 2022
Actinomycetes are important producers of pharmaceuticals and industrial enzymes. However, wild type strains require laborious development prior to industrial usage.
Fewer David P., Rahkila Jani, Baral Bikash, Akhgari Amir., Koroleva Arina, Metsä-Ketelä Mikko, Siitonen Vilja, Melançon Charles E.   +7 more
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Engineering yeast for high-level production of diterpenoid sclareol [PDF]

, 2023
The diterpenoid sclareol is an industrially important precursor for alternative sustainable supply of ambergris. However, its current production from plant extraction is neither economical nor environmental-friendly, since it requires laborious and cost ...
Yu, Wei,, Yu, Wei, Nielsen, Jens B, Chen, Yu,, Luan, Hongwei,, Zhou, Yongjin, Chen, Yu, Zhao, Zongbao K.,, Yang, Shan, Luan, Hongwei, Zhou, Yongjin,, Yang, Shan,, Cao, Xuan,, Zhao, Zongbao K., Nielsen, Jens B,, Cao, Xuan   +15 more
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Microbial cell factories based on filamentous bacteria, yeasts, and fungi

Microbial Cell Factories, 2023
Background Advanced DNA synthesis, biosensor assembly, and genetic circuit development in synthetic biology and metabolic engineering have reinforced the application of filamentous bacteria, yeasts, and fungi as promising chassis cells for chemical ...
Qiang Ding, Chao Ye
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Metabolic engineering of sesquiterpene metabolism in yeast [PDF]

Biotechnology and Bioengineering, 2006
AbstractTerpenes are structurally diverse compounds that are of interest because of their biological activities and industrial value. These compounds consist of chirally rich hydrocarbon backbones derived from terpene synthases, which are subsequently decorated with hydroxyl substituents catalyzed by terpene hydroxylases.
Shunji, Takahashi, Yunsoo, Yeo, Bryan T, Greenhagen, Tom, McMullin, Linsheng, Song, Julie, Maurina-Brunker, Reinhardt, Rosson, Joseph P, Noel, Joe, Chappell   +8 more
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Advances in the optimization of central carbon metabolism in metabolic engineering

Microbial Cell Factories, 2023
Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic process in the activities of living organisms that maintains normal cellular growth.
Zhenke Wu, Xiqin Liang, Mingkai Li, Mengyu Ma, Qiusheng Zheng, Defang Li, Tianyue An, Guoli Wang   +7 more
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Characterizing and engineering promoters for metabolic engineering of Ogataea polymorpha

Synthetic and Systems Biotechnology, 2022
Bio-manufacturing via microbial cell factory requires large promoter library for fine-tuned metabolic engineering. Ogataea polymorpha, one of the methylotrophic yeasts, possesses advantages in broad substrate spectrum, thermal-tolerance, and capacity to ...
Chunxiao Yan, Wei Yu, Xiaoxin Zhai, Lun Yao, Xiaoyu Guo, Jiaoqi Gao, Yongjin J. Zhou   +6 more
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Metabolic Engineering of Yeast

, 2021
This chapter focuses on a few examples that can serve as illustrations of how powerful yeast metabolic engineering stands today. Yeast, especially S. cerevisiae, plays an essential role in bioethanol production.
Jens Nielsen, Ishchuk, Olena,, Li, Xiaowei, Yun Chen, Xiaowei Li, Liu, Quanli, Otto, Maximilian, Nielsen, Jens B, Siewers, Verena,, Chen, Yun,, Otto, Maximilian,, Verena Siewers, Liu, Yi, Liu, Quanli,, Rui Pereira, Quanli Liu, Olena P. Ishchuk, Ishchuk, Olena, Pereira, Rui,, Li, Xiaowei,, Siewers, Verena, Maximilian Otto, Pereira, Rui, Chen, Yun, Liu, Yi,, Nielsen, Jens B,, Yi Liu   +26 more
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The LASER database: Formalizing design rules for metabolic engineering

Metabolic Engineering Communications, 2015
The ability of metabolic engineers to conceptualize, implement, and evaluate strain designs has dramatically increased in the last decade. Unlike other engineering fields, no centralized, open-access, and easily searched repository exists for cataloging ...
James D. Winkler, Andrea L. Halweg-Edwards, Ryan T. Gill   +2 more
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Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene Hyper-Producers [PDF]

, 2011
Background: Metabolic engineering is an attractive approach in order to improve the microbial production of drugs. Triterpenes is a chemically diverse class of compounds and many among them are of interest from a human health perspective.
Otero, Jose M., Otero, JM, Koetter, P, Jens Nielsen, Semba, Saori, Tetsuo Kushiro, Karina M Madsen, Nielsen, Jens B, Ebizuka, Yutaka, Jose M. Otero, Kötter, Peter, Gupta D. B. R. K. Udatha, Udatha, Gupta D. B. R. K., Semba, S, Yutaka Ebizuka, Otero Jose M., Jose M Otero, Nielsen, Jens, Panagiotou, Gianni, Panagiotou Gianni, Nielsen, J, Panagiotou, G, Gianni Panagiotou, Madsen Karina M., Udatha Gupta D. B. R. K., Semba Saori, Udatha, Gupta, Madsen, KM, Ebizuka, Y, Madsen, Karina Marie, Madsen, Karina M., Karina M. Madsen, Saori Semba, Udatha, GDBRK, Koetter Peter, Otero, Jos\ue9 Manuel, Otero Romero, José Manuel, Kushiro Tetsuo, Gupta D B R K Udatha, Ebizuka Yutaka, Kushiro, Tetsuo, Koetter, Peter, Kushiro, T, Udatha, D.B.R.K. Gupta, Nielsen Jens, Nielsen, Jens B., Peter Koetter   +46 more
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