Results 41 to 50 of about 9,631,074 (339)
Characterizing and engineering promoters for metabolic engineering of Ogataea polymorpha
Synthetic and Systems Biotechnology, 2022 Bio-manufacturing via microbial cell factory requires large promoter library for fine-tuned metabolic engineering. Ogataea polymorpha, one of the methylotrophic yeasts, possesses advantages in broad substrate spectrum, thermal-tolerance, and capacity to ...
Chunxiao Yan +6 more
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Metabolic engineering of sesquiterpene metabolism in yeast [PDF]
Biotechnology and Bioengineering, 2006 AbstractTerpenes are structurally diverse compounds that are of interest because of their biological activities and industrial value. These compounds consist of chirally rich hydrocarbon backbones derived from terpene synthases, which are subsequently decorated with hydroxyl substituents catalyzed by terpene hydroxylases.
Shunji, Takahashi +8 more
openaire +2 more sources
Metabolomics and modelling approaches for systems metabolic engineering
Metabolic Engineering Communications, 2022 Metabolic engineering involves the manipulation of microbes to produce desirable compounds through genetic engineering or synthetic biology approaches.
J. K. Khanijou +9 more
semanticscholar +1 more source
The LASER database: Formalizing design rules for metabolic engineering
Metabolic Engineering Communications, 2015 The ability of metabolic engineers to conceptualize, implement, and evaluate strain designs has dramatically increased in the last decade. Unlike other engineering fields, no centralized, open-access, and easily searched repository exists for cataloging ...
James D. Winkler +2 more
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Biology, 2021 β-alanine is widely used as an intermediate in industrial production. However, the low production of microbial cell factories limits its further application.
Jian Xu, Li Zhou, Zhemin Zhou
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Metabolic Engineering of Yeast
, 2021 This chapter focuses on a few examples that can serve as illustrations of how powerful yeast metabolic engineering stands today. Yeast, especially S. cerevisiae, plays an essential role in bioethanol production.
Jens Nielsen +26 more
core +1 more source
Machine learning for metabolic engineering: A review.
Metabolic Engineering, 2020 Machine learning provides researchers a unique opportunity to make metabolic engineering more predictable. In this review, we offer an introduction to this discipline in terms that are relatable to metabolic engineers, as well as providing in-depth ...
Christopher E. Lawson +14 more
semanticscholar +1 more source
Advanced Strategies for Production of Natural Products in Yeast
iScience, 2020 Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading ...
Ruibing Chen +3 more
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Expanding metabolic engineering algorithms using feasible space and shadow price constraint modules
Metabolic Engineering Communications, 2014 While numerous computational methods have been developed that use genome-scale models to propose mutants for the purpose of metabolic engineering, they generally compare mutants based on a single criteria (e.g., production rate at a mutant׳s maximum ...
Christopher J. Tervo, Jennifer L. Reed
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Metabolic engineering of Yarrowia lipolytica for terpenoids production: advances and perspectives
Critical Reviews in Biotechnology, 2021 Terpenoids are a large family of natural products with diversified structures and functions that are widely used in the food, pharmaceutical, cosmetic, and agricultural fields.
Ge Zhang +5 more
semanticscholar +1 more source