Results 41 to 50 of about 330,730 (300)
Production of fatty acid-derived valuable chemicals in synthetic microbes
Frontiers in Bioengineering and Biotechnology, 2014 Fatty acid derivatives, such as hydroxy fatty acids, fatty alcohols, fatty acid methyl/ethyl esters and fatty alka(e)nes, have a wide range of industrial applications including plastics, lubricants and fuels.
Ai-Qun eYu +8 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Modeling the metabolic dynamics at the genome-scale by optimized yield analysis [PDF]
, 2023 The hybrid cybernetic model (HCM) approach is a dynamic modeling framework that integrates enzyme synthesis and activity regulation. It has been widely applied in bioreaction engineering, particularly in the simulation of microbial growth in different ...
Luo, Hao +7 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Auxin-mediated protein depletion for metabolic engineering in terpene-producing yeast
Nature Communications, 2021 Loss-of-function experiments are used in metabolic engineering to understand and optimise metabolism. Here, the authors apply auxin inducible protein degradation to test different metabolic engineering strategies for improved terpenoid production in ...
Zeyu Lu +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Systems biology approaches for chemical engineering [PDF]
, 2011 Biological systems are becoming of central interest also in fields which go beyond science and medicine scopes, such as chemical engineering. In the last decades, some complex biological systems have been considered for large scale chemicals production ...
Gatto, Fancesco
core
Metabolic Engineering Optimizes Bioorthogonal Glycan Labeling in Living Cells
, 2021 Metabolic oligosaccharide engineering (MOE) has fundamentally contributed to our understanding of protein glycosylation. Efficient MOE reagents are activated into nucleotide-sugars by cellular biosynthetic machineries, introduced into glycoproteins and ...
Junwon, Choi +13 more
core +1 more source
Bioengineering, 2015 Metabolic engineering of various industrial microorganisms to produce chemicals, fuels, and drugs has raised interest since it is environmentally friendly, sustainable, and independent of nonrenewable resources.
Weihua Guo, Jiayuan Sheng, Xueyang Feng
doaj +1 more source
Metabolic Engineering of Yeast
Annual Review of BiophysicsMicrobial cell factories have been developed to produce various compounds in a sustainable and economically viable manner. The yeast Saccharomyces cerevisiae has been used as a platform cell factory in industrial biotechnology with numerous advantages, including ease of operation, rapid ...
Shuobo, Shi, Yu, Chen, Jens, Nielsen
openaire +2 more sources