Results 51 to 60 of about 632,889 (322)

Reconstruction of metabolic networks from high-throughput metabolite profiling data: in silico analysis of red blood cell metabolism

, 2007
We investigate the ability of algorithms developed for reverse engineering of transcriptional regulatory networks to reconstruct metabolic networks from high-throughput metabolite profiling data.
Barbagallo M., Butte A.J., C. J. UNKEFER, Frenkel E., G. S. ESCOLA, Garay R., I. NEMENMAN, Jacobasch G., Katz L., Kemp G., Kirk K., M. E. WALL, Mendes P., P. J. UNKEFER, Rose I., Steinhauser D., W. S. HLAVACEK, Walser M., Wang K.   +18 more
core   +1 more source

Freeform Bioprinting of Liver Encapsulated in Alginate Hydrogels Tissue Constructs for Pharmacokinetic Study [PDF]

, 2006
An in vitro model that can be realistically and inexpensively used to predict human response to various drug administration and toxic chemical exposure is needed.
Chang, R., Culbertson, C., Gonda, S., Holtorf, H., Starly, B., Sun, W.   +5 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Back to the future: Why we need enzymology to build a synthetic metabolism of the future

Beilstein Journal of Organic Chemistry, 2019
Biology is turning from an analytical into a synthetic discipline. This is especially apparent in the field of metabolic engineering, where the concept of synthetic metabolism has been recently developed.
Tobias J. Erb
doaj   +1 more source

13C-Metabolic Flux Analysis: An Accurate Approach to Demystify Microbial Metabolism for Biochemical Production

Bioengineering, 2015
Metabolic engineering of various industrial microorganisms to produce chemicals, fuels, and drugs has raised interest since it is environmentally friendly, sustainable, and independent of nonrenewable resources.
Weihua Guo, Jiayuan Sheng, Xueyang Feng
doaj   +1 more source

Lignin engineering in field-grown poplar trees affects the endosphere bacterial microbiome [PDF]

, 2016
Cinnamoyl-CoA reductase (CCR), an enzyme central to the lignin bio-synthetic pathway, represents a promising biotechnological target to reduce lignin levels and to improve the commercial viability of lignocellulosic biomass. However, silencing of the CCR
Beckers, Bram, Boerjan, Wout, Op De Beeck, Michiel, Van Acker, Rebecca, Van Montagu, Marc, Vangronsveld, Jaco, Weyens, Nele   +6 more
core   +2 more sources

Metabolic engineering of Bacillus subtilis with an Endopolygalacturonase gene Isolated from Pectobacterium. carotovorum ; a Plant Pathogenic Bacterial Strain [PDF]

, 2021
Nagina Rafique, Saiqa Bashir, Muhammad Zubair Khan, Imran Hayat, Willium-Orts, Dominic W. S. Wong   +5 more
openalex   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comprehensive evaluation of the capacities of microbial cell factories

Nature Communications
Systems metabolic engineering is facilitating the development of high-performing microbial cell factories for producing chemicals and materials. However, constructing an efficient microbial cell factory still requires exploring and selecting various host
Gi Bae Kim, Ha Rim Kim, Sang Yup Lee
doaj   +1 more source

The automated Galaxy-SynBioCAD pipeline for synthetic biology design and engineering

Nature Communications, 2022
Automated design and build processes can rapidly accelerate work in synthetic biology and metabolic engineering. Here the authors present Galaxy-SynBioCAD, a toolshed for synthetic biology, metabolic engineering, and industrial biotechnology that they ...
Joan Hérisson, Thomas Duigou, Melchior du Lac, Kenza Bazi-Kabbaj, Mahnaz Sabeti Azad, Gizem Buldum, Olivier Telle, Yorgo El Moubayed, Pablo Carbonell, Neil Swainston, Valentin Zulkower, Manish Kushwaha, Geoff S. Baldwin, Jean-Loup Faulon   +13 more
doaj   +1 more source