Results 71 to 80 of about 632,889 (322)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transcription Factor Engineering for High-Throughput Strain Evolution and Organic Acid Bioproduction: A Review

Frontiers in Bioengineering and Biotechnology, 2020
Metabolic regulation of gene expression for the microbial production of fine chemicals, such as organic acids, is an important research topic in post-genomic metabolic engineering.
Jia-Wei Li, Xiao-Yan Zhang, Hui Wu, Yun-Peng Bai   +3 more
doaj   +1 more source

Metabolic engineering of Escherichia coli into a versatile glycosylation platform : production of bio‐active quercetin glycosides [PDF]

, 2015
Background: Flavonoids are bio-active specialized plant metabolites which mainly occur as different glycosides. Due to the increasing market demand, various biotechnological approaches have been developed which use Escherichia coli as a microbial ...
De Bruyn, Frederik, De Mey, Marjan, Duchi, Dries, Maertens, Jo, Van Bellegem, Wouter, Van Brempt, Maarten   +5 more
core   +5 more sources

Genome scale engineering techniques for metabolic engineering [PDF]

Metabolic Engineering, 2015
Metabolic engineering has expanded from a focus on designs requiring a small number of genetic modifications to increasingly complex designs driven by advances in genome-scale engineering technologies. Metabolic engineering has been generally defined by the use of iterative cycles of rational genome modifications, strain analysis and characterization ...
Liu, Rongming, Bassalo, Marcelo C., Zeitoun, Ramsey I., Gill, Ryan T.   +3 more
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment

Journal of Integrative Bioinformatics, 2021
Microorganisms commonly produce many high-demand industrial products like fuels, food, vitamins, and other chemicals. Microbial strains are the strains of microorganisms, which can be optimized to improve their technological properties through metabolic ...
Man Mei Yen, Mohamad Mohd Saberi, Choon Yee Wen, Ismail Mohd Arfian   +3 more
doaj   +1 more source

Metabolic engineering of functional phytochemicals [PDF]

, 2013
Phytochemicals belonging to the group’s phenols, terpenes, betalains, organosulfides, indoles and protein inhibitors are important components in fruits, vegetables, legumes, whole grains and nuts that have health promoting benefits and a variety of ...
Abdul Hamid, Azizah, Mohammed, Abdulkarim Sabo, Radu, Son, Saari, Nazamid, Umar, Kabir Mustapha   +4 more
core  

Dynamic metabolic control: towards precision engineering of metabolism [PDF]

Journal of Industrial Microbiology and Biotechnology, 2018
Abstract Advances in metabolic engineering have led to the synthesis of a wide variety of valuable chemicals in microorganisms. The key to commercializing these processes is the improvement of titer, productivity, yield, and robustness.
Liu, D, Mannan, AA, Han, Y, Oyarzun, DA, Zhang, F   +4 more
openaire   +5 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Upon accounting for the impact of isoenzyme loss, gene deletion costs anticorrelate with their evolutionary rates [PDF]

, 2017
System-level metabolic network models enable the computation of growth and metabolic phenotypes from an organism’s genome. In particular, flux balance approaches have been used to estimate the contribution of individual metabolic genes to organismal ...
Jacobs, Christopher, Lambourne, Luke, Segre, Daniel, Xia, Yu   +3 more
core   +4 more sources