Results 81 to 90 of about 330,730 (300)

A new functional protein chip for in vitro metabolic engineering

, 2009
1
정규열
core  

Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering

Cells, 2013
Systems biology aims at achieving a system-level understanding of living organisms and applying this knowledge to various fields such as synthetic biology, metabolic engineering, and medicine. System-level understanding of living organisms can be derived
Bor-Sen Chen, Chia-Chou Wu
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Constraint-based metabolic control analysis for rational strain engineering

The advancements in genome editing techniques over the past years have rekindled interest in rational metabolic engineering strategies. While Metabolic Control Analysis (MCA) is a well-established method for quantifying the effects of metabolic ...
Ataman, Meriç, Hatzimanikatis, Vassily, Tsouka, Sofia, Miskovic, Ljubisa, Hameri, Tuure Eelis   +4 more
core   +1 more source

Microbial acetyl-CoA metabolism and metabolic engineering

, 2015
Recent concerns over the sustainability of petrochemical-based processes for production of desired chemicals have fueled research into alternative modes of production. Metabolic engineering of microbial cell factories such as Saccharomyces cerevisiae and
Chen, Yun,, Zhang, Yiming,, Krivoruchko, Anastasia,, Nielsen, Jens B, Krivoruchko, Anastasia, Siewers, Verena,, Chen, Yun, Zhang, Yiming, Siewers, Verena, Nielsen, Jens B,   +9 more
core   +1 more source

Combinatorial approaches for inverse metabolic engineering applications

Computational and Structural Biotechnology Journal, 2012
Traditional metabolic engineering analyzes biosynthetic and physiological pathways, identifies bottlenecks, and makes targeted genetic modifications with the ultimate goal of increasing the production of high-value products in living cells.
Georgios Skretas, Fragiskos N Kolisis
doaj   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Microbial metabolic engineering

Microbial Biotechnology, 2022
Lawrence P. Wackett
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Synthetic metabolic engineering of functional crops: Boosting nutrition and human health

Crop Journal
A growing global population and the increasing prevalence of diet-related health issues such as “hidden hunger”, obesity, hypertension, and diabetes necessitate a fundamental rethinking of crop design and breeding.
Nan Chai, Jie Xu, Ruixiang Zhang, Guangzhou Li, Jun Wen, Liying Su, Yang Xue, Tie Li, Jialin Liu, Dongchang Zeng, Jiantao Tan, Jiaqi Huang, Letian Chen, Yao-Guang Liu, Qinlong Zhu   +14 more
doaj   +1 more source