Results 31 to 40 of about 794,439 (319)

A Cysteine-Reloading Process Initiating the Biosynthesis of the Bicyclic Scaffold of Dithiolopyrrolones

Antibiotics, 2023
Dithiolopyrrolone antibiotics are well known for their outstanding biological activities, and their biosynthesis has been studied vigorously. However, the biosynthesis mechanism of the characteristic bicyclic scaffold is still unknown after years of ...
Yan Chen, Yanqin Tu, Tingyu Pan, Zixin Deng, Lian Duan   +4 more
doaj   +1 more source

Biosynthesis of Largimycins in Streptomyces argillaceus Involves Transient β‑Alkylation and Cryptic Halogenation Steps Unprecedented in the Leinamycin Family [PDF]

, 2022
Largimycins A1 and A2 are key members of a recently identified family of hybrid nonribosomal peptide polyketides belonging to the scarcely represented group of antitumor leinamycins.
Becerril García, Adriana, Martín, Jesús M., Salas Fernández, José Antonio, Reyes, Fernando, Pérez- Victoria Moreno de Barreda, Ignacio, Méndez Fernández, María Carmen   +5 more
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Biosynthesis of pyrrolopyrimidines [PDF]

Bioorganic Chemistry, 2012
Pyrrolopyrimidine containing compounds, also known as 7-deazapurines, are a collection of purine-based metabolites that have been isolated from a variety of biological sources and have diverse functions which range from secondary metabolism to RNA modification.
Reid M, McCarty, Vahe, Bandarian
openaire   +2 more sources

THE BIOSYNTHESIS OF SUCROSE

Journal of Biological Chemistry, 1955
The enzyme, which was named sucrose phosphorylase, has not been found in plant tissues (4), and thus the mechanism of sucrose synthesis remains obscure. Evidence obtained from tracer experiments led Buchanan et al. (5, 6) to assume that in plants sucrose phosphate is formed from UDPG’ and fructose-l-phosphate.
Cardini, Carlos E., Leloir, Luis Federico, Chiriboga J.   +2 more
openaire   +3 more sources

Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system

Nature Communications, 2021
Angustmycin A is a nucleoside antibiotic having anti-mycobacterial and cytokinin activities. Here, the authors report the whole pathway leading to angustmycin A biosynthesis in Streptomyces and achieve the heterologous production of angustmycin A in E ...
Le Yu, Wenting Zhou, Yixuan She, Hongmin Ma, You-Sheng Cai, Ming Jiang, Zixin Deng, Neil P. J. Price, Wenqing Chen   +8 more
doaj   +1 more source

The effects of estrogen on targeted cancer therapy drugs

Pharmacological Research, 2022
Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex hormone that not only promotes the development of female secondary sexual characteristics, but also supports many important physiological functions.
Ying Zhao, Xin Wang, Yi Liu, Hao-Yu Wang, Jin Xiang   +4 more
doaj   +1 more source

Diversity and Evolution of the Phenazine Biosynthesis Pathway [PDF]

, 2010
Phenazines are versatile secondary metabolites of bacterial origin that function in biological control of plant pathogens and contribute to the ecological fitness and pathogenicity of the producing strains.
Blankenfeldt, Wulf, Thomashow, L., Weller, David M, Lemanceau, P., Mazurier, Sylvie, S., Mazurier, S., Raaijmakers, J., Mavrodi, Dmitri V. Mavrodi, Heide, L., Peever, Tobin L., Raaijmakers, Jos M., Mavrodi, Dmitri V., Parejko, J., Thomashow, Linda S., Peever, T., Thomashow, L.S., Mazurier, Sylvie, Mavrodi, D., Mavrodi, Olga V., Mavrodi, D.V., Blankenfeldt, W., Weller, David M., Parejko, James A, Thomashow, Linda S, Mavrodi, O.V., Peever, Tobin L, Raaijmakers, J.M., Lemanceau, Philippe, Weller, D., Weller, D.M., Heide, Lutz, Mavrodi, O., Lemanceau, Philippe, P., Parejko, James A., Mavrodi, Olga V, Parejko, J.A., Peever, T.L., Raaijmakers, Jos M, Mavrodi, Dmitri V   +38 more
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The Current Status of Research on Gibberellin Biosynthesis [PDF]

, 2020
Gibberellins are produced by all vascular plants and several fungal and bacterial species that associate with plants as pathogens or symbionts. In the 60 years since the first experiments on the biosynthesis of gibberellic acid in the fungus Fusarium ...
Hedden, P.
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Effect of very low nicotine content cigarettes on smoking behavior in Chinese smokers with genotype-stratified nicotine metabolism rates

Frontiers in Psychiatry
BackgroundSmoking is a major public health issue worldwide, particularly in China where it is linked to serious diseases like lung cancer and cardiovascular disease. The genetic basis of nicotine metabolism, which varies significantly between Chinese and
Wanwan Ma, Wanwan Ma, Yaning Fu, Yaning Fu, Huan Chen, Huan Chen, Hongjuan Wang, Hongjuan Wang, Shulei Han, Shulei Han, Yushan Tian, Yushan Tian, Hongwei Hou, Hongwei Hou, Qingyuan Hu, Qingyuan Hu   +15 more
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The role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10 [PDF]

, 2014
Phosphopantetheinyl transferase (PPTase) enzymes fulfil essential roles in primary and secondary metabolism in prokaryotes, archaea and eukaryotes. PPTase enzymes catalyse the essential modification of the carrier protein domain of fatty acid synthases ...
Gerc, Amy J., Stanley-Wall, Nicola R.; id_orcid, Coulthurst, Sarah J.; id_orcid   +2 more
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