Results 41 to 50 of about 794,439 (319)

Oxytetracycline Biosynthesis [PDF]

Journal of Biological Chemistry, 2010
Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. OTC is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive ...
Lauren B, Pickens, Yi, Tang
openaire   +2 more sources

Puromycin A, B and C, cryptic nucleosides identified from Streptomyces alboniger NRRL B-1832 by PPtase-based activation

Synthetic and Systems Biotechnology, 2018
Natural product discovery is pivot for drug development, however, this endeavor is often challenged by the wide inactivation or silence of natural products biosynthetic pathways.
Xiaoli Yan, Benyin Zhang, Wenya Tian, Qi Dai, Xiaoqin Zheng, Ke Hu, Xinxin Liu, Zixin Deng, Xudong Qu   +8 more
doaj   +1 more source

Diversity and functional analysis of LuxR-type transcriptional regulators of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens

, 2009
Cyclic lipopeptides (CLPs) are produced by many Pseudomonas species and have several biological functions, including a role in surface motility, biofilm formation, virulence, and antimicrobial activity.
Bruijn, I., de, Raaijmakers, J.M., de Bruijn, I.   +2 more
core   +1 more source

Environmental degradation of plastics containing pro-oxidant additives and their toxicological impact in desert ecosystems

Case Studies in Chemical and Environmental Engineering
The accumulation of single-use plastic materials poses significant environmental and waste management challenges. Pro-oxidant additive-containing (PAC) plastics have been introduced in many regions to mitigate these impacts.
Diya Alsafadi, Mohammad Abu Nuwar, Amani Abdelhadi, Tasnim Alqaruoti, Lama Siwwan, Ahmad Al Amaireh   +5 more
doaj   +1 more source

A new type of DNA phosphorothioation-based antiviral system in archaea

Nature Communications, 2019
The prokaryote defence system Dnd relies on phosphorothioation (PT) of DNA backbone to distinguish between self and non-self DNA. Here, Xiong et al. describe a previously uncharacterized PT-based antiviral system that is independent of the canonical Dnd ...
Lei Xiong, Siyi Liu, Si Chen, Yao Xiao, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen   +12 more
doaj   +1 more source

Thiohistidine Biosynthesis

CHIMIA, 2013
Ergothioneine and ovothiol A are sulfur-containing histidine derivatives produced by microorganisms including Mycobacterium tuberculosis, Trypanosoma cruzi or Erwinia amylovora and may also play important roles in human physiology. Based on our recent identification of thiohistidine biosynthetic enzymes from Mycobacterium smegmatis and ...
openaire   +5 more sources

Natural Products from Mangrove Actinomycetes

Marine Drugs, 2014
Mangroves are woody plants located in tropical and subtropical intertidal coastal regions. The mangrove ecosystem is becoming a hot spot for natural product discovery and bioactivity survey.
Dong-Bo Xu, Wan-Wan Ye, Ying Han, Zi-Xin Deng, Kui Hong   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Regulation of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens by the ClpP protease

, 2009
Cyclic lipopeptides produced by Pseudomonas species exhibit potent surfactant and broad-spectrum antibiotic properties. Their biosynthesis is governed by large multimodular nonribosomal peptide synthetases, but little is known about the genetic ...
Bruijn, I., de, Raaijmakers, J.M., de Bruijn, I.   +2 more
core   +1 more source

The biosynthesis of porphyrins

Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie, 1948
This article is intended as a summary of some of the work which has been done, over the past ten years, on the biosynthesis of porphyrins. The treatment accorded to this subject should not be considered to be that of an exhaustive review article. It will consider only those papers which, in the author’s opinion, are most pertinent to the particular ...
openaire   +3 more sources