Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses [PDF]
BiomoleculesProtein S-palmitoylation is a pivotal yet poorly integrated research field in dermatology. This reversible post-translational lipid modification primarily occurs on cysteine residues and is principally catalyzed by zinc finger and Asp-His-His-Cys DHHC ...
Yanhai Feng +9 more
doaj +2 more sources
Molecular Therapy - Nucleic Acids, 2022 High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune ...
Feng Tang, Dong-Hu Yu, Zhi-Yong Pan
exaly +3 more sources
A palmitoyl transferase chemical genetic system to map ZDHHC-specific S -acylation [PDF]
, 2023 Abstract The 23 human ZDHHC S -acyltransferases catalyze long-chain S -acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease.
Ocasio CA +13 more
europepmc +4 more sources
Recent advances in S-palmitoylation and its emerging roles in human diseases [PDF]
Journal of Hematology & OncologyS-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions.
Juanjuan Shang +2 more
doaj +2 more sources
ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma
BMC Cancer, 2023 Background Glioma is the most common and aggressive tumor in the adult brain. Recent studies have indicated that Zinc finger DHHC-type palmitoyltransferases (ZDHHCs) play vital roles in regulating the progression of glioma.
Ze-Fen Wang, Li Zhiqiang, Wang Ze-Fen
exaly +2 more sources
ZDHHC9 and spermine metabolism: a palmitoylation-driven pathway to prostate carcinogenesis [PDF]
Journal of Translational MedicineBackground Spermine is a natural metabolite that has been shown to hinder the progression of prostate cancer. Protein palmitoylation, a recently identified post-translational lipid modification, is catalyzed by a family of 23 enzymes known as zinc finger
Chunli Chen +13 more
doaj +2 more sources
Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma
Frontiers in Cell and Developmental Biology, 2021 S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane.
Yitong Zhang +2 more
exaly +3 more sources
Accessory proteins of the zDHHC family of S-acylation enzymes [PDF]
Journal of Cell Science, 2020 ABSTRACT Almost two decades have passed since seminal work in Saccharomyces cerevisiae identified zinc finger DHHC domain-containing (zDHHC) enzymes as S-acyltransferases. These enzymes are ubiquitous in the eukarya domain, with 23 distinct zDHHC-encoding genes in the human genome.
Christine Salaün +4 more
openalex +6 more sources
RETRACTED ARTICLE: Palmitoyl transferases act as novel drug targets for pancreatic cancer
Journal of Translational Medicine, 2023 Background Pancreatic adenocarcinoma (PAAD) is one of the most leading causes of cancer-related death across the world with the limited efficiency and response rate of immunotherapy.
Zhiqing Lin +3 more
doaj +2 more sources
ZDHHC2-Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation. [PDF]
Adv Sci (Weinh)Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shao S +10 more
europepmc +2 more sources