Results 21 to 30 of about 481 (138)

Role of S-palmitoylation in digestive system diseases [PDF]

Cell Death Discovery
Digestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide.
Hanqing Li, Qiuxiang Yuan, Shuangshuang Wang, Tao Yu, Xingsi Qi   +4 more
doaj   +2 more sources

ZDHHC9 and spermine metabolism: a palmitoylation-driven pathway to prostate carcinogenesis [PDF]

Journal of Translational Medicine
Background Spermine is a natural metabolite that has been shown to hinder the progression of prostate cancer. Protein palmitoylation, a recently identified post-translational lipid modification, is catalyzed by a family of 23 enzymes known as zinc finger
Chunli Chen, Yiqun Zhang, Gaofa Wang, Yang Liu, Bin Ye, Shengqiang Zhou, Kelong Wang, Haojie Zheng, Xiaoxia Dong, Chao Luo, Junshuo Zhou, Kangkang Zeng, Caiyun Fang, Li Shen   +13 more
doaj   +2 more sources

Research progress on S-palmitoylation modification mediated by the ZDHHC family in glioblastoma. [PDF]

Front Cell Dev Biol
S-Palmitoylation has been widely noticed and studied in a variety of diseases. Increasing evidence suggests that S-palmitoylation modification also plays a key role in Glioblastoma (GBM). The zDHHC family, as an important member of S-palmitoyltransferases, has received extensive attention for its function and mechanism in GBM which is one of the most ...
Tang B, Kang W, Dong Q, Qin Z, Duan L, Zhao X, Yuan G, Pan Y.   +7 more
europepmc   +4 more sources

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer [PDF]

Advanced Science, Volume 13, Issue 41, 22 July 2026.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +2 more sources

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation [PDF]

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +2 more sources

Comprehensive analysis of key palmitoylation-modifying enzymes in clear cell renal cell carcinoma: implications for prognosis and therapy

Cancer Cell International
Background Palmitoylation, a key post-translational modification, plays a crucial role in tumor progression, yet its landscape in clear cell renal cell carcinoma (ccRCC) remains poorly characterized.
Guangzhen Wu, Xiangyu Che
exaly   +2 more sources

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation

Nature Biotechnology
The 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S-acyltransferases catalyze long-chain S-acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease. Here
James Macrae, Julian Downward, Cory Antonio Ocasio   +2 more
exaly   +2 more sources

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation [PDF]

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +2 more sources

Defective anterograde protein-trafficking contributes to endoplasmic reticulum-stress in a CLN1 disease model

Neurobiology of Disease
Lysosomal storage disorders (LSDs) represent 70 inherited metabolic diseases, in most of which neurodegeneration is a devastating manifestation. The CLN1 disease is a fatal neurodegenerative LSD, caused by inactivating mutations in the CLN1 gene encoding
Nisha Plavelil, Abhilash P. Appu, K.C. Gopal, Avisek Mondal, Neil Perkins, Anil B. Mukherjee   +5 more
doaj   +2 more sources

Accessory proteins of the zDHHC family of S-acylation enzymes [PDF]

Journal of Cell Science, 2020
ABSTRACT Almost two decades have passed since seminal work in Saccharomyces cerevisiae identified zinc finger DHHC domain-containing (zDHHC) enzymes as S-acyltransferases. These enzymes are ubiquitous in the eukarya domain, with 23 distinct zDHHC-encoding genes in the human genome.
Christine Salaun, Carolina Locatelli, Filip Zmuda, Juan Cabrera González, Luke H. Chamberlain   +4 more
openaire   +5 more sources