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The zDHHC family of S-acyltransferases [PDF]
Biochemical Society Transactions, 2015 The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of ...
Lemonidis, Kimon +7 more
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Substrate selectivity in the zDHHC family of S-acyltransferases [PDF]
Biochemical Society Transactions, 2017 S-acylation is a reversible lipid modification occurring on cysteine residues mediated by a family of membrane-bound ‘zDHHC’ enzymes. S-acylation predominantly results in anchoring of soluble proteins to membrane compartments or in the trafficking of membrane proteins to different compartments.
Lemonidis, Kimon +5 more
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Regulatory effects of post-translational modifications on zDHHC S-acyltransferases [PDF]
Journal of Biological Chemistry, 2020 The human zDHHC S-acyltransferase family comprises 23 enzymes that mediate the S-acylation of a multitude of cellular proteins, including channels, receptors, transporters, signaling molecules, scaffolds, and chaperones. This reversible post-transitional modification (PTM) involves the attachment of a fatty acyl chain, usually derived from palmitoyl ...
Filip Zmuda, Luke H. Chamberlain
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Cytoplasmic tail determines the membrane trafficking and localization of SARS-CoV-2 spike protein
Frontiers in Molecular Biosciences, 2022 The spike (S) glycoprotein of SARS-CoV-2 mediates viral entry through associating with ACE2 on host cells. Intracellular trafficking and palmitoylation of S protein are required for its function.
Qinlin Li +7 more
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Heliyon, 2023 Aims: The osteogenesis of human bone marrow mesenchymal stem cells (hBMSCs) plays a critical role in fracture healing. Osteogenic differentiation is regulated by a variety of post-translational modifications, but the function of protein palmitoylation in
Zhiwei Li +6 more
doaj +1 more source
In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases
Open Biology, 2022 Protein S-acylation, more commonly known as protein palmitoylation, is a biological process defined by the covalent attachment of long chain fatty acids onto cysteine residues of a protein, effectively altering the local hydrophobicity and influencing its stability, localization and overall function.
R. Elliot Murphy, Anirban Banerjee
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Identification of a novel sequence motif recognised by the ankyrin-repeat domain of zDHHC17/13 S-acyl-transferases [PDF]
, 2015 S-acylation is a major post-translational modification affecting several cellular processes and being particularly important for neuronal functions. This modification is catalysed by a family of transmembrane S-acyl-transferases that contain a conserved ...
Chamberlain, Luke H. +2 more
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Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma
Frontiers in Cell and Developmental Biology, 2021 S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane.
Yitong Zhang +5 more
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Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase [PDF]
Communications Biology, 2020 AbstractAlthough palmitoylation regulates numerous cellular processes, as yet efforts to manipulate this post-translational modification for therapeutic gain have proved unsuccessful. The Na-pump accessory sub-unit phospholemman (PLM) is palmitoylated by zDHHC5.
Fiona Plain +6 more
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High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases
, 2021 As enzymes that mediate the attachment of long-chain fatty acids to cysteine residues, ZDHHC proteins have been reported to be promising therapeutic targets for treating cancer and autoimmune diseases. Yet, due to the lack of potent selective inhibitors,
Yinong Liu (1396411) +17 more
core +1 more source