Results 51 to 60 of about 481 (138)

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, Volume 13, Issue 42, 28 July 2026.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation

PLOS ONE
Reversible S-palmitoylation of protein cysteines, catalysed by a family of integral membrane zDHHC-motif containing palmitoyl acyl transferases (zDHHC-PATs), controls the localisation, activity, and interactions of numerous integral and peripheral membrane proteins.
Mingjie Bai, Emily Gallen, Sarah Memarzadeh, Jacqueline Howie, Xing Gao, Chien-Wen S. Kuo, Elaine Brown, Simon Swingler, Sam J. Wilson, Michael J. Shattock, David J. France, William Fuller   +11 more
openaire   +3 more sources

Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases

Frontiers in Immunology
Protein palmitoylation is a reversible lipid modification in which palmitoyl esters are covalently attached to cysteine residues of proteins. It controls various cellular physiological processes and alters protein stability, conformation, localization ...
Rong Chen, Rong Chen, Xiaohua Tang, Ying Wang, Bo Wang, Fei Mao, Fei Mao   +6 more
doaj   +1 more source

Data_Sheet_1_Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma.docx

, 2021
S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane.
Fenglan Li (307350), Xiqing Liu (9639835), Kexin Fu (10047327), Yitong Zhang (8484414), Hui Li (32376), I-Chia Lien (10494831)   +5 more
core   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

S-acylation and neuroinflammation: the therapeutic potential of zDHHC and deacylase modulation

European Journal of Medicinal Chemistry
Neuroinflammation is a hallmark of many neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's disease, multiple sclerosis, and infantile neuronal ceroid lipofuscinosis. Dynamic protein S-acylation, a reversible lipid post-translational modification, is an important regulator in these processes.
Tiago A. Duarte, Choa P. Ng, Jorge A.R. Salvador, Ludovico Pipito, Jennifer Greaves, Vânia M. Moreira   +5 more
openaire   +2 more sources

Table_1_Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma.XLSX

, 2021
S-palmitoylation, catalyzed by a family of 23 zinc finger Asp-His-His-Cys (DHHC) domain-containing (ZDHHC) protein acyltransferases localized on the cell membrane.
Fenglan Li (307350), Xiqing Liu (9639835), Kexin Fu (10047327), Yitong Zhang (8484414), Hui Li (32376), I-Chia Lien (10494831)   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A palmitoyl transferase chemical genetic system to map ZDHHC-specific S -acylation

, 2023
Abstract The 23 human ZDHHC S -acyltransferases catalyze long-chain S -acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease.
Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Susana A. Palma-Duran, James I. MacRae, Goran Tomic, Lotte Carr, Julian Downward, Ulrike S. Eggert, Edward W. Tate   +13 more
openaire   +2 more sources

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G., Kamini Shivhare, Piyush Kumar Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rahul Shukla   +5 more
wiley   +1 more source