Results 71 to 80 of about 473 (132)

Aberrant Protein S‐Palmitoylation: A Novel Therapeutic Target in Alzheimer's Disease

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Protein post‐translational modifications are critical regulators of synaptic function, and their disruption is implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Among these modifications, S‐palmitoylation, catalyzed by zinc finger DHHC domain‐containing (zDHHC) S‐acyltransferases, has ...
Claudio Grassi, Francesca Natale, Matteo Spinelli, Marco Rinaudo, Ida Nifo Sarrapochiello, Giuseppe Aceto, Daniela Puzzo, Salvatore Fusco   +7 more
wiley   +1 more source

Blueberries Reduce Palm Oil‐Induced Metabolic Endotoxemia in an In Vitro Human Intestinal‐Immune Cell Model

Molecular Nutrition &Food Research, Volume 69, Issue 24, December 2025.
Digested palm oil and LPS treatment on intestinal Caco‐2 cells results in palm oil‐induced LPS translocation across the intestinal cell monolayer and nuclear factor kappa B (NF‐κB) activation of basolateral macrophages. Interestingly, digested whole berries reduce the palm oil + LPS‐mediated NF‐κB activation in macrophages.
Aina Casademont‐Roca, Monic M. M. Tomassen, Sander Kersten, Wilma T. Steegenga, Guido J. Hooiveld, Jurriaan J. Mes   +5 more
wiley   +1 more source

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty Acids

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin, Yulong Hong, Yongqi Zhao, Wensheng Shi, Ruilin Liu, Xinyu You, Chong Yang, Yu Zhang   +7 more
wiley   +1 more source

Novel chemical genetic tools for the proteomic profiling of S-acylation by ZDHHC enzymes

, 2023
Post-translational modifications (PTM) represent the largest source of proteome diversity, regulating the function and fate of almost every eukaryotic protein. One of these is S-acylation, which refers to the post-translational covalent attachment of long-chain fatty acids onto thiol groups in surface-exposed cysteine residues.
openaire   +2 more sources

Epilepsy, cognitive deficits and neuroanatomy in males with ZDHHC9 mutations [PDF]

, 2015
Kate Baker, Duncan E. Astle, Gaia Scerif, Jessica Barnes, JENNIE SMITH, Georgina Moffat, Jonathan H. Gillard, Torsten Baldeweg, F. Lucy Raymond   +8 more
openalex   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications. [PDF]

J Cell Biol, 2023
Anwar MU, van der Goot FG.
europepmc   +1 more source

The impact of post-translational modifications and subcellular localization on NLRP3 inflammasome activation: A systematic review. [PDF]

Cell Commun Signal
Zhang S, Usman M, Wu Q, Gao Y, Fu L, Chu M, Jia C.   +6 more
europepmc   +1 more source

ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition. [PDF]

Cancer Med, 2023
Dai H, Wu R, Zhang J, Dou R, Xu M, Wang J, Wang J, Su F, Zhang T.   +8 more
europepmc   +1 more source