Results 71 to 80 of about 481 (138)
Aberrant Protein S‐Palmitoylation: A Novel Therapeutic Target in Alzheimer's Disease
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background Protein post‐translational modifications are critical regulators of synaptic function, and their disruption is implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Among these modifications, S‐palmitoylation, catalyzed by zinc finger DHHC domain‐containing (zDHHC) S‐acyltransferases, has ...
Claudio Grassi +7 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 69, Issue 24, December 2025.Digested palm oil and LPS treatment on intestinal Caco‐2 cells results in palm oil‐induced LPS translocation across the intestinal cell monolayer and nuclear factor kappa B (NF‐κB) activation of basolateral macrophages. Interestingly, digested whole berries reduce the palm oil + LPS‐mediated NF‐κB activation in macrophages.
Aina Casademont‐Roca +5 more
wiley +1 more source
Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
Dynamic regulation of palmitoyltransferases by synaptic activity
, 2020 The formation and remodelling of synaptic contacts require the precise distribution and trafficking of proteins to specialized compartments. This dynamic trafficking of synaptic proteins is partly controlled by palmitoylation, which is the most common ...
Abazari, Danya
core +1 more source
Palmitoylation by ZDHHC family members regulate B-cell lymphoma growth
International Journal of Biological MacromoleculesThe ZDHHC palmitoyl transferase family consists of 24 members, of which several have been linked to the development of cancer. We previously showed that inhibition of ZDHHC11 decreased growth of several B-cell lymphoma subtypes. In this study, we evaluated the effect of protein palmitoylation on the proteome in general and investigated expression and ...
Liu, Yichen +14 more
openaire +2 more sources
Plenary Abstracts Session & Oral Presentations
HemaSphere, Volume 10, Issue S1, June 2026.
wiley +1 more source
THE ROLE OF ZDHHC7 AND S-PALMITOYLATION IN ANTIVIRAL INNATE IMMUNITY
135 pagesProtein lipidation including cysteine palmitoylation (S-palmitoylation) significantly enhances protein hydrophobicity and membrane association. S-palmitoylation, catalyzed by the ZDHHC (zinc finger Asp-His-His-Cys) family of enzymes, occurs on a
Liu, Yinong
core +1 more source
zDHHC21 loss of function activates lung fibroblasts by regulating PTEN palmitoylation. [PDF]
Am J Respir Cell Mol BiolShayahati B +3 more
europepmc +1 more source
<i>S</i>-Palmitoylation in Health and Disease. [PDF]
BiochemistryWong W, Hu M, Isaacson RL.
europepmc +1 more source
The Activation of ARF1 Is Dynamically Regulated by its Palmitoylation. [PDF]
Mol Cell ProteomicsZhu J +7 more
europepmc +1 more source